The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity

Antonia Mancuso,1 Maria Chiara Cristiano,2 Massimo Fresta,1 Donatella Paolino2 1Department of Health Sciences, University “Magna Græcia” of Catanzaro, Catanzaro 88100, Italy; 2Department of Experimental and Clinical Medicine, University “Magna Græcia...

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Autores principales:	Mancuso A, Cristiano MC, Fresta M, Paolino D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	targeted therapy skin antiacne drugs nanocarriers drug delivery systems Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d58e0988381143949e73a418603c08d4
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spelling	oai:doaj.org-article:d58e0988381143949e73a418603c08d42021-12-02T14:59:19ZThe Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity1178-2013https://doaj.org/article/d58e0988381143949e73a418603c08d42020-11-01T00:00:00Zhttps://www.dovepress.com/the-challenge-of-nanovesicles-for-selective-topical-delivery-for-acne--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Antonia Mancuso,1 Maria Chiara Cristiano,2 Massimo Fresta,1 Donatella Paolino2 1Department of Health Sciences, University “Magna Græcia” of Catanzaro, Catanzaro 88100, Italy; 2Department of Experimental and Clinical Medicine, University “Magna Græcia” of Catanzaro, Catanzaro 88100, ItalyCorrespondence: Donatella PaolinoUniversity “Magna Græcia” of Catanzaro, Viale Europa, Catanzaro 88100, ItalyTel +39 09613694211Email paolino@unicz.itAbstract: Acne is a common skin disease that affect over 80% of adolescents. It is characterized by inflammation of the hair bulb and the attached sebaceous gland. To date, many strategies have been used to treat acne as a function of the disease severity. However, common treatments for acne seem to show several side effects, from local irritation to more serious collateral effects. The use of topical vesicular carriers able to deliver active compounds is currently considered as an excellent approach in the treatment of different skin diseases. Many results in the literature have proven that drug delivery systems are useful in overcoming the toxicity induced by common drug therapies, while maintaining their therapeutic efficacy. Starting from these assumptions, the authors reviewed drug delivery systems already realized for the topical treatment of acne, with a focus on their limitations and advantages over conventional treatment strategies. Although their exact mechanism of permeation is not often completely clear, deformable vesicles seem to be the best solution for obtaining a specific delivery of drugs into the deeper skin layers, with consequent increased local action and minimized collateral effects.Keywords: targeted therapy, skin, anti-acne drugs, nanocarriers, drug delivery systemsMancuso ACristiano MCFresta MPaolino DDove Medical Pressarticletargeted therapyskinantiacne drugsnanocarriersdrug delivery systemsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 9197-9210 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	targeted therapy skin antiacne drugs nanocarriers drug delivery systems Medicine (General) R5-920
spellingShingle	targeted therapy skin antiacne drugs nanocarriers drug delivery systems Medicine (General) R5-920 Mancuso A Cristiano MC Fresta M Paolino D The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity
description	Antonia Mancuso,1 Maria Chiara Cristiano,2 Massimo Fresta,1 Donatella Paolino2 1Department of Health Sciences, University “Magna Græcia” of Catanzaro, Catanzaro 88100, Italy; 2Department of Experimental and Clinical Medicine, University “Magna Græcia” of Catanzaro, Catanzaro 88100, ItalyCorrespondence: Donatella PaolinoUniversity “Magna Græcia” of Catanzaro, Viale Europa, Catanzaro 88100, ItalyTel +39 09613694211Email paolino@unicz.itAbstract: Acne is a common skin disease that affect over 80% of adolescents. It is characterized by inflammation of the hair bulb and the attached sebaceous gland. To date, many strategies have been used to treat acne as a function of the disease severity. However, common treatments for acne seem to show several side effects, from local irritation to more serious collateral effects. The use of topical vesicular carriers able to deliver active compounds is currently considered as an excellent approach in the treatment of different skin diseases. Many results in the literature have proven that drug delivery systems are useful in overcoming the toxicity induced by common drug therapies, while maintaining their therapeutic efficacy. Starting from these assumptions, the authors reviewed drug delivery systems already realized for the topical treatment of acne, with a focus on their limitations and advantages over conventional treatment strategies. Although their exact mechanism of permeation is not often completely clear, deformable vesicles seem to be the best solution for obtaining a specific delivery of drugs into the deeper skin layers, with consequent increased local action and minimized collateral effects.Keywords: targeted therapy, skin, anti-acne drugs, nanocarriers, drug delivery systems
format	article
author	Mancuso A Cristiano MC Fresta M Paolino D
author_facet	Mancuso A Cristiano MC Fresta M Paolino D
author_sort	Mancuso A
title	The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity
title_short	The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity
title_full	The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity
title_fullStr	The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity
title_full_unstemmed	The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity
title_sort	challenge of nanovesicles for selective topical delivery for acne treatment: enhancing absorption whilst avoiding toxicity
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d58e0988381143949e73a418603c08d4
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The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity

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