Model-based understanding of single-cell CRISPR screening

Single-cell CRISPR screening combines pooled CRISPR screening with scRNA-seq analysis to expand the resolution power of genetic screening. Here, the authors develop MUSIC, a computational pipeline for analyzing single-cell CRISPR screening data.

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Autores principales:	Bin Duan, Chi Zhou, Chengyu Zhu, Yifei Yu, Gaoyang Li, Shihua Zhang, Chao Zhang, Xiangyun Ye, Hanhui Ma, Shen Qu, Zhiyuan Zhang, Ping Wang, Shuyang Sun, Qi Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d55325cc875f45339a237406f0ff60cf
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spelling	oai:doaj.org-article:d55325cc875f45339a237406f0ff60cf2021-12-02T15:36:21ZModel-based understanding of single-cell CRISPR screening10.1038/s41467-019-10216-x2041-1723https://doaj.org/article/d55325cc875f45339a237406f0ff60cf2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10216-xhttps://doaj.org/toc/2041-1723Single-cell CRISPR screening combines pooled CRISPR screening with scRNA-seq analysis to expand the resolution power of genetic screening. Here, the authors develop MUSIC, a computational pipeline for analyzing single-cell CRISPR screening data.Bin DuanChi ZhouChengyu ZhuYifei YuGaoyang LiShihua ZhangChao ZhangXiangyun YeHanhui MaShen QuZhiyuan ZhangPing WangShuyang SunQi LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bin Duan Chi Zhou Chengyu Zhu Yifei Yu Gaoyang Li Shihua Zhang Chao Zhang Xiangyun Ye Hanhui Ma Shen Qu Zhiyuan Zhang Ping Wang Shuyang Sun Qi Liu Model-based understanding of single-cell CRISPR screening
description	Single-cell CRISPR screening combines pooled CRISPR screening with scRNA-seq analysis to expand the resolution power of genetic screening. Here, the authors develop MUSIC, a computational pipeline for analyzing single-cell CRISPR screening data.
format	article
author	Bin Duan Chi Zhou Chengyu Zhu Yifei Yu Gaoyang Li Shihua Zhang Chao Zhang Xiangyun Ye Hanhui Ma Shen Qu Zhiyuan Zhang Ping Wang Shuyang Sun Qi Liu
author_facet	Bin Duan Chi Zhou Chengyu Zhu Yifei Yu Gaoyang Li Shihua Zhang Chao Zhang Xiangyun Ye Hanhui Ma Shen Qu Zhiyuan Zhang Ping Wang Shuyang Sun Qi Liu
author_sort	Bin Duan
title	Model-based understanding of single-cell CRISPR screening
title_short	Model-based understanding of single-cell CRISPR screening
title_full	Model-based understanding of single-cell CRISPR screening
title_fullStr	Model-based understanding of single-cell CRISPR screening
title_full_unstemmed	Model-based understanding of single-cell CRISPR screening
title_sort	model-based understanding of single-cell crispr screening
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d55325cc875f45339a237406f0ff60cf
work_keys_str_mv	AT binduan modelbasedunderstandingofsinglecellcrisprscreening AT chizhou modelbasedunderstandingofsinglecellcrisprscreening AT chengyuzhu modelbasedunderstandingofsinglecellcrisprscreening AT yifeiyu modelbasedunderstandingofsinglecellcrisprscreening AT gaoyangli modelbasedunderstandingofsinglecellcrisprscreening AT shihuazhang modelbasedunderstandingofsinglecellcrisprscreening AT chaozhang modelbasedunderstandingofsinglecellcrisprscreening AT xiangyunye modelbasedunderstandingofsinglecellcrisprscreening AT hanhuima modelbasedunderstandingofsinglecellcrisprscreening AT shenqu modelbasedunderstandingofsinglecellcrisprscreening AT zhiyuanzhang modelbasedunderstandingofsinglecellcrisprscreening AT pingwang modelbasedunderstandingofsinglecellcrisprscreening AT shuyangsun modelbasedunderstandingofsinglecellcrisprscreening AT qiliu modelbasedunderstandingofsinglecellcrisprscreening
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Model-based understanding of single-cell CRISPR screening

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