Systematic Analysis of FASTK Gene Family Alterations in Cancer

The FASTK family of proteins have been recently reported to play a key role in the post-transcriptional regulation of mitochondrial gene expression, including mRNA stability and translation. Accumulated studies have provided evidence that the expression of some FASTK genes is altered in certain type...

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Autores principales:	Lorena Magraner-Pardo, Dino Gobelli, Miguel A. de la Fuente, Tirso Pons, María Simarro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mitochondria FASTK cancer genetic alterations Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d55c659c6dd2424b82408f0090063b97
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spelling	oai:doaj.org-article:d55c659c6dd2424b82408f0090063b972021-11-11T16:49:21ZSystematic Analysis of FASTK Gene Family Alterations in Cancer10.3390/ijms2221113371422-00671661-6596https://doaj.org/article/d55c659c6dd2424b82408f0090063b972021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11337https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The FASTK family of proteins have been recently reported to play a key role in the post-transcriptional regulation of mitochondrial gene expression, including mRNA stability and translation. Accumulated studies have provided evidence that the expression of some FASTK genes is altered in certain types of cancer, in agreement with the central role of mitochondria in cancer development. Here, we obtained a pan-cancer overview of the genomic and transcriptomic alterations of FASTK genes. FASTK, FASTKD1, FASTKD3 and FASTKD5 showed the highest rates of genetic alterations. FASTK and FASTKD3 alterations consisted mainly of amplifications that were seen in more than 8% of ovarian and lung cancers, respectively. FASTKD1 and FASTKD5 were the most frequently mutated FASTK genes, and the mutations were identified in 5–7% of uterine cancers, as well as in 4% of melanomas. Our results also showed that the mRNA levels of all FASTK members were strongly upregulated in esophageal, stomach, liver and lung cancers. Finally, the protein-protein interaction network for FASTK proteins uncovers the interaction of FASTK, FASTKD2, FASTKD4 and FASTKD5 with cancer signaling pathways. These results serve as a starting point for future research into the potential of the FASTK family members as diagnostic and therapeutic targets for certain types of cancer.Lorena Magraner-PardoDino GobelliMiguel A. de la FuenteTirso PonsMaría SimarroMDPI AGarticlemitochondriaFASTKcancergenetic alterationsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11337, p 11337 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondria FASTK cancer genetic alterations Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mitochondria FASTK cancer genetic alterations Biology (General) QH301-705.5 Chemistry QD1-999 Lorena Magraner-Pardo Dino Gobelli Miguel A. de la Fuente Tirso Pons María Simarro Systematic Analysis of FASTK Gene Family Alterations in Cancer
description	The FASTK family of proteins have been recently reported to play a key role in the post-transcriptional regulation of mitochondrial gene expression, including mRNA stability and translation. Accumulated studies have provided evidence that the expression of some FASTK genes is altered in certain types of cancer, in agreement with the central role of mitochondria in cancer development. Here, we obtained a pan-cancer overview of the genomic and transcriptomic alterations of FASTK genes. FASTK, FASTKD1, FASTKD3 and FASTKD5 showed the highest rates of genetic alterations. FASTK and FASTKD3 alterations consisted mainly of amplifications that were seen in more than 8% of ovarian and lung cancers, respectively. FASTKD1 and FASTKD5 were the most frequently mutated FASTK genes, and the mutations were identified in 5–7% of uterine cancers, as well as in 4% of melanomas. Our results also showed that the mRNA levels of all FASTK members were strongly upregulated in esophageal, stomach, liver and lung cancers. Finally, the protein-protein interaction network for FASTK proteins uncovers the interaction of FASTK, FASTKD2, FASTKD4 and FASTKD5 with cancer signaling pathways. These results serve as a starting point for future research into the potential of the FASTK family members as diagnostic and therapeutic targets for certain types of cancer.
format	article
author	Lorena Magraner-Pardo Dino Gobelli Miguel A. de la Fuente Tirso Pons María Simarro
author_facet	Lorena Magraner-Pardo Dino Gobelli Miguel A. de la Fuente Tirso Pons María Simarro
author_sort	Lorena Magraner-Pardo
title	Systematic Analysis of FASTK Gene Family Alterations in Cancer
title_short	Systematic Analysis of FASTK Gene Family Alterations in Cancer
title_full	Systematic Analysis of FASTK Gene Family Alterations in Cancer
title_fullStr	Systematic Analysis of FASTK Gene Family Alterations in Cancer
title_full_unstemmed	Systematic Analysis of FASTK Gene Family Alterations in Cancer
title_sort	systematic analysis of fastk gene family alterations in cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d55c659c6dd2424b82408f0090063b97
work_keys_str_mv	AT lorenamagranerpardo systematicanalysisoffastkgenefamilyalterationsincancer AT dinogobelli systematicanalysisoffastkgenefamilyalterationsincancer AT migueladelafuente systematicanalysisoffastkgenefamilyalterationsincancer AT tirsopons systematicanalysisoffastkgenefamilyalterationsincancer AT mariasimarro systematicanalysisoffastkgenefamilyalterationsincancer
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Systematic Analysis of FASTK Gene Family Alterations in Cancer

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