MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE

Autoimmune diseases and complications after transplantation operations are major public health problem, as they often lead to deterioration in the quality of life, reduce work capacity and disability in the population. To date, the induction of antigen-specific tolerance is the prom...

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Autores principales:	S. V. Sennikov, E. V. Kulikova, N. Yu. Knauer, Yu. N. Khantakova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	tolerogenic dendritic cells immunological tolerance central tolerance peripheral tolerance regulatory t cells regulatory b cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d57174c73bb94d1bb3d226a6325ba97f
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spelling	oai:doaj.org-article:d57174c73bb94d1bb3d226a6325ba97f2021-11-18T08:03:46ZMOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE1563-06252313-741X10.15789/1563-0625-2017-4-359-374https://doaj.org/article/d57174c73bb94d1bb3d226a6325ba97f2017-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1308https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAutoimmune diseases and complications after transplantation operations are major public health problem, as they often lead to deterioration in the quality of life, reduce work capacity and disability in the population. To date, the induction of antigen-specific tolerance is the promising method of therapy. During this process dendritic cells play important role. In this review current data of tolerogenic dendritic cells characterization, of factors inducing tolerogenic properties in dendritic cells, development of central and peripheral tolerance by dendritic cells, role of tolerogenic dendritic cells in the formation of regulatory B cells, molecular and cellular mechanisms that are involved in the formation of an immunological tolerance depending on tolerogenic dendritic cells were analyzed. Tolerogenic dendritic cells play a key role in maintaining of immune homeostasis by inducing immunological tolerance mechanisms which are associated with the generation of regulatory T cells, induction of anergy or apoptosis of T cells. Formation of tolerogenic properties in dendritic cells is occurred by various factors that regulate the maturation and differentiation of dendritic cells and induce anti-inflammatory agents synthesis of them. Because of their ability to induce natural and peripheral regulatory T cells, dendritic cells contribute to the development of the central and peripheral tolerance in the organism. Analysis of the results of experimental work demonstrates that in addition to induction of regulatory T cells tolerogenic dendritic cells participate in generating of regulatory B cells that play a role in the formation of tolerance and have the ability to affect the population of regulatory T cells. However, the mechanisms that lead to the formation of B cell population by tolerogenic dendritic cells have not been completely established yet. Review of published data showed that the molecular and cellular mechanisms of immunological tolerance induction by tolerogenic dendritic cells and other regulatory cell subpopulations interacting with each other are similar to a large extent. Currently, the role of tolerogenic dendritic cells in maintaining of immune tolerance is determined generally, however, some aspects require further investigation. Subsequent experimental studies will lead to a better understanding of the signaling mechanisms and the realization of immunological functions of tolerogenic dendritic cells, which provide additional information for application approaches development of tolerogenic dendritic cells for the control of autoimmune diseases and transplant complications.S. V. SennikovE. V. KulikovaN. Yu. KnauerYu. N. KhantakovaSPb RAACIarticletolerogenic dendritic cellsimmunological tolerancecentral toleranceperipheral toleranceregulatory t cellsregulatory b cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 4, Pp 359-374 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	tolerogenic dendritic cells immunological tolerance central tolerance peripheral tolerance regulatory t cells regulatory b cells Immunologic diseases. Allergy RC581-607
spellingShingle	tolerogenic dendritic cells immunological tolerance central tolerance peripheral tolerance regulatory t cells regulatory b cells Immunologic diseases. Allergy RC581-607 S. V. Sennikov E. V. Kulikova N. Yu. Knauer Yu. N. Khantakova MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE
description	Autoimmune diseases and complications after transplantation operations are major public health problem, as they often lead to deterioration in the quality of life, reduce work capacity and disability in the population. To date, the induction of antigen-specific tolerance is the promising method of therapy. During this process dendritic cells play important role. In this review current data of tolerogenic dendritic cells characterization, of factors inducing tolerogenic properties in dendritic cells, development of central and peripheral tolerance by dendritic cells, role of tolerogenic dendritic cells in the formation of regulatory B cells, molecular and cellular mechanisms that are involved in the formation of an immunological tolerance depending on tolerogenic dendritic cells were analyzed. Tolerogenic dendritic cells play a key role in maintaining of immune homeostasis by inducing immunological tolerance mechanisms which are associated with the generation of regulatory T cells, induction of anergy or apoptosis of T cells. Formation of tolerogenic properties in dendritic cells is occurred by various factors that regulate the maturation and differentiation of dendritic cells and induce anti-inflammatory agents synthesis of them. Because of their ability to induce natural and peripheral regulatory T cells, dendritic cells contribute to the development of the central and peripheral tolerance in the organism. Analysis of the results of experimental work demonstrates that in addition to induction of regulatory T cells tolerogenic dendritic cells participate in generating of regulatory B cells that play a role in the formation of tolerance and have the ability to affect the population of regulatory T cells. However, the mechanisms that lead to the formation of B cell population by tolerogenic dendritic cells have not been completely established yet. Review of published data showed that the molecular and cellular mechanisms of immunological tolerance induction by tolerogenic dendritic cells and other regulatory cell subpopulations interacting with each other are similar to a large extent. Currently, the role of tolerogenic dendritic cells in maintaining of immune tolerance is determined generally, however, some aspects require further investigation. Subsequent experimental studies will lead to a better understanding of the signaling mechanisms and the realization of immunological functions of tolerogenic dendritic cells, which provide additional information for application approaches development of tolerogenic dendritic cells for the control of autoimmune diseases and transplant complications.
format	article
author	S. V. Sennikov E. V. Kulikova N. Yu. Knauer Yu. N. Khantakova
author_facet	S. V. Sennikov E. V. Kulikova N. Yu. Knauer Yu. N. Khantakova
author_sort	S. V. Sennikov
title	MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE
title_short	MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE
title_full	MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE
title_fullStr	MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE
title_full_unstemmed	MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE
title_sort	molecular and cellular mechanisms mediated by dendritic cells involved in the induction of tolerance
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/d57174c73bb94d1bb3d226a6325ba97f
work_keys_str_mv	AT svsennikov molecularandcellularmechanismsmediatedbydendriticcellsinvolvedintheinductionoftolerance AT evkulikova molecularandcellularmechanismsmediatedbydendriticcellsinvolvedintheinductionoftolerance AT nyuknauer molecularandcellularmechanismsmediatedbydendriticcellsinvolvedintheinductionoftolerance AT yunkhantakova molecularandcellularmechanismsmediatedbydendriticcellsinvolvedintheinductionoftolerance
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MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE

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