Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess

Abstract Nonclassic apparent mineralocorticoid excess (NC-AME) is proposed as a novel clinical condition with a mild phenotypic spectrum that ranges from normotension to severe hypertension. This condition is mainly characterized by a high serum cortisol to cortisone ratio (F/E) and concomitant low...

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Autores principales:	Alejandra Tapia-Castillo, Cristian A. Carvajal, Xaviera López-Cortés, Andrea Vecchiola, Carlos E. Fardella
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d585c5602e864731b30d1b58ec5cb65e
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spelling	oai:doaj.org-article:d585c5602e864731b30d1b58ec5cb65e2021-12-02T19:02:35ZNovel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess10.1038/s41598-021-96628-62045-2322https://doaj.org/article/d585c5602e864731b30d1b58ec5cb65e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96628-6https://doaj.org/toc/2045-2322Abstract Nonclassic apparent mineralocorticoid excess (NC-AME) is proposed as a novel clinical condition with a mild phenotypic spectrum that ranges from normotension to severe hypertension. This condition is mainly characterized by a high serum cortisol to cortisone ratio (F/E) and concomitant low cortisone (E), however further metabolic changes in NC-AME have not been studied. A cross-sectional study was performed in a primary-care cohort of 396 Chilean subjects, which were classified in two groups: NC-AME (n = 28) and healthy controls (n = 27). A discovery study based in untargeted metabolomics assay in serum samples from both groups was performed by UPLC-Q-TOF/MS. Global metabolomic variations were assayed by principal component analysis and further compared by orthogonal partial least-squares discriminant analysis (OPLS-DA). NC-AME subjects exhibited higher values of blood pressure, fractional excretion of potassium, and lower plasma renin activity and urinary sodium to potassium ratio. Metabolomic analyses showed 36 differentially regulated metabolites between NC-AME and control subjects. A ROC curve analyses identified eight metabolites with high discriminatory capacity between NC-AME and control subjects. Moreover, gamma-l-glutamyl-l-methionine sulfoxide and 5-sulfoxymethylfurfural, exhibited significant association with cortisone, which are potential biomarkers of NC-AME, however further assays should elucidate its biological role in setup and progression of this phenotype.Alejandra Tapia-CastilloCristian A. CarvajalXaviera López-CortésAndrea VecchiolaCarlos E. FardellaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alejandra Tapia-Castillo Cristian A. Carvajal Xaviera López-Cortés Andrea Vecchiola Carlos E. Fardella Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess
description	Abstract Nonclassic apparent mineralocorticoid excess (NC-AME) is proposed as a novel clinical condition with a mild phenotypic spectrum that ranges from normotension to severe hypertension. This condition is mainly characterized by a high serum cortisol to cortisone ratio (F/E) and concomitant low cortisone (E), however further metabolic changes in NC-AME have not been studied. A cross-sectional study was performed in a primary-care cohort of 396 Chilean subjects, which were classified in two groups: NC-AME (n = 28) and healthy controls (n = 27). A discovery study based in untargeted metabolomics assay in serum samples from both groups was performed by UPLC-Q-TOF/MS. Global metabolomic variations were assayed by principal component analysis and further compared by orthogonal partial least-squares discriminant analysis (OPLS-DA). NC-AME subjects exhibited higher values of blood pressure, fractional excretion of potassium, and lower plasma renin activity and urinary sodium to potassium ratio. Metabolomic analyses showed 36 differentially regulated metabolites between NC-AME and control subjects. A ROC curve analyses identified eight metabolites with high discriminatory capacity between NC-AME and control subjects. Moreover, gamma-l-glutamyl-l-methionine sulfoxide and 5-sulfoxymethylfurfural, exhibited significant association with cortisone, which are potential biomarkers of NC-AME, however further assays should elucidate its biological role in setup and progression of this phenotype.
format	article
author	Alejandra Tapia-Castillo Cristian A. Carvajal Xaviera López-Cortés Andrea Vecchiola Carlos E. Fardella
author_facet	Alejandra Tapia-Castillo Cristian A. Carvajal Xaviera López-Cortés Andrea Vecchiola Carlos E. Fardella
author_sort	Alejandra Tapia-Castillo
title	Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess
title_short	Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess
title_full	Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess
title_fullStr	Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess
title_full_unstemmed	Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess
title_sort	novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d585c5602e864731b30d1b58ec5cb65e
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Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess

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