Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus

Asmaa Abd El Wakeel Elsehmawy,1 Safinaz Ebrahim El-Toukhy,2 Nora Mohamed Ahmed Seliem,3 Rehab Selim Moustafa,4 Doaa Sayed Mohammed5 1Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 2Department of Medical Biochemistry, National Research Center, Cairo, Egypt; 3Biochem...

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Autores principales:	Elsehmawy AAEW, El-Toukhy SE, Seliem NMA, Moustafa RS, Mohammed DS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Apelin Chemerin Children Diabetes Mellitus. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d556008a39584b7a9d7c6103399e85c4
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spelling	oai:doaj.org-article:d556008a39584b7a9d7c6103399e85c42021-12-02T11:55:35ZApelin and chemerin as promising adipokines in children with type 1 diabetes mellitus1178-7007https://doaj.org/article/d556008a39584b7a9d7c6103399e85c42019-03-01T00:00:00Zhttps://www.dovepress.com/apelin-and-chemerin-as-promising-adipokines-in-children-with-type-1-di-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Asmaa Abd El Wakeel Elsehmawy,1 Safinaz Ebrahim El-Toukhy,2 Nora Mohamed Ahmed Seliem,3 Rehab Selim Moustafa,4 Doaa Sayed Mohammed5 1Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 2Department of Medical Biochemistry, National Research Center, Cairo, Egypt; 3Biochemistry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 4Child Health Department, National Research Center, Cairo, Egypt; 5Endocrine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt Background: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children that may be due to micro or macrovascular complications. Diabetic renal disease or nephropathy is a common complication of DM, clinically silent and the only detectable abnormality due to the presence of microalbuminuria.Subjects and methods: This study was a case–control study. Participants were classified into two groups. The first group included 40 children with T1DM and the second group included 30 matched healthy controls. Serum apelin (APLN), chemerin, cholesterol, and triglycerides (TG) levels were measured for each case. Also, albumin/creatinine ratio was analyzed in random urine sample.Results: Comparison between T1DM patients and controls revealed that serum apelin, chemerin, cholesterol, TG levels, and albuminuria were significantly increased in cases compared to their controls. Significant positive correlations were found between HbA1c% and albuminuria for APLN and chemerin in the diabetic group. Whereas significant negative correlations were found between apelin and glomerular filtration rate (GFR). Conclusion: Increased levels of serum apelin and chemerin in T1DM patients may be considered as promising adipokines for the development of diabetic complication. Keywords: apelin, chemerin, children, diabetes mellitus  Elsehmawy AAEWEl-Toukhy SESeliem NMAMoustafa RSMohammed DSDove Medical PressarticleApelinChemerinChildrenDiabetes Mellitus.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 383-389 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Apelin Chemerin Children Diabetes Mellitus. Specialties of internal medicine RC581-951
spellingShingle	Apelin Chemerin Children Diabetes Mellitus. Specialties of internal medicine RC581-951 Elsehmawy AAEW El-Toukhy SE Seliem NMA Moustafa RS Mohammed DS Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus
description	Asmaa Abd El Wakeel Elsehmawy,1 Safinaz Ebrahim El-Toukhy,2 Nora Mohamed Ahmed Seliem,3 Rehab Selim Moustafa,4 Doaa Sayed Mohammed5 1Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 2Department of Medical Biochemistry, National Research Center, Cairo, Egypt; 3Biochemistry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 4Child Health Department, National Research Center, Cairo, Egypt; 5Endocrine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt Background: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children that may be due to micro or macrovascular complications. Diabetic renal disease or nephropathy is a common complication of DM, clinically silent and the only detectable abnormality due to the presence of microalbuminuria.Subjects and methods: This study was a case–control study. Participants were classified into two groups. The first group included 40 children with T1DM and the second group included 30 matched healthy controls. Serum apelin (APLN), chemerin, cholesterol, and triglycerides (TG) levels were measured for each case. Also, albumin/creatinine ratio was analyzed in random urine sample.Results: Comparison between T1DM patients and controls revealed that serum apelin, chemerin, cholesterol, TG levels, and albuminuria were significantly increased in cases compared to their controls. Significant positive correlations were found between HbA1c% and albuminuria for APLN and chemerin in the diabetic group. Whereas significant negative correlations were found between apelin and glomerular filtration rate (GFR). Conclusion: Increased levels of serum apelin and chemerin in T1DM patients may be considered as promising adipokines for the development of diabetic complication. Keywords: apelin, chemerin, children, diabetes mellitus
format	article
author	Elsehmawy AAEW El-Toukhy SE Seliem NMA Moustafa RS Mohammed DS
author_facet	Elsehmawy AAEW El-Toukhy SE Seliem NMA Moustafa RS Mohammed DS
author_sort	Elsehmawy AAEW
title	Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus
title_short	Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus
title_full	Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus
title_fullStr	Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus
title_full_unstemmed	Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus
title_sort	apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/d556008a39584b7a9d7c6103399e85c4
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Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus

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