AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing
IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK-dependent pathway.
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2021
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oai:doaj.org-article:d561adaf19ee4c4ab175614033a5dedb2021-12-02T16:30:15ZAKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing10.1038/s41467-021-24795-12041-1723https://doaj.org/article/d561adaf19ee4c4ab175614033a5dedb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24795-1https://doaj.org/toc/2041-1723IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK-dependent pathway.Georgios I. LaliotisEvangelia ChavdoulaMaria D. ParaskevopoulouAbdul KabaAlessandro La FerlitaSatishkumar SinghVollter AnastasKeith A. NairArturo OrlacchioVasiliki TarasliaIoannis VlachosMarina CapeceArtemis HatzigeorgiouDario PalmieriChristos TsatsanisSalvatore AlaimoLalit SehgalDavid P. CarboneVincenzo CoppolaPhilip N. TsichlisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-25 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Georgios I. Laliotis Evangelia Chavdoula Maria D. Paraskevopoulou Abdul Kaba Alessandro La Ferlita Satishkumar Singh Vollter Anastas Keith A. Nair Arturo Orlacchio Vasiliki Taraslia Ioannis Vlachos Marina Capece Artemis Hatzigeorgiou Dario Palmieri Christos Tsatsanis Salvatore Alaimo Lalit Sehgal David P. Carbone Vincenzo Coppola Philip N. Tsichlis AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing |
| description |
IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK-dependent pathway. |
| format |
article |
| author |
Georgios I. Laliotis Evangelia Chavdoula Maria D. Paraskevopoulou Abdul Kaba Alessandro La Ferlita Satishkumar Singh Vollter Anastas Keith A. Nair Arturo Orlacchio Vasiliki Taraslia Ioannis Vlachos Marina Capece Artemis Hatzigeorgiou Dario Palmieri Christos Tsatsanis Salvatore Alaimo Lalit Sehgal David P. Carbone Vincenzo Coppola Philip N. Tsichlis |
| author_facet |
Georgios I. Laliotis Evangelia Chavdoula Maria D. Paraskevopoulou Abdul Kaba Alessandro La Ferlita Satishkumar Singh Vollter Anastas Keith A. Nair Arturo Orlacchio Vasiliki Taraslia Ioannis Vlachos Marina Capece Artemis Hatzigeorgiou Dario Palmieri Christos Tsatsanis Salvatore Alaimo Lalit Sehgal David P. Carbone Vincenzo Coppola Philip N. Tsichlis |
| author_sort |
Georgios I. Laliotis |
| title |
AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing |
| title_short |
AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing |
| title_full |
AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing |
| title_fullStr |
AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing |
| title_full_unstemmed |
AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing |
| title_sort |
akt3-mediated iws1 phosphorylation promotes the proliferation of egfr-mutant lung adenocarcinomas through cell cycle-regulated u2af2 rna splicing |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d561adaf19ee4c4ab175614033a5dedb |
| work_keys_str_mv |
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