Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest

Abstract Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we...

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Autores principales:	Joana Cabral, Diego Vidaurre, Paulo Marques, Ricardo Magalhães, Pedro Silva Moreira, José Miguel Soares, Gustavo Deco, Nuno Sousa, Morten L. Kringelbach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d56a3a99d6584585839dde85ce287554
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spelling	oai:doaj.org-article:d56a3a99d6584585839dde85ce2875542021-12-02T12:30:35ZCognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest10.1038/s41598-017-05425-72045-2322https://doaj.org/article/d56a3a99d6584585839dde85ce2875542017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05425-7https://doaj.org/toc/2045-2322Abstract Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment. We use a novel approach focusing on the dominant FC pattern captured by the leading eigenvector of dynamic FC matrices. Recurrent FC patterns – or states – are detected and characterized in terms of lifetime, probability of occurrence and switching profiles. We find that poorer cognitive performance is associated with weaker FC temporal similarity together with altered switching between FC states. These results provide new evidence linking the switching dynamics of FC during rest with cognitive performance in later life, reinforcing the functional role of resting-state activity for effective cognitive processing.Joana CabralDiego VidaurrePaulo MarquesRicardo MagalhãesPedro Silva MoreiraJosé Miguel SoaresGustavo DecoNuno SousaMorten L. KringelbachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joana Cabral Diego Vidaurre Paulo Marques Ricardo Magalhães Pedro Silva Moreira José Miguel Soares Gustavo Deco Nuno Sousa Morten L. Kringelbach Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest
description	Abstract Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment. We use a novel approach focusing on the dominant FC pattern captured by the leading eigenvector of dynamic FC matrices. Recurrent FC patterns – or states – are detected and characterized in terms of lifetime, probability of occurrence and switching profiles. We find that poorer cognitive performance is associated with weaker FC temporal similarity together with altered switching between FC states. These results provide new evidence linking the switching dynamics of FC during rest with cognitive performance in later life, reinforcing the functional role of resting-state activity for effective cognitive processing.
format	article
author	Joana Cabral Diego Vidaurre Paulo Marques Ricardo Magalhães Pedro Silva Moreira José Miguel Soares Gustavo Deco Nuno Sousa Morten L. Kringelbach
author_facet	Joana Cabral Diego Vidaurre Paulo Marques Ricardo Magalhães Pedro Silva Moreira José Miguel Soares Gustavo Deco Nuno Sousa Morten L. Kringelbach
author_sort	Joana Cabral
title	Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest
title_short	Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest
title_full	Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest
title_fullStr	Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest
title_full_unstemmed	Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest
title_sort	cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d56a3a99d6584585839dde85ce287554
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Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest

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