APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression

APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression

Ribose-5-phosphate (R5P) is required for DNA synthesis, but how this is regulated during cell cycle progression is unclear. Here the authors report that the cell cycle regulator APC/C-CDH1 synchronizes cell cycle progression with R5P-derived DNA synthesis by controlling TKTL1 stability

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Autores principales: Yang Li, Cui-Fang Yao, Fu-Jiang Xu, Yuan-Yuan Qu, Jia-Tao Li, Yan Lin, Zhong-Lian Cao, Peng-Cheng Lin, Wei Xu, Shi-Min Zhao, Jian-Yuan Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/d591a17fbdbb4850adeccbc50eaabd50
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spelling oai:doaj.org-article:d591a17fbdbb4850adeccbc50eaabd502021-12-02T14:35:49ZAPC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression10.1038/s41467-019-10375-x2041-1723https://doaj.org/article/d591a17fbdbb4850adeccbc50eaabd502019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10375-xhttps://doaj.org/toc/2041-1723Ribose-5-phosphate (R5P) is required for DNA synthesis, but how this is regulated during cell cycle progression is unclear. Here the authors report that the cell cycle regulator APC/C-CDH1 synchronizes cell cycle progression with R5P-derived DNA synthesis by controlling TKTL1 stabilityYang LiCui-Fang YaoFu-Jiang XuYuan-Yuan QuJia-Tao LiYan LinZhong-Lian CaoPeng-Cheng LinWei XuShi-Min ZhaoJian-Yuan ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yang Li
Cui-Fang Yao
Fu-Jiang Xu
Yuan-Yuan Qu
Jia-Tao Li
Yan Lin
Zhong-Lian Cao
Peng-Cheng Lin
Wei Xu
Shi-Min Zhao
Jian-Yuan Zhao
APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression
description Ribose-5-phosphate (R5P) is required for DNA synthesis, but how this is regulated during cell cycle progression is unclear. Here the authors report that the cell cycle regulator APC/C-CDH1 synchronizes cell cycle progression with R5P-derived DNA synthesis by controlling TKTL1 stability
format article
author Yang Li
Cui-Fang Yao
Fu-Jiang Xu
Yuan-Yuan Qu
Jia-Tao Li
Yan Lin
Zhong-Lian Cao
Peng-Cheng Lin
Wei Xu
Shi-Min Zhao
Jian-Yuan Zhao
author_facet Yang Li
Cui-Fang Yao
Fu-Jiang Xu
Yuan-Yuan Qu
Jia-Tao Li
Yan Lin
Zhong-Lian Cao
Peng-Cheng Lin
Wei Xu
Shi-Min Zhao
Jian-Yuan Zhao
author_sort Yang Li
title APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression
title_short APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression
title_full APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression
title_fullStr APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression
title_full_unstemmed APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression
title_sort apc/ccdh1 synchronizes ribose-5-phosphate levels and dna synthesis to cell cycle progression
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/d591a17fbdbb4850adeccbc50eaabd50
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