Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats

Abstract Phytoestrogen-rich soy is known to ameliorate menopause-associated obesity and metabolic dysfunction for reasons that are unclear. The gut microbiota have been linked with the development of obesity and metabolic dysfunction. We aimed to determine the impact of soy on cardiometabolic health...

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Autores principales:	Tzu-Wen L. Cross, Terese M. Zidon, Rebecca J. Welly, Young-Min Park, Steven L. Britton, Lauren G. Koch, George E. Rottinghaus, Maria R. Cattai de Godoy, Jaume Padilla, Kelly S. Swanson, Victoria J. Vieira-Potter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d55dbdb02d1c432ead7abd269772511f
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spelling	oai:doaj.org-article:d55dbdb02d1c432ead7abd269772511f2021-12-02T15:06:02ZSoy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats10.1038/s41598-017-08965-02045-2322https://doaj.org/article/d55dbdb02d1c432ead7abd269772511f2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08965-0https://doaj.org/toc/2045-2322Abstract Phytoestrogen-rich soy is known to ameliorate menopause-associated obesity and metabolic dysfunction for reasons that are unclear. The gut microbiota have been linked with the development of obesity and metabolic dysfunction. We aimed to determine the impact of soy on cardiometabolic health, adipose tissue inflammation, and the cecal microbiota in ovariectomized (OVX) rats bred for low-running capacity (LCR), a model that has been previously shown to mimic human menopause compared to sham-operated (SHM) intact control LCR rats. In this study, soy consumption, without affecting energy intake or physical activity, significantly improved insulin sensitivity and body composition of OVX rats bred for low-running capacity. Furthermore, soy significantly improved blood lipid profile, adipose tissue inflammation, and aortic stiffness of LCR rats. Compared to a soy-free control diet, soy significantly shifted the cecal microbial community of LCR rats, resulting in a lower Firmicutes:Bacteroidetes ratio. Correlations among metabolic parameters and cecal bacterial taxa identified in this study suggest that taxa Prevotella, Dorea, and Phascolarctobacterium may be taxa of interest. Our results suggest that dietary soy ameliorates adiposity, insulin sensitivity, adipose tissue inflammation, and arterial stiffness and exerts a beneficial shift in gut microbial communities in a rat model that mimics human menopause.Tzu-Wen L. CrossTerese M. ZidonRebecca J. WellyYoung-Min ParkSteven L. BrittonLauren G. KochGeorge E. RottinghausMaria R. Cattai de GodoyJaume PadillaKelly S. SwansonVictoria J. Vieira-PotterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tzu-Wen L. Cross Terese M. Zidon Rebecca J. Welly Young-Min Park Steven L. Britton Lauren G. Koch George E. Rottinghaus Maria R. Cattai de Godoy Jaume Padilla Kelly S. Swanson Victoria J. Vieira-Potter Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats
description	Abstract Phytoestrogen-rich soy is known to ameliorate menopause-associated obesity and metabolic dysfunction for reasons that are unclear. The gut microbiota have been linked with the development of obesity and metabolic dysfunction. We aimed to determine the impact of soy on cardiometabolic health, adipose tissue inflammation, and the cecal microbiota in ovariectomized (OVX) rats bred for low-running capacity (LCR), a model that has been previously shown to mimic human menopause compared to sham-operated (SHM) intact control LCR rats. In this study, soy consumption, without affecting energy intake or physical activity, significantly improved insulin sensitivity and body composition of OVX rats bred for low-running capacity. Furthermore, soy significantly improved blood lipid profile, adipose tissue inflammation, and aortic stiffness of LCR rats. Compared to a soy-free control diet, soy significantly shifted the cecal microbial community of LCR rats, resulting in a lower Firmicutes:Bacteroidetes ratio. Correlations among metabolic parameters and cecal bacterial taxa identified in this study suggest that taxa Prevotella, Dorea, and Phascolarctobacterium may be taxa of interest. Our results suggest that dietary soy ameliorates adiposity, insulin sensitivity, adipose tissue inflammation, and arterial stiffness and exerts a beneficial shift in gut microbial communities in a rat model that mimics human menopause.
format	article
author	Tzu-Wen L. Cross Terese M. Zidon Rebecca J. Welly Young-Min Park Steven L. Britton Lauren G. Koch George E. Rottinghaus Maria R. Cattai de Godoy Jaume Padilla Kelly S. Swanson Victoria J. Vieira-Potter
author_facet	Tzu-Wen L. Cross Terese M. Zidon Rebecca J. Welly Young-Min Park Steven L. Britton Lauren G. Koch George E. Rottinghaus Maria R. Cattai de Godoy Jaume Padilla Kelly S. Swanson Victoria J. Vieira-Potter
author_sort	Tzu-Wen L. Cross
title	Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats
title_short	Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats
title_full	Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats
title_fullStr	Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats
title_full_unstemmed	Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats
title_sort	soy improves cardiometabolic health and cecal microbiota in female low-fit rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d55dbdb02d1c432ead7abd269772511f
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Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats

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