Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export
The bacterial RND superfamily of efflux pumps mediate resistance to a variety of biocides, including Cu(I) and Ag(I) ions. Here we report four cryo-EM structures of the trimeric CusA pump in the presence of Cu(I). Combined with MD simulations, our data indicate that each CusA protomer within the tr...
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| Main Authors: | , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/d5623e1c81b943f792bc80254cdda644 |
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