MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modulation of the AKT/mTOR pathway.

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Detalles Bibliográficos
Autores principales: Michal Smida, Ferran Fece de la Cruz, Claudia Kerzendorfer, Iris Z. Uras, Barbara Mair, Abdelghani Mazouzi, Tereza Suchankova, Tomasz Konopka, Amanda M. Katz, Keren Paz, Katalin Nagy-Bojarszky, Markus K. Muellner, Zsuzsanna Bago-Horvath, Eric B. Haura, Joanna I. Loizou, Sebastian M. B. Nijman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d580c8bada764855b9d9cdb7d5d53e6b
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Descripción
Sumario:ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modulation of the AKT/mTOR pathway.

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