Novel Interventional Management of Hepatic Hydatid Cyst with Nanosecond Pulses on Experimental Mouse Model

Abstract The nanosecond pulsed electric field (nsPEF) is investigated as an alternative plan for benign hepatic hydatid cyst. Altogether 72 C57B6 mice were included. Normal group (n = 12) had no parasite injection and the other 60 mice were used to induce hydatid cyst in liver by injecting protoscol...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xinhua Chen, Ruiqing Zhang, Tuerganaili Aji, Yingmei Shao, Yonggang Chen, Hao Wen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d5674b9a37b245699464148fb41fb2b5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d5674b9a37b245699464148fb41fb2b5
record_format	dspace
spelling	oai:doaj.org-article:d5674b9a37b245699464148fb41fb2b52021-12-02T12:31:47ZNovel Interventional Management of Hepatic Hydatid Cyst with Nanosecond Pulses on Experimental Mouse Model10.1038/s41598-017-04873-52045-2322https://doaj.org/article/d5674b9a37b245699464148fb41fb2b52017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04873-5https://doaj.org/toc/2045-2322Abstract The nanosecond pulsed electric field (nsPEF) is investigated as an alternative plan for benign hepatic hydatid cyst. Altogether 72 C57B6 mice were included. Normal group (n = 12) had no parasite injection and the other 60 mice were used to induce hydatid cyst in liver by injecting protoscolices in portal vein. The liver hydatid cysts were exposed to nsPEF with different doses and then follow up. The standard surgery was performed as positive control. The hydatid cyst growth was monitored by ultrasound; the morphology was checked by gross anatomy and pathology was tested by H&E stain. In nsPEF-treated groups no hepatic failure nor bleeding were observed. As a comparison, in the surgery group, high post-treatment complications occurred (50%). Significant parasite growth inhibition was seen in high nsPEF dose group as compared with control group (P < 0.05). Pathological analysis confirmed destruction of hydatid cyst with sharp demarcation defined by the electrodes. Laboratory analysis showed nsPEF stimulated a time-dependent infection and recoverable liver function. The traumatic reactions defined by white blood count was significant lower than surgery groups (P < 0.05).Preliminary studies demonstrate nsPEF ablation can be applied on hepatic hydatid by inhibiting parasite growth, destructing the cyst and stimulating infections.Xinhua ChenRuiqing ZhangTuerganaili AjiYingmei ShaoYonggang ChenHao WenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xinhua Chen Ruiqing Zhang Tuerganaili Aji Yingmei Shao Yonggang Chen Hao Wen Novel Interventional Management of Hepatic Hydatid Cyst with Nanosecond Pulses on Experimental Mouse Model
description	Abstract The nanosecond pulsed electric field (nsPEF) is investigated as an alternative plan for benign hepatic hydatid cyst. Altogether 72 C57B6 mice were included. Normal group (n = 12) had no parasite injection and the other 60 mice were used to induce hydatid cyst in liver by injecting protoscolices in portal vein. The liver hydatid cysts were exposed to nsPEF with different doses and then follow up. The standard surgery was performed as positive control. The hydatid cyst growth was monitored by ultrasound; the morphology was checked by gross anatomy and pathology was tested by H&E stain. In nsPEF-treated groups no hepatic failure nor bleeding were observed. As a comparison, in the surgery group, high post-treatment complications occurred (50%). Significant parasite growth inhibition was seen in high nsPEF dose group as compared with control group (P < 0.05). Pathological analysis confirmed destruction of hydatid cyst with sharp demarcation defined by the electrodes. Laboratory analysis showed nsPEF stimulated a time-dependent infection and recoverable liver function. The traumatic reactions defined by white blood count was significant lower than surgery groups (P < 0.05).Preliminary studies demonstrate nsPEF ablation can be applied on hepatic hydatid by inhibiting parasite growth, destructing the cyst and stimulating infections.
format	article
author	Xinhua Chen Ruiqing Zhang Tuerganaili Aji Yingmei Shao Yonggang Chen Hao Wen
author_facet	Xinhua Chen Ruiqing Zhang Tuerganaili Aji Yingmei Shao Yonggang Chen Hao Wen
author_sort	Xinhua Chen
title	Novel Interventional Management of Hepatic Hydatid Cyst with Nanosecond Pulses on Experimental Mouse Model
title_short	Novel Interventional Management of Hepatic Hydatid Cyst with Nanosecond Pulses on Experimental Mouse Model
title_full	Novel Interventional Management of Hepatic Hydatid Cyst with Nanosecond Pulses on Experimental Mouse Model
title_fullStr	Novel Interventional Management of Hepatic Hydatid Cyst with Nanosecond Pulses on Experimental Mouse Model
title_full_unstemmed	Novel Interventional Management of Hepatic Hydatid Cyst with Nanosecond Pulses on Experimental Mouse Model
title_sort	novel interventional management of hepatic hydatid cyst with nanosecond pulses on experimental mouse model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d5674b9a37b245699464148fb41fb2b5
work_keys_str_mv	AT xinhuachen novelinterventionalmanagementofhepatichydatidcystwithnanosecondpulsesonexperimentalmousemodel AT ruiqingzhang novelinterventionalmanagementofhepatichydatidcystwithnanosecondpulsesonexperimentalmousemodel AT tuerganailiaji novelinterventionalmanagementofhepatichydatidcystwithnanosecondpulsesonexperimentalmousemodel AT yingmeishao novelinterventionalmanagementofhepatichydatidcystwithnanosecondpulsesonexperimentalmousemodel AT yonggangchen novelinterventionalmanagementofhepatichydatidcystwithnanosecondpulsesonexperimentalmousemodel AT haowen novelinterventionalmanagementofhepatichydatidcystwithnanosecondpulsesonexperimentalmousemodel
_version_	1718394308711677952

Novel Interventional Management of Hepatic Hydatid Cyst with Nanosecond Pulses on Experimental Mouse Model

Ejemplares similares