Microdialysis and microperfusion electrodes in neurologic disease monitoring

Abstract Contemporary biomarker collection techniques in blood and cerebrospinal fluid have to date offered only modest clinical insights into neurologic diseases such as epilepsy and glioma. Conversely, the collection of human electroencephalography (EEG) data has long been the standard of care in...

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Autores principales:	Luke A. Stangler, Abbas Kouzani, Kevin E. Bennet, Ludovic Dumee, Michael Berk, Gregory A. Worrell, Steven Steele, Terence C. Burns, Charles L. Howe
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d578ea0139c443eea743608ea0f77802
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spelling	oai:doaj.org-article:d578ea0139c443eea743608ea0f778022021-12-05T12:04:32ZMicrodialysis and microperfusion electrodes in neurologic disease monitoring10.1186/s12987-021-00292-x2045-8118https://doaj.org/article/d578ea0139c443eea743608ea0f778022021-12-01T00:00:00Zhttps://doi.org/10.1186/s12987-021-00292-xhttps://doaj.org/toc/2045-8118Abstract Contemporary biomarker collection techniques in blood and cerebrospinal fluid have to date offered only modest clinical insights into neurologic diseases such as epilepsy and glioma. Conversely, the collection of human electroencephalography (EEG) data has long been the standard of care in these patients, enabling individualized insights for therapy and revealing fundamental principles of human neurophysiology. Increasing interest exists in simultaneously measuring neurochemical biomarkers and electrophysiological data to enhance our understanding of human disease mechanisms. This review compares microdialysis, microperfusion, and implanted EEG probe architectures and performance parameters. Invasive consequences of probe implantation are also investigated along with the functional impact of biofouling. Finally, previously developed microdialysis electrodes and microperfusion electrodes are reviewed in preclinical and clinical settings. Critically, current and precedent microdialysis and microperfusion probes lack the ability to collect neurochemical data that is spatially and temporally coincident with EEG data derived from depth electrodes. This ultimately limits diagnostic and therapeutic progress in epilepsy and glioma research. However, this gap also provides a unique opportunity to create a dual-sensing technology that will provide unprecedented insights into the pathogenic mechanisms of human neurologic disease.Luke A. StanglerAbbas KouzaniKevin E. BennetLudovic DumeeMichael BerkGregory A. WorrellSteven SteeleTerence C. BurnsCharles L. HoweBMCarticleNeurology. Diseases of the nervous systemRC346-429ENFluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Luke A. Stangler Abbas Kouzani Kevin E. Bennet Ludovic Dumee Michael Berk Gregory A. Worrell Steven Steele Terence C. Burns Charles L. Howe Microdialysis and microperfusion electrodes in neurologic disease monitoring
description	Abstract Contemporary biomarker collection techniques in blood and cerebrospinal fluid have to date offered only modest clinical insights into neurologic diseases such as epilepsy and glioma. Conversely, the collection of human electroencephalography (EEG) data has long been the standard of care in these patients, enabling individualized insights for therapy and revealing fundamental principles of human neurophysiology. Increasing interest exists in simultaneously measuring neurochemical biomarkers and electrophysiological data to enhance our understanding of human disease mechanisms. This review compares microdialysis, microperfusion, and implanted EEG probe architectures and performance parameters. Invasive consequences of probe implantation are also investigated along with the functional impact of biofouling. Finally, previously developed microdialysis electrodes and microperfusion electrodes are reviewed in preclinical and clinical settings. Critically, current and precedent microdialysis and microperfusion probes lack the ability to collect neurochemical data that is spatially and temporally coincident with EEG data derived from depth electrodes. This ultimately limits diagnostic and therapeutic progress in epilepsy and glioma research. However, this gap also provides a unique opportunity to create a dual-sensing technology that will provide unprecedented insights into the pathogenic mechanisms of human neurologic disease.
format	article
author	Luke A. Stangler Abbas Kouzani Kevin E. Bennet Ludovic Dumee Michael Berk Gregory A. Worrell Steven Steele Terence C. Burns Charles L. Howe
author_facet	Luke A. Stangler Abbas Kouzani Kevin E. Bennet Ludovic Dumee Michael Berk Gregory A. Worrell Steven Steele Terence C. Burns Charles L. Howe
author_sort	Luke A. Stangler
title	Microdialysis and microperfusion electrodes in neurologic disease monitoring
title_short	Microdialysis and microperfusion electrodes in neurologic disease monitoring
title_full	Microdialysis and microperfusion electrodes in neurologic disease monitoring
title_fullStr	Microdialysis and microperfusion electrodes in neurologic disease monitoring
title_full_unstemmed	Microdialysis and microperfusion electrodes in neurologic disease monitoring
title_sort	microdialysis and microperfusion electrodes in neurologic disease monitoring
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d578ea0139c443eea743608ea0f77802
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Microdialysis and microperfusion electrodes in neurologic disease monitoring

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