A carbon nanotube integrated microfluidic device for blood plasma extraction

Abstract Blood is a complex fluid consisting of cells and plasma. Plasma contains key biomarkers essential for disease diagnosis and therapeutic monitoring. Thus, by separating plasma from the blood, it is possible to analyze these biomarkers. Conventional methods for plasma extraction involve bulky...

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Autores principales:	Yin-Ting Yeh, Zhong Lin, Si-Yang Zheng, Mauricio Terrones
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Carbon Nanotubes (CNTs) Plasma Infusion Microfluidic Devices Aligned CNTs Separate Plasma Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d590fd51b1a9461c9e7778556b49b12c
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spelling	oai:doaj.org-article:d590fd51b1a9461c9e7778556b49b12c2021-12-02T15:07:50ZA carbon nanotube integrated microfluidic device for blood plasma extraction10.1038/s41598-018-31810-x2045-2322https://doaj.org/article/d590fd51b1a9461c9e7778556b49b12c2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31810-xhttps://doaj.org/toc/2045-2322Abstract Blood is a complex fluid consisting of cells and plasma. Plasma contains key biomarkers essential for disease diagnosis and therapeutic monitoring. Thus, by separating plasma from the blood, it is possible to analyze these biomarkers. Conventional methods for plasma extraction involve bulky equipment, and miniaturization constitutes a key step to develop portable devices for plasma extraction. Here, we integrated nanomaterial synthesis with microfabrication, and built a microfluidic device. In particular, we designed a double-spiral channel able to perform cross-flow filtration. This channel was constructed by growing aligned carbon nanotubes (CNTs) with average inter-tubular distances of ~80 nm, which resulted in porosity values of ~93%. During blood extraction, these aligned CNTs allow smaller molecules (e.g., proteins) to pass through the channel wall, while larger molecules (e.g., cells) get blocked. Our results show that our device effectively separates plasma from blood, by trapping blood cells. We successfully recovered albumin -the most abundant protein inside plasma- with an efficiency of ~80%. This work constitutes the first report on integrating biocompatible nitrogen-doped CNT (CNxCNT) arrays to extract plasma from human blood, thus widening the bio-applications of CNTs.Yin-Ting YehZhong LinSi-Yang ZhengMauricio TerronesNature PortfolioarticleCarbon Nanotubes (CNTs)Plasma InfusionMicrofluidic DevicesAligned CNTsSeparate PlasmaMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Carbon Nanotubes (CNTs) Plasma Infusion Microfluidic Devices Aligned CNTs Separate Plasma Medicine R Science Q
spellingShingle	Carbon Nanotubes (CNTs) Plasma Infusion Microfluidic Devices Aligned CNTs Separate Plasma Medicine R Science Q Yin-Ting Yeh Zhong Lin Si-Yang Zheng Mauricio Terrones A carbon nanotube integrated microfluidic device for blood plasma extraction
description	Abstract Blood is a complex fluid consisting of cells and plasma. Plasma contains key biomarkers essential for disease diagnosis and therapeutic monitoring. Thus, by separating plasma from the blood, it is possible to analyze these biomarkers. Conventional methods for plasma extraction involve bulky equipment, and miniaturization constitutes a key step to develop portable devices for plasma extraction. Here, we integrated nanomaterial synthesis with microfabrication, and built a microfluidic device. In particular, we designed a double-spiral channel able to perform cross-flow filtration. This channel was constructed by growing aligned carbon nanotubes (CNTs) with average inter-tubular distances of ~80 nm, which resulted in porosity values of ~93%. During blood extraction, these aligned CNTs allow smaller molecules (e.g., proteins) to pass through the channel wall, while larger molecules (e.g., cells) get blocked. Our results show that our device effectively separates plasma from blood, by trapping blood cells. We successfully recovered albumin -the most abundant protein inside plasma- with an efficiency of ~80%. This work constitutes the first report on integrating biocompatible nitrogen-doped CNT (CNxCNT) arrays to extract plasma from human blood, thus widening the bio-applications of CNTs.
format	article
author	Yin-Ting Yeh Zhong Lin Si-Yang Zheng Mauricio Terrones
author_facet	Yin-Ting Yeh Zhong Lin Si-Yang Zheng Mauricio Terrones
author_sort	Yin-Ting Yeh
title	A carbon nanotube integrated microfluidic device for blood plasma extraction
title_short	A carbon nanotube integrated microfluidic device for blood plasma extraction
title_full	A carbon nanotube integrated microfluidic device for blood plasma extraction
title_fullStr	A carbon nanotube integrated microfluidic device for blood plasma extraction
title_full_unstemmed	A carbon nanotube integrated microfluidic device for blood plasma extraction
title_sort	carbon nanotube integrated microfluidic device for blood plasma extraction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d590fd51b1a9461c9e7778556b49b12c
work_keys_str_mv	AT yintingyeh acarbonnanotubeintegratedmicrofluidicdeviceforbloodplasmaextraction AT zhonglin acarbonnanotubeintegratedmicrofluidicdeviceforbloodplasmaextraction AT siyangzheng acarbonnanotubeintegratedmicrofluidicdeviceforbloodplasmaextraction AT mauricioterrones acarbonnanotubeintegratedmicrofluidicdeviceforbloodplasmaextraction AT yintingyeh carbonnanotubeintegratedmicrofluidicdeviceforbloodplasmaextraction AT zhonglin carbonnanotubeintegratedmicrofluidicdeviceforbloodplasmaextraction AT siyangzheng carbonnanotubeintegratedmicrofluidicdeviceforbloodplasmaextraction AT mauricioterrones carbonnanotubeintegratedmicrofluidicdeviceforbloodplasmaextraction
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A carbon nanotube integrated microfluidic device for blood plasma extraction

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