Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision

Single molecule force measurements have shed light on dynamic biological events, but rare events escape notice owing to low throughput of the methods. Here, the authors combine an array of magnetic tweezers with lateral flow to increase throughput 100-fold, and detect rare DNA breaks induced by gyra...

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Main Authors:	Rohit Agarwal, Karl E. Duderstadt
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/d57278de37904fdbafba88ac63c97298
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spelling	oai:doaj.org-article:d57278de37904fdbafba88ac63c972982021-12-02T18:02:08ZMultiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision10.1038/s41467-020-18456-y2041-1723https://doaj.org/article/d57278de37904fdbafba88ac63c972982020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18456-yhttps://doaj.org/toc/2041-1723Single molecule force measurements have shed light on dynamic biological events, but rare events escape notice owing to low throughput of the methods. Here, the authors combine an array of magnetic tweezers with lateral flow to increase throughput 100-fold, and detect rare DNA breaks induced by gyrase.Rohit AgarwalKarl E. DuderstadtNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rohit Agarwal Karl E. Duderstadt Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision
description	Single molecule force measurements have shed light on dynamic biological events, but rare events escape notice owing to low throughput of the methods. Here, the authors combine an array of magnetic tweezers with lateral flow to increase throughput 100-fold, and detect rare DNA breaks induced by gyrase.
format	article
author	Rohit Agarwal Karl E. Duderstadt
author_facet	Rohit Agarwal Karl E. Duderstadt
author_sort	Rohit Agarwal
title	Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision
title_short	Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision
title_full	Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision
title_fullStr	Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision
title_full_unstemmed	Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision
title_sort	multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d57278de37904fdbafba88ac63c97298
work_keys_str_mv	AT rohitagarwal multiplexflowmagnetictweezersrevealrareenzymaticeventswithsinglemoleculeprecision AT karleduderstadt multiplexflowmagnetictweezersrevealrareenzymaticeventswithsinglemoleculeprecision
_version_	1718378957289553920

Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision

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