Theranostic applications of nanoparticles in neurodegenerative disorders

Sahana Ramanathan,1 Govindaraju Archunan,2 Muthusamy Sivakumar,3 Subramanian Tamil Selvan,4 A Lenin Fred,5 Sundramurthy Kumar,1 Balázs Gulyás,1 Parasuraman Padmanabhan1 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; 2Department of Animal Scien...

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Autores principales:	Ramanathan S, Archunan G, Sivakumar M, Tamil Selvan S, Fred AL, Kumar S, Gulyás B, Padmanabhan P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	theranostics neurological disease nanoparticles imaging. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d58b611fa3c841aa9714f942805c6f7c
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spelling	oai:doaj.org-article:d58b611fa3c841aa9714f942805c6f7c2021-12-02T03:22:57ZTheranostic applications of nanoparticles in neurodegenerative disorders1178-2013https://doaj.org/article/d58b611fa3c841aa9714f942805c6f7c2018-09-01T00:00:00Zhttps://www.dovepress.com/theranostic-applications-of-nanoparticles-in-neurodegenerative-disorde-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sahana Ramanathan,1 Govindaraju Archunan,2 Muthusamy Sivakumar,3 Subramanian Tamil Selvan,4 A Lenin Fred,5 Sundramurthy Kumar,1 Balázs Gulyás,1 Parasuraman Padmanabhan1 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; 2Department of Animal Science, Centre for Pheromone Technology (CPT), Bharathidasan University, Tiruchirappalli, India; 3Nanoscience and Technology, Anna University – BIT Campus, Tiruchirappalli, India; 4Institute of Materials Research and Engineering, Singapore; 5Mar Ephraem College of Engineering and Technology, Kanyakumari, India Abstract: The preeminent treatments for neurodegenerative disease are often unavailable due to the poor accessibility of therapeutic drugs. Moreover, the blood–brain barrier (BBB) effectively blocks the transfer of cells, particles and large molecules, ie, drugs, across the brain. The most important challenge in the treatment of neurodegenerative diseases is the development of targeted drug delivery system. Theranostic strategies are known to combine therapeutic and diagnostic capabilities together. The aim of this review was to record the response to treatment and thereby improve drug safety. Nanotechnology offers a platform for designing and developing theranostic agents that can be used as an efficient nano-carrier system. This is achieved by the manipulation of some of the properties of nanoparticles (NPs), thereby enabling the attachment of suitable drugs onto their surface. The results provide revolutionary treatments by stimulation and thus interaction with targeted sites to promote physiological response with minimum side effects. This review is a brief discussion of the administration of drugs across the brain and the advantages of using NPs as an effective theranostic platform in the treatment of Alzheimer’s, Parkinson’s, epilepsy and Huntington’s disease. Keywords: theranostics, neurological disease, nanoparticles, imagingRamanathan SArchunan GSivakumar MTamil Selvan SFred ALKumar SGulyás BPadmanabhan PDove Medical Pressarticletheranosticsneurological diseasenanoparticlesimaging.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5561-5576 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	theranostics neurological disease nanoparticles imaging. Medicine (General) R5-920
spellingShingle	theranostics neurological disease nanoparticles imaging. Medicine (General) R5-920 Ramanathan S Archunan G Sivakumar M Tamil Selvan S Fred AL Kumar S Gulyás B Padmanabhan P Theranostic applications of nanoparticles in neurodegenerative disorders
description	Sahana Ramanathan,1 Govindaraju Archunan,2 Muthusamy Sivakumar,3 Subramanian Tamil Selvan,4 A Lenin Fred,5 Sundramurthy Kumar,1 Balázs Gulyás,1 Parasuraman Padmanabhan1 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; 2Department of Animal Science, Centre for Pheromone Technology (CPT), Bharathidasan University, Tiruchirappalli, India; 3Nanoscience and Technology, Anna University – BIT Campus, Tiruchirappalli, India; 4Institute of Materials Research and Engineering, Singapore; 5Mar Ephraem College of Engineering and Technology, Kanyakumari, India Abstract: The preeminent treatments for neurodegenerative disease are often unavailable due to the poor accessibility of therapeutic drugs. Moreover, the blood–brain barrier (BBB) effectively blocks the transfer of cells, particles and large molecules, ie, drugs, across the brain. The most important challenge in the treatment of neurodegenerative diseases is the development of targeted drug delivery system. Theranostic strategies are known to combine therapeutic and diagnostic capabilities together. The aim of this review was to record the response to treatment and thereby improve drug safety. Nanotechnology offers a platform for designing and developing theranostic agents that can be used as an efficient nano-carrier system. This is achieved by the manipulation of some of the properties of nanoparticles (NPs), thereby enabling the attachment of suitable drugs onto their surface. The results provide revolutionary treatments by stimulation and thus interaction with targeted sites to promote physiological response with minimum side effects. This review is a brief discussion of the administration of drugs across the brain and the advantages of using NPs as an effective theranostic platform in the treatment of Alzheimer’s, Parkinson’s, epilepsy and Huntington’s disease. Keywords: theranostics, neurological disease, nanoparticles, imaging
format	article
author	Ramanathan S Archunan G Sivakumar M Tamil Selvan S Fred AL Kumar S Gulyás B Padmanabhan P
author_facet	Ramanathan S Archunan G Sivakumar M Tamil Selvan S Fred AL Kumar S Gulyás B Padmanabhan P
author_sort	Ramanathan S
title	Theranostic applications of nanoparticles in neurodegenerative disorders
title_short	Theranostic applications of nanoparticles in neurodegenerative disorders
title_full	Theranostic applications of nanoparticles in neurodegenerative disorders
title_fullStr	Theranostic applications of nanoparticles in neurodegenerative disorders
title_full_unstemmed	Theranostic applications of nanoparticles in neurodegenerative disorders
title_sort	theranostic applications of nanoparticles in neurodegenerative disorders
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d58b611fa3c841aa9714f942805c6f7c
work_keys_str_mv	AT ramanathans theranosticapplicationsofnanoparticlesinneurodegenerativedisorders AT archunang theranosticapplicationsofnanoparticlesinneurodegenerativedisorders AT sivakumarm theranosticapplicationsofnanoparticlesinneurodegenerativedisorders AT tamilselvans theranosticapplicationsofnanoparticlesinneurodegenerativedisorders AT fredal theranosticapplicationsofnanoparticlesinneurodegenerativedisorders AT kumars theranosticapplicationsofnanoparticlesinneurodegenerativedisorders AT gulyasb theranosticapplicationsofnanoparticlesinneurodegenerativedisorders AT padmanabhanp theranosticapplicationsofnanoparticlesinneurodegenerativedisorders
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Theranostic applications of nanoparticles in neurodegenerative disorders

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