Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study

Background: China has the largest disease burden of hepatitis B virus (HBV) infection and is considered as a major contributor to the global elimination of hepatitis B by 2030. However, the national prevalence of HBV infection among Chinese pregnant women was not reported yet. We evaluated the natio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jue Liu, Xiaoyan Wang, Qian Wang, Yaping Qiao, Xi Jin, Zhixin Li, Min Du, Wenxin Yan, Wenzhan Jing, Min Liu, Ailing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/d5666677cf024b40bbeb5369f054111b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d5666677cf024b40bbeb5369f054111b
record_format	dspace
spelling	oai:doaj.org-article:d5666677cf024b40bbeb5369f054111b2021-12-02T05:04:04ZHepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study2666-606510.1016/j.lanwpc.2021.100267https://doaj.org/article/d5666677cf024b40bbeb5369f054111b2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666606521001760https://doaj.org/toc/2666-6065Background: China has the largest disease burden of hepatitis B virus (HBV) infection and is considered as a major contributor to the global elimination of hepatitis B by 2030. However, the national prevalence of HBV infection among Chinese pregnant women was not reported yet. We evaluated the national and regional prevalence of HBV infection among pregnant women in China between 2015-2020, aiming to provide the latest baseline data. Methods: We assessed the prevalence of HBV infection from data gathered through a nationwide cross-sectional study of Chinese pregnant women. Data were obtained from the National Integrated Prevention of Mother-to-Child Transmission of HIV, Syphilis and Hepatitis B Programme (iPMTCT Programme) in China, which covered all the 2856 counties from 31 provinces from 2015 to 2020. HBV infection was defined as being tested seropositive for hepatitis B surface antigen (HBsAg). Findings: A total of 90.87 million pregnant women in mainland China were testing for HBV between 2015 and 2020, with 5.60 million (6.17%, 95%CI: 6.16-6.18%) tested positive for HBsAg. From 2015 to 2020, the prevalence of HBV infection among pregnant women declined by 25.44%, from 7.30% in 2015 to 5.44% in 2020 (p for trend < 0.001), with an estimated annual percentage change (EAPC) of -5.27% (95% CI: -3.19% to -7.32%). Compared with the prevalence in 2015, reginal disparities in eastern, central, and western China were narrowed. Declines were also observed at provincial level and county level. HBV prevalence declined in most provinces (90.3%, 28/31) and counties (76.96%, 2198/2856) from 2015 to 2020. However, disparities still exist. Interpretation: HBV prevalence in pregnant women in China was intermediate endemic and declined continuously from 2015 to 2020. The decline has been widespread across regions, but disparities remain. Regions with relatively higher disease burden on HBV infection should receive most attention in achieving the 2030 elimination goals. Funding: National Natural Science Foundation of ChinaJue LiuXiaoyan WangQian WangYaping QiaoXi JinZhixin LiMin DuWenxin YanWenzhan JingMin LiuAiling WangElsevierarticlePublic aspects of medicineRA1-1270ENThe Lancet Regional Health. Western Pacific, Vol 16, Iss , Pp 100267- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Public aspects of medicine RA1-1270
spellingShingle	Public aspects of medicine RA1-1270 Jue Liu Xiaoyan Wang Qian Wang Yaping Qiao Xi Jin Zhixin Li Min Du Wenxin Yan Wenzhan Jing Min Liu Ailing Wang Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study
description	Background: China has the largest disease burden of hepatitis B virus (HBV) infection and is considered as a major contributor to the global elimination of hepatitis B by 2030. However, the national prevalence of HBV infection among Chinese pregnant women was not reported yet. We evaluated the national and regional prevalence of HBV infection among pregnant women in China between 2015-2020, aiming to provide the latest baseline data. Methods: We assessed the prevalence of HBV infection from data gathered through a nationwide cross-sectional study of Chinese pregnant women. Data were obtained from the National Integrated Prevention of Mother-to-Child Transmission of HIV, Syphilis and Hepatitis B Programme (iPMTCT Programme) in China, which covered all the 2856 counties from 31 provinces from 2015 to 2020. HBV infection was defined as being tested seropositive for hepatitis B surface antigen (HBsAg). Findings: A total of 90.87 million pregnant women in mainland China were testing for HBV between 2015 and 2020, with 5.60 million (6.17%, 95%CI: 6.16-6.18%) tested positive for HBsAg. From 2015 to 2020, the prevalence of HBV infection among pregnant women declined by 25.44%, from 7.30% in 2015 to 5.44% in 2020 (p for trend < 0.001), with an estimated annual percentage change (EAPC) of -5.27% (95% CI: -3.19% to -7.32%). Compared with the prevalence in 2015, reginal disparities in eastern, central, and western China were narrowed. Declines were also observed at provincial level and county level. HBV prevalence declined in most provinces (90.3%, 28/31) and counties (76.96%, 2198/2856) from 2015 to 2020. However, disparities still exist. Interpretation: HBV prevalence in pregnant women in China was intermediate endemic and declined continuously from 2015 to 2020. The decline has been widespread across regions, but disparities remain. Regions with relatively higher disease burden on HBV infection should receive most attention in achieving the 2030 elimination goals. Funding: National Natural Science Foundation of China
format	article
author	Jue Liu Xiaoyan Wang Qian Wang Yaping Qiao Xi Jin Zhixin Li Min Du Wenxin Yan Wenzhan Jing Min Liu Ailing Wang
author_facet	Jue Liu Xiaoyan Wang Qian Wang Yaping Qiao Xi Jin Zhixin Li Min Du Wenxin Yan Wenzhan Jing Min Liu Ailing Wang
author_sort	Jue Liu
title	Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study
title_short	Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study
title_full	Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study
title_fullStr	Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study
title_full_unstemmed	Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study
title_sort	hepatitis b virus infection among 90 million pregnant women in 2853 chinese counties, 2015-2020: a national observational study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d5666677cf024b40bbeb5369f054111b
work_keys_str_mv	AT jueliu hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy AT xiaoyanwang hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy AT qianwang hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy AT yapingqiao hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy AT xijin hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy AT zhixinli hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy AT mindu hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy AT wenxinyan hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy AT wenzhanjing hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy AT minliu hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy AT ailingwang hepatitisbvirusinfectionamong90millionpregnantwomenin2853chinesecounties20152020anationalobservationalstudy
_version_	1718400679278542848

Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study

Ejemplares similares