The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

The circadian clock can affect pathogen replication, but underlying molecular mechanisms are unclear. Here the authors demonstrate that the circadian components BMAL1 and REV-ERBα affect entry of hepatitis C virus (HCV) into hepatocytes and genome replication of HCV and related flaviviruses dengue a...

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Autores principales: Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Jane A. McKeating
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/d57b7a19acc942b6a61940c29a11b307
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spelling oai:doaj.org-article:d57b7a19acc942b6a61940c29a11b3072021-12-02T17:02:18ZThe circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication10.1038/s41467-019-08299-72041-1723https://doaj.org/article/d57b7a19acc942b6a61940c29a11b3072019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08299-7https://doaj.org/toc/2041-1723The circadian clock can affect pathogen replication, but underlying molecular mechanisms are unclear. Here the authors demonstrate that the circadian components BMAL1 and REV-ERBα affect entry of hepatitis C virus (HCV) into hepatocytes and genome replication of HCV and related flaviviruses dengue and zika.Xiaodong ZhuangAndrea MagriMichelle HillAlvina G. LaiAbhinav KumarSrinivasa Bhargav RambhatlaClaire L. DonaldAndrea F. Lopez-ClavijoSimon RudgeKatherine PinnickWai Hoong ChangPeter A. C. WingRyan BrownXiming QinPeter SimmondsThomas F. BaumertDavid RayAndrew LoudonPeter BalfeMichael WakelamSam ButterworthAlain KohlCatherine L. JoplingNicole ZitzmannJane A. McKeatingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaodong Zhuang
Andrea Magri
Michelle Hill
Alvina G. Lai
Abhinav Kumar
Srinivasa Bhargav Rambhatla
Claire L. Donald
Andrea F. Lopez-Clavijo
Simon Rudge
Katherine Pinnick
Wai Hoong Chang
Peter A. C. Wing
Ryan Brown
Ximing Qin
Peter Simmonds
Thomas F. Baumert
David Ray
Andrew Loudon
Peter Balfe
Michael Wakelam
Sam Butterworth
Alain Kohl
Catherine L. Jopling
Nicole Zitzmann
Jane A. McKeating
The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
description The circadian clock can affect pathogen replication, but underlying molecular mechanisms are unclear. Here the authors demonstrate that the circadian components BMAL1 and REV-ERBα affect entry of hepatitis C virus (HCV) into hepatocytes and genome replication of HCV and related flaviviruses dengue and zika.
format article
author Xiaodong Zhuang
Andrea Magri
Michelle Hill
Alvina G. Lai
Abhinav Kumar
Srinivasa Bhargav Rambhatla
Claire L. Donald
Andrea F. Lopez-Clavijo
Simon Rudge
Katherine Pinnick
Wai Hoong Chang
Peter A. C. Wing
Ryan Brown
Ximing Qin
Peter Simmonds
Thomas F. Baumert
David Ray
Andrew Loudon
Peter Balfe
Michael Wakelam
Sam Butterworth
Alain Kohl
Catherine L. Jopling
Nicole Zitzmann
Jane A. McKeating
author_facet Xiaodong Zhuang
Andrea Magri
Michelle Hill
Alvina G. Lai
Abhinav Kumar
Srinivasa Bhargav Rambhatla
Claire L. Donald
Andrea F. Lopez-Clavijo
Simon Rudge
Katherine Pinnick
Wai Hoong Chang
Peter A. C. Wing
Ryan Brown
Ximing Qin
Peter Simmonds
Thomas F. Baumert
David Ray
Andrew Loudon
Peter Balfe
Michael Wakelam
Sam Butterworth
Alain Kohl
Catherine L. Jopling
Nicole Zitzmann
Jane A. McKeating
author_sort Xiaodong Zhuang
title The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
title_short The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
title_full The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
title_fullStr The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
title_full_unstemmed The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
title_sort circadian clock components bmal1 and rev-erbα regulate flavivirus replication
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/d57b7a19acc942b6a61940c29a11b307
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