Both IRBIT and long-IRBIT bind to and coordinately regulate Cl−/HCO3 − exchanger AE2 activity through modulating the lysosomal degradation of AE2

Both IRBIT and long-IRBIT bind to and coordinately regulate Cl−/HCO3 − exchanger AE2 activity through modulating the lysosomal degradation of AE2

Abstract Anion exchanger 2 (AE2) plays crucial roles in regulating cell volume homeostasis and cell migration. We found that both IRBIT and Long-IRBIT (L-IRBIT) interact with anion exchanger 2 (AE2). The interaction occurred between the conserved AHCY-homologous domain of IRBIT/L-IRBIT and the N-ter...

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Main Authors: Ryo Itoh, Naoya Hatano, Momoko Murakami, Kosuke Mitsumori, Satoko Kawasaki, Tomoka Wakagi, Yoshino Kanzaki, Hiroyuki Kojima, Katsuhiro Kawaai, Katsuhiko Mikoshiba, Koichi Hamada, Akihiro Mizutani
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/d559a802affd44caa044cb922f75ff21
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https://doaj.org/article/d559a802affd44caa044cb922f75ff21

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