UHPLC–MS/MS Analysis on Flavonoids Composition in <i>Astragalus membranaceus</i> and Their Antioxidant Activity

<i>Astragalus membranaceus</i> is a valuable medicinal plant species widely distributed in Asia. Its root is the main medicinal tissue rich in methoxylated flavonoids. Origin can highly influence the chemical composition and bioactivity. To characterize the principal chemicals influenced...

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Autores principales:	Zhili Sheng, Yueming Jiang, Junmei Liu, Bao Yang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antioxidant activity ORAC origin phenolics principal component analysis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d567f54497d544fa9b40addd8d27add0
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spelling	oai:doaj.org-article:d567f54497d544fa9b40addd8d27add02021-11-25T16:29:52ZUHPLC–MS/MS Analysis on Flavonoids Composition in <i>Astragalus membranaceus</i> and Their Antioxidant Activity10.3390/antiox101118522076-3921https://doaj.org/article/d567f54497d544fa9b40addd8d27add02021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1852https://doaj.org/toc/2076-3921<i>Astragalus membranaceus</i> is a valuable medicinal plant species widely distributed in Asia. Its root is the main medicinal tissue rich in methoxylated flavonoids. Origin can highly influence the chemical composition and bioactivity. To characterize the principal chemicals influenced by origin and provide more information about their antioxidant profile, the extracts of <i>A. membranaceus</i> roots from four origins were analysed by UHPLC-MS/MS. Thirty-four flavonoids, including thirteen methoxylated flavonoids, fifteen flavonoid glycosides and six flavonols, were identified. By principal component analysis, eighteen identified compounds were considered to be principal compounds. They could be used to differentiate <i>A. membranaceus</i> from Shanxi, Inner Mongolia, Heilongjiang and Gansu. The antioxidant activity was analysed by ORAC assay, DPPH radical scavenging activity assay and cell antioxidant activity assay. ‘Inner Mongolia’ extract showed the highest antioxidant activity. These results were helpful to understand how origin influenced the quality of <i>A. membranaceus</i>.Zhili ShengYueming JiangJunmei LiuBao YangMDPI AGarticleantioxidant activityORACoriginphenolicsprincipal component analysisTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1852, p 1852 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant activity ORAC origin phenolics principal component analysis Therapeutics. Pharmacology RM1-950
spellingShingle	antioxidant activity ORAC origin phenolics principal component analysis Therapeutics. Pharmacology RM1-950 Zhili Sheng Yueming Jiang Junmei Liu Bao Yang UHPLC–MS/MS Analysis on Flavonoids Composition in <i>Astragalus membranaceus</i> and Their Antioxidant Activity
description	<i>Astragalus membranaceus</i> is a valuable medicinal plant species widely distributed in Asia. Its root is the main medicinal tissue rich in methoxylated flavonoids. Origin can highly influence the chemical composition and bioactivity. To characterize the principal chemicals influenced by origin and provide more information about their antioxidant profile, the extracts of <i>A. membranaceus</i> roots from four origins were analysed by UHPLC-MS/MS. Thirty-four flavonoids, including thirteen methoxylated flavonoids, fifteen flavonoid glycosides and six flavonols, were identified. By principal component analysis, eighteen identified compounds were considered to be principal compounds. They could be used to differentiate <i>A. membranaceus</i> from Shanxi, Inner Mongolia, Heilongjiang and Gansu. The antioxidant activity was analysed by ORAC assay, DPPH radical scavenging activity assay and cell antioxidant activity assay. ‘Inner Mongolia’ extract showed the highest antioxidant activity. These results were helpful to understand how origin influenced the quality of <i>A. membranaceus</i>.
format	article
author	Zhili Sheng Yueming Jiang Junmei Liu Bao Yang
author_facet	Zhili Sheng Yueming Jiang Junmei Liu Bao Yang
author_sort	Zhili Sheng
title	UHPLC–MS/MS Analysis on Flavonoids Composition in <i>Astragalus membranaceus</i> and Their Antioxidant Activity
title_short	UHPLC–MS/MS Analysis on Flavonoids Composition in <i>Astragalus membranaceus</i> and Their Antioxidant Activity
title_full	UHPLC–MS/MS Analysis on Flavonoids Composition in <i>Astragalus membranaceus</i> and Their Antioxidant Activity
title_fullStr	UHPLC–MS/MS Analysis on Flavonoids Composition in <i>Astragalus membranaceus</i> and Their Antioxidant Activity
title_full_unstemmed	UHPLC–MS/MS Analysis on Flavonoids Composition in <i>Astragalus membranaceus</i> and Their Antioxidant Activity
title_sort	uhplc–ms/ms analysis on flavonoids composition in <i>astragalus membranaceus</i> and their antioxidant activity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d567f54497d544fa9b40addd8d27add0
work_keys_str_mv	AT zhilisheng uhplcmsmsanalysisonflavonoidscompositioniniastragalusmembranaceusiandtheirantioxidantactivity AT yuemingjiang uhplcmsmsanalysisonflavonoidscompositioniniastragalusmembranaceusiandtheirantioxidantactivity AT junmeiliu uhplcmsmsanalysisonflavonoidscompositioniniastragalusmembranaceusiandtheirantioxidantactivity AT baoyang uhplcmsmsanalysisonflavonoidscompositioniniastragalusmembranaceusiandtheirantioxidantactivity
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UHPLC–MS/MS Analysis on Flavonoids Composition in <i>Astragalus membranaceus</i> and Their Antioxidant Activity

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