Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

Ribosomal DNA transcription is essential for cell growth and division. Here, the authors show that EMT is accompanied by Snail binding to rDNA operons and Rictor association with nucleoli to fuel an induction of ribosome biogenesis during G1/S cell cycle arrest and inhibition of ribosome biogenesis...

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Autores principales: Varsha Prakash, Brittany B. Carson, Jennifer M. Feenstra, Randall A. Dass, Petra Sekyrova, Ayuko Hoshino, Julian Petersen, Yuan Guo, Matthew M. Parks, Chad M. Kurylo, Jake E. Batchelder, Kristian Haller, Ayako Hashimoto, Helene Rundqivst, John S. Condeelis, C. David Allis, Denis Drygin, M. Angela Nieto, Michael Andäng, Piergiorgio Percipalle, Jonas Bergh, Igor Adameyko, Ann-Kristin Östlund Farrants, Johan Hartman, David Lyden, Kristian Pietras, Scott C. Blanchard, C. Theresa Vincent
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/d55a3dcbab384f5da902c83d1a827b47
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spelling oai:doaj.org-article:d55a3dcbab384f5da902c83d1a827b472021-12-02T15:36:00ZRibosome biogenesis during cell cycle arrest fuels EMT in development and disease10.1038/s41467-019-10100-82041-1723https://doaj.org/article/d55a3dcbab384f5da902c83d1a827b472019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10100-8https://doaj.org/toc/2041-1723Ribosomal DNA transcription is essential for cell growth and division. Here, the authors show that EMT is accompanied by Snail binding to rDNA operons and Rictor association with nucleoli to fuel an induction of ribosome biogenesis during G1/S cell cycle arrest and inhibition of ribosome biogenesis hampers EMT, differentiates primary tumors and reduces metastasis.Varsha PrakashBrittany B. CarsonJennifer M. FeenstraRandall A. DassPetra SekyrovaAyuko HoshinoJulian PetersenYuan GuoMatthew M. ParksChad M. KuryloJake E. BatchelderKristian HallerAyako HashimotoHelene RundqivstJohn S. CondeelisC. David AllisDenis DryginM. Angela NietoMichael AndängPiergiorgio PercipalleJonas BerghIgor AdameykoAnn-Kristin Östlund FarrantsJohan HartmanDavid LydenKristian PietrasScott C. BlanchardC. Theresa VincentNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Varsha Prakash
Brittany B. Carson
Jennifer M. Feenstra
Randall A. Dass
Petra Sekyrova
Ayuko Hoshino
Julian Petersen
Yuan Guo
Matthew M. Parks
Chad M. Kurylo
Jake E. Batchelder
Kristian Haller
Ayako Hashimoto
Helene Rundqivst
John S. Condeelis
C. David Allis
Denis Drygin
M. Angela Nieto
Michael Andäng
Piergiorgio Percipalle
Jonas Bergh
Igor Adameyko
Ann-Kristin Östlund Farrants
Johan Hartman
David Lyden
Kristian Pietras
Scott C. Blanchard
C. Theresa Vincent
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
description Ribosomal DNA transcription is essential for cell growth and division. Here, the authors show that EMT is accompanied by Snail binding to rDNA operons and Rictor association with nucleoli to fuel an induction of ribosome biogenesis during G1/S cell cycle arrest and inhibition of ribosome biogenesis hampers EMT, differentiates primary tumors and reduces metastasis.
format article
author Varsha Prakash
Brittany B. Carson
Jennifer M. Feenstra
Randall A. Dass
Petra Sekyrova
Ayuko Hoshino
Julian Petersen
Yuan Guo
Matthew M. Parks
Chad M. Kurylo
Jake E. Batchelder
Kristian Haller
Ayako Hashimoto
Helene Rundqivst
John S. Condeelis
C. David Allis
Denis Drygin
M. Angela Nieto
Michael Andäng
Piergiorgio Percipalle
Jonas Bergh
Igor Adameyko
Ann-Kristin Östlund Farrants
Johan Hartman
David Lyden
Kristian Pietras
Scott C. Blanchard
C. Theresa Vincent
author_facet Varsha Prakash
Brittany B. Carson
Jennifer M. Feenstra
Randall A. Dass
Petra Sekyrova
Ayuko Hoshino
Julian Petersen
Yuan Guo
Matthew M. Parks
Chad M. Kurylo
Jake E. Batchelder
Kristian Haller
Ayako Hashimoto
Helene Rundqivst
John S. Condeelis
C. David Allis
Denis Drygin
M. Angela Nieto
Michael Andäng
Piergiorgio Percipalle
Jonas Bergh
Igor Adameyko
Ann-Kristin Östlund Farrants
Johan Hartman
David Lyden
Kristian Pietras
Scott C. Blanchard
C. Theresa Vincent
author_sort Varsha Prakash
title Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
title_short Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
title_full Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
title_fullStr Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
title_full_unstemmed Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
title_sort ribosome biogenesis during cell cycle arrest fuels emt in development and disease
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/d55a3dcbab384f5da902c83d1a827b47
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