TRIM29 promotes DNA virus infections by inhibiting innate immune response

Proteins of the TRIM family have regulatory functions in immune signaling, often via ubiquitination of target proteins. Here, the authors show that TRIM29 is induced upon infection with DNA viruses, resulting in degradation of STING, decreased interferon signaling and increased pathogenicity in mice...

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Autores principales:	Junji Xing, Ao Zhang, Hua Zhang, Jin Wang, Xian Chang Li, Mu-Sheng Zeng, Zhiqiang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d562b06923eb4f768531d624223a11f4
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spelling	oai:doaj.org-article:d562b06923eb4f768531d624223a11f42021-12-02T15:37:05ZTRIM29 promotes DNA virus infections by inhibiting innate immune response10.1038/s41467-017-00101-w2041-1723https://doaj.org/article/d562b06923eb4f768531d624223a11f42017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00101-whttps://doaj.org/toc/2041-1723Proteins of the TRIM family have regulatory functions in immune signaling, often via ubiquitination of target proteins. Here, the authors show that TRIM29 is induced upon infection with DNA viruses, resulting in degradation of STING, decreased interferon signaling and increased pathogenicity in mice.Junji XingAo ZhangHua ZhangJin WangXian Chang LiMu-Sheng ZengZhiqiang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junji Xing Ao Zhang Hua Zhang Jin Wang Xian Chang Li Mu-Sheng Zeng Zhiqiang Zhang TRIM29 promotes DNA virus infections by inhibiting innate immune response
description	Proteins of the TRIM family have regulatory functions in immune signaling, often via ubiquitination of target proteins. Here, the authors show that TRIM29 is induced upon infection with DNA viruses, resulting in degradation of STING, decreased interferon signaling and increased pathogenicity in mice.
format	article
author	Junji Xing Ao Zhang Hua Zhang Jin Wang Xian Chang Li Mu-Sheng Zeng Zhiqiang Zhang
author_facet	Junji Xing Ao Zhang Hua Zhang Jin Wang Xian Chang Li Mu-Sheng Zeng Zhiqiang Zhang
author_sort	Junji Xing
title	TRIM29 promotes DNA virus infections by inhibiting innate immune response
title_short	TRIM29 promotes DNA virus infections by inhibiting innate immune response
title_full	TRIM29 promotes DNA virus infections by inhibiting innate immune response
title_fullStr	TRIM29 promotes DNA virus infections by inhibiting innate immune response
title_full_unstemmed	TRIM29 promotes DNA virus infections by inhibiting innate immune response
title_sort	trim29 promotes dna virus infections by inhibiting innate immune response
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d562b06923eb4f768531d624223a11f4
work_keys_str_mv	AT junjixing trim29promotesdnavirusinfectionsbyinhibitinginnateimmuneresponse AT aozhang trim29promotesdnavirusinfectionsbyinhibitinginnateimmuneresponse AT huazhang trim29promotesdnavirusinfectionsbyinhibitinginnateimmuneresponse AT jinwang trim29promotesdnavirusinfectionsbyinhibitinginnateimmuneresponse AT xianchangli trim29promotesdnavirusinfectionsbyinhibitinginnateimmuneresponse AT mushengzeng trim29promotesdnavirusinfectionsbyinhibitinginnateimmuneresponse AT zhiqiangzhang trim29promotesdnavirusinfectionsbyinhibitinginnateimmuneresponse
_version_	1718386261356445696

TRIM29 promotes DNA virus infections by inhibiting innate immune response

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