Homocysteine and familial longevity: the Leiden Longevity Study.

Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease. We aimed to explore the association of homocysteine with familial longevit...

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Autores principales:	Carolien A Wijsman, Diana van Heemst, Maarten P Rozing, P Eline Slagboom, Marian Beekman, Anton J M de Craen, Andrea B Maier, Rudi G J Westendorp, Henk J Blom, Simon P Mooijaart
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d55aac3704d84ae38a119907369dc656
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spelling	oai:doaj.org-article:d55aac3704d84ae38a119907369dc6562021-11-18T06:57:37ZHomocysteine and familial longevity: the Leiden Longevity Study.1932-620310.1371/journal.pone.0017543https://doaj.org/article/d55aac3704d84ae38a119907369dc6562011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21408159/?tool=EBIhttps://doaj.org/toc/1932-6203Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease. We aimed to explore the association of homocysteine with familial longevity by testing whether homocysteine is lower in individuals that are genetically enriched for longevity. We measured concentrations of total homocysteine in 1907 subjects from the Leiden Longevity Study consisting of 1309 offspring of nonagenarian siblings, who are enriched with familial factors promoting longevity, and 598 partners thereof as population controls. We found that homocysteine was related to age, creatinine, folate, vitamin B levels and medical history of hypertension and stroke in both groups (all p<0.001). However, levels of homocysteine did not differ between offspring enriched for longevity and their partners, and no differences in the age-related rise in homocysteine levels were found between groups (p for interaction 0.63). The results suggest that homocysteine metabolism is not likely to predict familial longevity.Carolien A WijsmanDiana van HeemstMaarten P RozingP Eline SlagboomMarian BeekmanAnton J M de CraenAndrea B MaierRudi G J WestendorpHenk J BlomSimon P MooijaartPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e17543 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carolien A Wijsman Diana van Heemst Maarten P Rozing P Eline Slagboom Marian Beekman Anton J M de Craen Andrea B Maier Rudi G J Westendorp Henk J Blom Simon P Mooijaart Homocysteine and familial longevity: the Leiden Longevity Study.
description	Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease. We aimed to explore the association of homocysteine with familial longevity by testing whether homocysteine is lower in individuals that are genetically enriched for longevity. We measured concentrations of total homocysteine in 1907 subjects from the Leiden Longevity Study consisting of 1309 offspring of nonagenarian siblings, who are enriched with familial factors promoting longevity, and 598 partners thereof as population controls. We found that homocysteine was related to age, creatinine, folate, vitamin B levels and medical history of hypertension and stroke in both groups (all p<0.001). However, levels of homocysteine did not differ between offspring enriched for longevity and their partners, and no differences in the age-related rise in homocysteine levels were found between groups (p for interaction 0.63). The results suggest that homocysteine metabolism is not likely to predict familial longevity.
format	article
author	Carolien A Wijsman Diana van Heemst Maarten P Rozing P Eline Slagboom Marian Beekman Anton J M de Craen Andrea B Maier Rudi G J Westendorp Henk J Blom Simon P Mooijaart
author_facet	Carolien A Wijsman Diana van Heemst Maarten P Rozing P Eline Slagboom Marian Beekman Anton J M de Craen Andrea B Maier Rudi G J Westendorp Henk J Blom Simon P Mooijaart
author_sort	Carolien A Wijsman
title	Homocysteine and familial longevity: the Leiden Longevity Study.
title_short	Homocysteine and familial longevity: the Leiden Longevity Study.
title_full	Homocysteine and familial longevity: the Leiden Longevity Study.
title_fullStr	Homocysteine and familial longevity: the Leiden Longevity Study.
title_full_unstemmed	Homocysteine and familial longevity: the Leiden Longevity Study.
title_sort	homocysteine and familial longevity: the leiden longevity study.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/d55aac3704d84ae38a119907369dc656
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Homocysteine and familial longevity: the Leiden Longevity Study.

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