Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties

It has been proposed recently that major depressive disorder (MDD) could represent an adaptation to conserve energy after the perceived loss of an investment in a vital source, such as group identity, personal assets, or relationships. Energy conserving behaviors associated with MDD may form a persi...

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Autores principales:	Ge Xiong, Daifeng Dong, Chang Cheng, Yali Jiang, Xiaoqiang Sun, Jiayue He, Chuting Li, Yidian Gao, Xue Zhong, Haofei Zhao, Xiang Wang, Shuqiao Yao
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Major depressive disorder Remitted depression Subcortical volume Structural covariance network State-independent alteration Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d576f7fd064345039d0ae9d3a5b4fbf8
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spelling	oai:doaj.org-article:d576f7fd064345039d0ae9d3a5b4fbf82021-11-06T04:27:59ZPotential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties2213-158210.1016/j.nicl.2021.102871https://doaj.org/article/d576f7fd064345039d0ae9d3a5b4fbf82021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003156https://doaj.org/toc/2213-1582It has been proposed recently that major depressive disorder (MDD) could represent an adaptation to conserve energy after the perceived loss of an investment in a vital source, such as group identity, personal assets, or relationships. Energy conserving behaviors associated with MDD may form a persistent marker in brain regions and networks involved in cognition and emotion regulation. In this study, we examined whether subcortical regions and volume-based structural covariance networks (SCNs) have state-independent alterations (trait markers).First-episode drug-naïve currently depressed (cMDD) patients (N = 131), remitted MDD (RD) patients (N = 67), and healthy controls (HCs, N = 235) underwent structural magnetic resonance imaging (MRI). Subcortical gray matter volumes (GMVs) were calculated in FreeSurfer software, and group differences in GMVs and SCN were analyzed.Compared to HCs, major findings were decreased GMVs of left pallidum and pulvinar anterior of thalamus in the cMDD and RD groups, indicative of a trait marker. Relative to HCs, subcortical SCNs of both cMDD and RD patients were found to have reduced small-world-ness and path length, which together may represent a trait-like topological feature of depression.In sum, the left pallidum, left pulvinar anterior of thalamus volumetric alterations may represent trait marker and reduced small-world-ness, path length may represent trait-like topological feature of MDD.Ge XiongDaifeng DongChang ChengYali JiangXiaoqiang SunJiayue HeChuting LiYidian GaoXue ZhongHaofei ZhaoXiang WangShuqiao YaoElsevierarticleMajor depressive disorderRemitted depressionSubcortical volumeStructural covariance networkState-independent alterationComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102871- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Major depressive disorder Remitted depression Subcortical volume Structural covariance network State-independent alteration Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Major depressive disorder Remitted depression Subcortical volume Structural covariance network State-independent alteration Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Ge Xiong Daifeng Dong Chang Cheng Yali Jiang Xiaoqiang Sun Jiayue He Chuting Li Yidian Gao Xue Zhong Haofei Zhao Xiang Wang Shuqiao Yao Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties
description	It has been proposed recently that major depressive disorder (MDD) could represent an adaptation to conserve energy after the perceived loss of an investment in a vital source, such as group identity, personal assets, or relationships. Energy conserving behaviors associated with MDD may form a persistent marker in brain regions and networks involved in cognition and emotion regulation. In this study, we examined whether subcortical regions and volume-based structural covariance networks (SCNs) have state-independent alterations (trait markers).First-episode drug-naïve currently depressed (cMDD) patients (N = 131), remitted MDD (RD) patients (N = 67), and healthy controls (HCs, N = 235) underwent structural magnetic resonance imaging (MRI). Subcortical gray matter volumes (GMVs) were calculated in FreeSurfer software, and group differences in GMVs and SCN were analyzed.Compared to HCs, major findings were decreased GMVs of left pallidum and pulvinar anterior of thalamus in the cMDD and RD groups, indicative of a trait marker. Relative to HCs, subcortical SCNs of both cMDD and RD patients were found to have reduced small-world-ness and path length, which together may represent a trait-like topological feature of depression.In sum, the left pallidum, left pulvinar anterior of thalamus volumetric alterations may represent trait marker and reduced small-world-ness, path length may represent trait-like topological feature of MDD.
format	article
author	Ge Xiong Daifeng Dong Chang Cheng Yali Jiang Xiaoqiang Sun Jiayue He Chuting Li Yidian Gao Xue Zhong Haofei Zhao Xiang Wang Shuqiao Yao
author_facet	Ge Xiong Daifeng Dong Chang Cheng Yali Jiang Xiaoqiang Sun Jiayue He Chuting Li Yidian Gao Xue Zhong Haofei Zhao Xiang Wang Shuqiao Yao
author_sort	Ge Xiong
title	Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties
title_short	Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties
title_full	Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties
title_fullStr	Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties
title_full_unstemmed	Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties
title_sort	potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d576f7fd064345039d0ae9d3a5b4fbf8
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Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties

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