Multiple air pollutant exposure and lung cancer in Tehran, Iran

Abstract Lung cancer is the most rapidly increasing malignancy worldwide with an estimated 2.1 million cancer cases in the latest, 2018 World Health Organization (WHO) report. The objective of this study was to investigate the association of air pollution and lung cancer, in Tehran, Iran. Residentia...

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Autores principales:	Zahra Khorrami, Mohsen Pourkhosravani, Maysam Rezapour, Koorosh Etemad, Seyed Mahmood Taghavi-Shahri, Nino Künzli, Heresh Amini, Narges Khanjani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d552bad4f9574d21adeaacba715217cc
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spelling	oai:doaj.org-article:d552bad4f9574d21adeaacba715217cc2021-12-02T13:41:43ZMultiple air pollutant exposure and lung cancer in Tehran, Iran10.1038/s41598-021-88643-42045-2322https://doaj.org/article/d552bad4f9574d21adeaacba715217cc2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88643-4https://doaj.org/toc/2045-2322Abstract Lung cancer is the most rapidly increasing malignancy worldwide with an estimated 2.1 million cancer cases in the latest, 2018 World Health Organization (WHO) report. The objective of this study was to investigate the association of air pollution and lung cancer, in Tehran, Iran. Residential area information of the latest registered lung cancer cases that were diagnosed between 2014 and 2016 (N = 1,850) were inquired from the population-based cancer registry of Tehran. Long-term average exposure to PM10, SO2, NO, NO2, NOX, benzene, toluene, ethylbenzene, m-xylene, p-xylene, o-xylene (BTEX), and BTEX in 22 districts of Tehran were estimated using land use regression models. Latent profile analysis (LPA) was used to generate multi-pollutant exposure profiles. Negative binomial regression analysis was used to examine the association between air pollutants and lung cancer incidence. The districts with higher concentrations for all pollutants were mostly in downtown and around the railway station. Districts with a higher concentration for NOx (IRR = 1.05, for each 10 unit increase in air pollutant), benzene (IRR = 3.86), toluene (IRR = 1.50), ethylbenzene (IRR = 5.16), p-xylene (IRR = 9.41), o-xylene (IRR = 7.93), m-xylene (IRR = 2.63) and TBTEX (IRR = 1.21) were significantly associated with higher lung cancer incidence. Districts with a higher multiple air-pollution profile were also associated with more lung cancer incidence (IRR = 1.01). Our study shows a positive association between air pollution and lung cancer incidence. This association was stronger for, respectively, p-xylene, o-xylene, ethylbenzene, benzene, m-xylene and toluene.Zahra KhorramiMohsen PourkhosravaniMaysam RezapourKoorosh EtemadSeyed Mahmood Taghavi-ShahriNino KünzliHeresh AminiNarges KhanjaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zahra Khorrami Mohsen Pourkhosravani Maysam Rezapour Koorosh Etemad Seyed Mahmood Taghavi-Shahri Nino Künzli Heresh Amini Narges Khanjani Multiple air pollutant exposure and lung cancer in Tehran, Iran
description	Abstract Lung cancer is the most rapidly increasing malignancy worldwide with an estimated 2.1 million cancer cases in the latest, 2018 World Health Organization (WHO) report. The objective of this study was to investigate the association of air pollution and lung cancer, in Tehran, Iran. Residential area information of the latest registered lung cancer cases that were diagnosed between 2014 and 2016 (N = 1,850) were inquired from the population-based cancer registry of Tehran. Long-term average exposure to PM10, SO2, NO, NO2, NOX, benzene, toluene, ethylbenzene, m-xylene, p-xylene, o-xylene (BTEX), and BTEX in 22 districts of Tehran were estimated using land use regression models. Latent profile analysis (LPA) was used to generate multi-pollutant exposure profiles. Negative binomial regression analysis was used to examine the association between air pollutants and lung cancer incidence. The districts with higher concentrations for all pollutants were mostly in downtown and around the railway station. Districts with a higher concentration for NOx (IRR = 1.05, for each 10 unit increase in air pollutant), benzene (IRR = 3.86), toluene (IRR = 1.50), ethylbenzene (IRR = 5.16), p-xylene (IRR = 9.41), o-xylene (IRR = 7.93), m-xylene (IRR = 2.63) and TBTEX (IRR = 1.21) were significantly associated with higher lung cancer incidence. Districts with a higher multiple air-pollution profile were also associated with more lung cancer incidence (IRR = 1.01). Our study shows a positive association between air pollution and lung cancer incidence. This association was stronger for, respectively, p-xylene, o-xylene, ethylbenzene, benzene, m-xylene and toluene.
format	article
author	Zahra Khorrami Mohsen Pourkhosravani Maysam Rezapour Koorosh Etemad Seyed Mahmood Taghavi-Shahri Nino Künzli Heresh Amini Narges Khanjani
author_facet	Zahra Khorrami Mohsen Pourkhosravani Maysam Rezapour Koorosh Etemad Seyed Mahmood Taghavi-Shahri Nino Künzli Heresh Amini Narges Khanjani
author_sort	Zahra Khorrami
title	Multiple air pollutant exposure and lung cancer in Tehran, Iran
title_short	Multiple air pollutant exposure and lung cancer in Tehran, Iran
title_full	Multiple air pollutant exposure and lung cancer in Tehran, Iran
title_fullStr	Multiple air pollutant exposure and lung cancer in Tehran, Iran
title_full_unstemmed	Multiple air pollutant exposure and lung cancer in Tehran, Iran
title_sort	multiple air pollutant exposure and lung cancer in tehran, iran
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d552bad4f9574d21adeaacba715217cc
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Multiple air pollutant exposure and lung cancer in Tehran, Iran

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