Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.

<h4>Background</h4>Ethnically endogamous populations can shed light on the genetics of type 2 diabetes. Such studies are lacking in India. We conducted this study to determine the genetic and environmental contributions of anthropometric traits to type 2 diabetes risk in the Sindhi famil...

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Autores principales:	Manju Mamtani, Manisha T Jaisinghani, Sujeet G Jaiswal, Kanchan V Pipal, Ashwini A Patel, Hemant Kulkarni
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d57234af55474b6680f542812cee661a
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spelling	oai:doaj.org-article:d57234af55474b6680f542812cee661a2021-12-02T20:06:19ZGenetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.1932-620310.1371/journal.pone.0257390https://doaj.org/article/d57234af55474b6680f542812cee661a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257390https://doaj.org/toc/1932-6203<h4>Background</h4>Ethnically endogamous populations can shed light on the genetics of type 2 diabetes. Such studies are lacking in India. We conducted this study to determine the genetic and environmental contributions of anthropometric traits to type 2 diabetes risk in the Sindhi families in central India.<h4>Methods</h4>We conducted a family study in Indian Sindhi families with at least one case of type 2 diabetes. Variance components methods were used to quantify the genetic association of 18 anthropometric traits with eight type 2 diabetes related traits. Univariate and bivariate polygenic models were used to determine the heritability, genetic and environmental correlation of anthropometric traits with type 2 diabetes related traits.<h4>Results</h4>We included 1,152 individuals from 112 phenotyped families. The ascertainment-bias corrected prevalence of type 2 diabetes was 35%. Waist circumference, hip circumference and the biceps, triceps, subscapular and medial calf skinfold thicknesses were polygenically and significantly associated with type 2 diabetes. The range of heritability of the anthropometric traits and type 2 diabetes related traits was 0.27-0.73 and 0.00-0.39, respectively. Heritability of type 2 diabetes as a discrete trait was 0.35. Heritability curves demonstrated a substantial local influence of type 2 diabetes related traits. Bivariate trait analyses showed that biceps and abdominal skinfold thickness and all waist-containing indexes were strongly genetically correlated with type 2 diabetes.<h4>Conclusions</h4>In this first study of Sindhi families, we found evidence for genetic and environmental concordance of anthropometric traits with type 2 diabetes. Future studies need to probe into the genetics of type 2 diabetes in this population.Manju MamtaniManisha T JaisinghaniSujeet G JaiswalKanchan V PipalAshwini A PatelHemant KulkarniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257390 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manju Mamtani Manisha T Jaisinghani Sujeet G Jaiswal Kanchan V Pipal Ashwini A Patel Hemant Kulkarni Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.
description	<h4>Background</h4>Ethnically endogamous populations can shed light on the genetics of type 2 diabetes. Such studies are lacking in India. We conducted this study to determine the genetic and environmental contributions of anthropometric traits to type 2 diabetes risk in the Sindhi families in central India.<h4>Methods</h4>We conducted a family study in Indian Sindhi families with at least one case of type 2 diabetes. Variance components methods were used to quantify the genetic association of 18 anthropometric traits with eight type 2 diabetes related traits. Univariate and bivariate polygenic models were used to determine the heritability, genetic and environmental correlation of anthropometric traits with type 2 diabetes related traits.<h4>Results</h4>We included 1,152 individuals from 112 phenotyped families. The ascertainment-bias corrected prevalence of type 2 diabetes was 35%. Waist circumference, hip circumference and the biceps, triceps, subscapular and medial calf skinfold thicknesses were polygenically and significantly associated with type 2 diabetes. The range of heritability of the anthropometric traits and type 2 diabetes related traits was 0.27-0.73 and 0.00-0.39, respectively. Heritability of type 2 diabetes as a discrete trait was 0.35. Heritability curves demonstrated a substantial local influence of type 2 diabetes related traits. Bivariate trait analyses showed that biceps and abdominal skinfold thickness and all waist-containing indexes were strongly genetically correlated with type 2 diabetes.<h4>Conclusions</h4>In this first study of Sindhi families, we found evidence for genetic and environmental concordance of anthropometric traits with type 2 diabetes. Future studies need to probe into the genetics of type 2 diabetes in this population.
format	article
author	Manju Mamtani Manisha T Jaisinghani Sujeet G Jaiswal Kanchan V Pipal Ashwini A Patel Hemant Kulkarni
author_facet	Manju Mamtani Manisha T Jaisinghani Sujeet G Jaiswal Kanchan V Pipal Ashwini A Patel Hemant Kulkarni
author_sort	Manju Mamtani
title	Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.
title_short	Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.
title_full	Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.
title_fullStr	Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.
title_full_unstemmed	Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.
title_sort	genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous sindhi families.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d57234af55474b6680f542812cee661a
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Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.

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