Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation

There are no targeted pharmacologic therapies to treat lung injury during mechanical ventilation (MV). Here the authors identify a mechanosensitive microRNA (miR-146a) in alveolar macrophages during MV and increase miR-146a to supraphysiological levels in these cells to mitigate ventilator induced l...

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Autores principales:	Christopher M. Bobba, Qinqin Fei, Vasudha Shukla, Hyunwook Lee, Pragi Patel, Rachel K. Putman, Carleen Spitzer, MuChun Tsai, Mark D. Wewers, Robert J. Lee, John W. Christman, Megan N. Ballinger, Samir N. Ghadiali, Joshua A. Englert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d590e28056334e1c821dbc94a711313f
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spelling	oai:doaj.org-article:d590e28056334e1c821dbc94a711313f2021-12-02T15:22:39ZNanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation10.1038/s41467-020-20449-w2041-1723https://doaj.org/article/d590e28056334e1c821dbc94a711313f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20449-whttps://doaj.org/toc/2041-1723There are no targeted pharmacologic therapies to treat lung injury during mechanical ventilation (MV). Here the authors identify a mechanosensitive microRNA (miR-146a) in alveolar macrophages during MV and increase miR-146a to supraphysiological levels in these cells to mitigate ventilator induced lung injury.Christopher M. BobbaQinqin FeiVasudha ShuklaHyunwook LeePragi PatelRachel K. PutmanCarleen SpitzerMuChun TsaiMark D. WewersRobert J. LeeJohn W. ChristmanMegan N. BallingerSamir N. GhadialiJoshua A. EnglertNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher M. Bobba Qinqin Fei Vasudha Shukla Hyunwook Lee Pragi Patel Rachel K. Putman Carleen Spitzer MuChun Tsai Mark D. Wewers Robert J. Lee John W. Christman Megan N. Ballinger Samir N. Ghadiali Joshua A. Englert Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation
description	There are no targeted pharmacologic therapies to treat lung injury during mechanical ventilation (MV). Here the authors identify a mechanosensitive microRNA (miR-146a) in alveolar macrophages during MV and increase miR-146a to supraphysiological levels in these cells to mitigate ventilator induced lung injury.
format	article
author	Christopher M. Bobba Qinqin Fei Vasudha Shukla Hyunwook Lee Pragi Patel Rachel K. Putman Carleen Spitzer MuChun Tsai Mark D. Wewers Robert J. Lee John W. Christman Megan N. Ballinger Samir N. Ghadiali Joshua A. Englert
author_facet	Christopher M. Bobba Qinqin Fei Vasudha Shukla Hyunwook Lee Pragi Patel Rachel K. Putman Carleen Spitzer MuChun Tsai Mark D. Wewers Robert J. Lee John W. Christman Megan N. Ballinger Samir N. Ghadiali Joshua A. Englert
author_sort	Christopher M. Bobba
title	Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation
title_short	Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation
title_full	Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation
title_fullStr	Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation
title_full_unstemmed	Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation
title_sort	nanoparticle delivery of microrna-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d590e28056334e1c821dbc94a711313f
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Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation

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