MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modulation of the AKT/mTOR pathway.

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Autores principales:	Michal Smida, Ferran Fece de la Cruz, Claudia Kerzendorfer, Iris Z. Uras, Barbara Mair, Abdelghani Mazouzi, Tereza Suchankova, Tomasz Konopka, Amanda M. Katz, Keren Paz, Katalin Nagy-Bojarszky, Markus K. Muellner, Zsuzsanna Bago-Horvath, Eric B. Haura, Joanna I. Loizou, Sebastian M. B. Nijman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d580c8bada764855b9d9cdb7d5d53e6b
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spelling	oai:doaj.org-article:d580c8bada764855b9d9cdb7d5d53e6b2021-12-02T14:39:50ZMEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated10.1038/ncomms137012041-1723https://doaj.org/article/d580c8bada764855b9d9cdb7d5d53e6b2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13701https://doaj.org/toc/2041-1723ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modulation of the AKT/mTOR pathway.Michal SmidaFerran Fece de la CruzClaudia KerzendorferIris Z. UrasBarbara MairAbdelghani MazouziTereza SuchankovaTomasz KonopkaAmanda M. KatzKeren PazKatalin Nagy-BojarszkyMarkus K. MuellnerZsuzsanna Bago-HorvathEric B. HauraJoanna I. LoizouSebastian M. B. NijmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michal Smida Ferran Fece de la Cruz Claudia Kerzendorfer Iris Z. Uras Barbara Mair Abdelghani Mazouzi Tereza Suchankova Tomasz Konopka Amanda M. Katz Keren Paz Katalin Nagy-Bojarszky Markus K. Muellner Zsuzsanna Bago-Horvath Eric B. Haura Joanna I. Loizou Sebastian M. B. Nijman MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated
description	ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modulation of the AKT/mTOR pathway.
format	article
author	Michal Smida Ferran Fece de la Cruz Claudia Kerzendorfer Iris Z. Uras Barbara Mair Abdelghani Mazouzi Tereza Suchankova Tomasz Konopka Amanda M. Katz Keren Paz Katalin Nagy-Bojarszky Markus K. Muellner Zsuzsanna Bago-Horvath Eric B. Haura Joanna I. Loizou Sebastian M. B. Nijman
author_facet	Michal Smida Ferran Fece de la Cruz Claudia Kerzendorfer Iris Z. Uras Barbara Mair Abdelghani Mazouzi Tereza Suchankova Tomasz Konopka Amanda M. Katz Keren Paz Katalin Nagy-Bojarszky Markus K. Muellner Zsuzsanna Bago-Horvath Eric B. Haura Joanna I. Loizou Sebastian M. B. Nijman
author_sort	Michal Smida
title	MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated
title_short	MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated
title_full	MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated
title_fullStr	MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated
title_full_unstemmed	MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated
title_sort	mek inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d580c8bada764855b9d9cdb7d5d53e6b
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MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

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