The Effects of Endocrine Therapies on Lipid Profiles in Chinese Young Women With Early Breast Cancer

This study aimed to evaluate and compare the effects of various endocrine therapies on lipid profiles in young patients with breast cancer. A retrospective, single-center study was performed to investigate the effects of tamoxifen (TAM), tamoxifen plus ovarian function suppression (TAM+OFS), and aro...

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Autores principales:	Yi-Kun Kang, Xue Wang, Nan-Lin Hu, Jian Yue, Yi-Ran Si, Jie Ju, Song-Lin Gao, Peng Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	endocrine therapy lipid breast cancer premenopausal ovarian function suppression Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d565b46f58e94209ae692e62c04d97b9
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spelling	oai:doaj.org-article:d565b46f58e94209ae692e62c04d97b92021-12-01T21:24:04ZThe Effects of Endocrine Therapies on Lipid Profiles in Chinese Young Women With Early Breast Cancer2234-943X10.3389/fonc.2021.759595https://doaj.org/article/d565b46f58e94209ae692e62c04d97b92021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.759595/fullhttps://doaj.org/toc/2234-943XThis study aimed to evaluate and compare the effects of various endocrine therapies on lipid profiles in young patients with breast cancer. A retrospective, single-center study was performed to investigate the effects of tamoxifen (TAM), tamoxifen plus ovarian function suppression (TAM+OFS), and aromatase inhibitors plus ovarian function suppression (AI+OFS) on lipid profiles during the 60 months of endocrine therapy in hormone receptor-positive patients aged <40 with early breast cancer. The primary endpoint was the cumulative incidence of lipid events, and the secondary endpoints were the changes in lipid profiles. A total of 230 young patients were included with the mean age of 35.7 years old. The patients in TAM group had significantly lower incidence of 5-year lipid events than those in TAM+OFS group (7.4% versus 21.3%; P=0.016) and AI+OFS group (7.4% versus 21.6%; P=0.009). The incidence of fatty liver was significantly higher in TAM+OFS group than TAM group (52.5%versus 30.9%; P=0.043). Lipid events were associated with younger age (odds ratio (OR)=0.865, 95% confidence interval (CI): 0.780-0960; P=0.006), higher baseline LDL-C (OR=14.959, 95% CI: 4.379-51.105; P<0.001), and use of OFS (OR=3.557, 95% CI: 1.151-10.989; P=0.027). Therefore, application of OFS, with younger age and higher baseline LDL-C, may increase the incidence of lipid events in premenopausal breast cancer. More care should be taken for lipid profiles during the endocrine therapy for young breast cancer patients.Yi-Kun KangXue WangNan-Lin HuJian YueYi-Ran SiJie JuSong-Lin GaoPeng YuanFrontiers Media S.A.articleendocrine therapylipidbreast cancerpremenopausalovarian function suppressionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endocrine therapy lipid breast cancer premenopausal ovarian function suppression Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	endocrine therapy lipid breast cancer premenopausal ovarian function suppression Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yi-Kun Kang Xue Wang Nan-Lin Hu Jian Yue Yi-Ran Si Jie Ju Song-Lin Gao Peng Yuan The Effects of Endocrine Therapies on Lipid Profiles in Chinese Young Women With Early Breast Cancer
description	This study aimed to evaluate and compare the effects of various endocrine therapies on lipid profiles in young patients with breast cancer. A retrospective, single-center study was performed to investigate the effects of tamoxifen (TAM), tamoxifen plus ovarian function suppression (TAM+OFS), and aromatase inhibitors plus ovarian function suppression (AI+OFS) on lipid profiles during the 60 months of endocrine therapy in hormone receptor-positive patients aged <40 with early breast cancer. The primary endpoint was the cumulative incidence of lipid events, and the secondary endpoints were the changes in lipid profiles. A total of 230 young patients were included with the mean age of 35.7 years old. The patients in TAM group had significantly lower incidence of 5-year lipid events than those in TAM+OFS group (7.4% versus 21.3%; P=0.016) and AI+OFS group (7.4% versus 21.6%; P=0.009). The incidence of fatty liver was significantly higher in TAM+OFS group than TAM group (52.5%versus 30.9%; P=0.043). Lipid events were associated with younger age (odds ratio (OR)=0.865, 95% confidence interval (CI): 0.780-0960; P=0.006), higher baseline LDL-C (OR=14.959, 95% CI: 4.379-51.105; P<0.001), and use of OFS (OR=3.557, 95% CI: 1.151-10.989; P=0.027). Therefore, application of OFS, with younger age and higher baseline LDL-C, may increase the incidence of lipid events in premenopausal breast cancer. More care should be taken for lipid profiles during the endocrine therapy for young breast cancer patients.
format	article
author	Yi-Kun Kang Xue Wang Nan-Lin Hu Jian Yue Yi-Ran Si Jie Ju Song-Lin Gao Peng Yuan
author_facet	Yi-Kun Kang Xue Wang Nan-Lin Hu Jian Yue Yi-Ran Si Jie Ju Song-Lin Gao Peng Yuan
author_sort	Yi-Kun Kang
title	The Effects of Endocrine Therapies on Lipid Profiles in Chinese Young Women With Early Breast Cancer
title_short	The Effects of Endocrine Therapies on Lipid Profiles in Chinese Young Women With Early Breast Cancer
title_full	The Effects of Endocrine Therapies on Lipid Profiles in Chinese Young Women With Early Breast Cancer
title_fullStr	The Effects of Endocrine Therapies on Lipid Profiles in Chinese Young Women With Early Breast Cancer
title_full_unstemmed	The Effects of Endocrine Therapies on Lipid Profiles in Chinese Young Women With Early Breast Cancer
title_sort	effects of endocrine therapies on lipid profiles in chinese young women with early breast cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d565b46f58e94209ae692e62c04d97b9
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The Effects of Endocrine Therapies on Lipid Profiles in Chinese Young Women With Early Breast Cancer

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