The association between depression and esophageal cancer in China: a multicentre population-based study

Abstract Background Esophageal cancer (EC) is one of the leading contributors to the global burden of cancer, and the underlying mechanism is still unknown. Recently, there has been a growing interest in understanding modifiable psychosocial risk factors, particularly depression, to prevent EC and r...

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Autores principales:	Juan Zhu, Shanrui Ma, Yueyue Zhou, Ru Chen, Shuanghua Xie, Zhengkui Liu, Xinqing Li, Wenqiang Wei
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Esophageal cancer Depression PHQ-9 Endoscopy High-risk regions Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/d58360473e824128915bffb2c3b3fdf7
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spelling	oai:doaj.org-article:d58360473e824128915bffb2c3b3fdf72021-11-14T12:08:34ZThe association between depression and esophageal cancer in China: a multicentre population-based study10.1186/s12888-021-03534-21471-244Xhttps://doaj.org/article/d58360473e824128915bffb2c3b3fdf72021-11-01T00:00:00Zhttps://doi.org/10.1186/s12888-021-03534-2https://doaj.org/toc/1471-244XAbstract Background Esophageal cancer (EC) is one of the leading contributors to the global burden of cancer, and the underlying mechanism is still unknown. Recently, there has been a growing interest in understanding modifiable psychosocial risk factors, particularly depression, to prevent EC and reduce morbidity and mortality. However, related research is sparse and has been ignored. The study was designed to assess the association between depression and EC in China. Methods From 2017 to 2019, a population-based multicenter study was conducted in high-risk regions of EC. Participants underwent a free endoscopy screening. If the endoscopic results were suspicious, a pathological biopsy was applied to confirm. Depression was measured with Patient Health Questionnaire-9 (PHQ-9). In addition, information on demographic characteristics and risk factors was collected from participants by trained interviewers using uniform questionnaires. Results After Endoscopy and pathologic diagnosis, 15,936 participants in high-risk regions of EC (ECHRRs) were enrolled, 10,907 (68.44%) of which were diagnosed health, 4048 (25.40%) with esophagitis, 769 (4.83%) with low-grade intraepithelial neoplasia (LGIN), 157 (0.99%) with high-grade intraepithelial neoplasia (HGIN), and 55 (0.35%) with EC, respectively. The overall prevalence of depression symptoms of participants was 4.16% (health: 4.63%, esophagitis: 2.99%, LGIN: 2.99%, HGIN: 5.73%, and EC: 9.09%). Multiple logistic regression analyses revealed that the unadjusted OR (95% CI) between depression and each esophageal pathology grades were esophagitis 0.93 (0.92-0.95), LGIN 0.97 (0.94-0.99), HGIN 1.05 (1.00-1.10), and EC 1.04 (0.97-1.14), respectively. However, after adjustment for potential confounders (age, gender, region, alcohol consumption, BMI), no statistically significant associations between depression and EC (adjusted OR = 1.10, 0.99-1.21) and esophageal lesions (esophagitis: adjusted OR = 1.02, 0.99-1.04; LGIN: adjusted OR = 0.98, 0.95-1.01; HGIN: adjusted OR = 1.04, 0.98-1.11) were observed in this study. Conclusions No significant association was observed between depression and EC in the study. Future prospective cohort studies are needed to verify this preliminary finding.Juan ZhuShanrui MaYueyue ZhouRu ChenShuanghua XieZhengkui LiuXinqing LiWenqiang WeiBMCarticleEsophageal cancerDepressionPHQ-9EndoscopyHigh-risk regionsPsychiatryRC435-571ENBMC Psychiatry, Vol 21, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Esophageal cancer Depression PHQ-9 Endoscopy High-risk regions Psychiatry RC435-571
spellingShingle	Esophageal cancer Depression PHQ-9 Endoscopy High-risk regions Psychiatry RC435-571 Juan Zhu Shanrui Ma Yueyue Zhou Ru Chen Shuanghua Xie Zhengkui Liu Xinqing Li Wenqiang Wei The association between depression and esophageal cancer in China: a multicentre population-based study
description	Abstract Background Esophageal cancer (EC) is one of the leading contributors to the global burden of cancer, and the underlying mechanism is still unknown. Recently, there has been a growing interest in understanding modifiable psychosocial risk factors, particularly depression, to prevent EC and reduce morbidity and mortality. However, related research is sparse and has been ignored. The study was designed to assess the association between depression and EC in China. Methods From 2017 to 2019, a population-based multicenter study was conducted in high-risk regions of EC. Participants underwent a free endoscopy screening. If the endoscopic results were suspicious, a pathological biopsy was applied to confirm. Depression was measured with Patient Health Questionnaire-9 (PHQ-9). In addition, information on demographic characteristics and risk factors was collected from participants by trained interviewers using uniform questionnaires. Results After Endoscopy and pathologic diagnosis, 15,936 participants in high-risk regions of EC (ECHRRs) were enrolled, 10,907 (68.44%) of which were diagnosed health, 4048 (25.40%) with esophagitis, 769 (4.83%) with low-grade intraepithelial neoplasia (LGIN), 157 (0.99%) with high-grade intraepithelial neoplasia (HGIN), and 55 (0.35%) with EC, respectively. The overall prevalence of depression symptoms of participants was 4.16% (health: 4.63%, esophagitis: 2.99%, LGIN: 2.99%, HGIN: 5.73%, and EC: 9.09%). Multiple logistic regression analyses revealed that the unadjusted OR (95% CI) between depression and each esophageal pathology grades were esophagitis 0.93 (0.92-0.95), LGIN 0.97 (0.94-0.99), HGIN 1.05 (1.00-1.10), and EC 1.04 (0.97-1.14), respectively. However, after adjustment for potential confounders (age, gender, region, alcohol consumption, BMI), no statistically significant associations between depression and EC (adjusted OR = 1.10, 0.99-1.21) and esophageal lesions (esophagitis: adjusted OR = 1.02, 0.99-1.04; LGIN: adjusted OR = 0.98, 0.95-1.01; HGIN: adjusted OR = 1.04, 0.98-1.11) were observed in this study. Conclusions No significant association was observed between depression and EC in the study. Future prospective cohort studies are needed to verify this preliminary finding.
format	article
author	Juan Zhu Shanrui Ma Yueyue Zhou Ru Chen Shuanghua Xie Zhengkui Liu Xinqing Li Wenqiang Wei
author_facet	Juan Zhu Shanrui Ma Yueyue Zhou Ru Chen Shuanghua Xie Zhengkui Liu Xinqing Li Wenqiang Wei
author_sort	Juan Zhu
title	The association between depression and esophageal cancer in China: a multicentre population-based study
title_short	The association between depression and esophageal cancer in China: a multicentre population-based study
title_full	The association between depression and esophageal cancer in China: a multicentre population-based study
title_fullStr	The association between depression and esophageal cancer in China: a multicentre population-based study
title_full_unstemmed	The association between depression and esophageal cancer in China: a multicentre population-based study
title_sort	association between depression and esophageal cancer in china: a multicentre population-based study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d58360473e824128915bffb2c3b3fdf7
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The association between depression and esophageal cancer in China: a multicentre population-based study

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