Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery

Chang Li,1 Chunmeng Sun,1 Shasha Li,1 Peng Han,2 Huimin Sun,3 Ammar Ouahab,1 Yan Shen,1 Yourui Xu,1 Yerong Xiong,1 Jiasheng Tu11State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 2Chinese Pharmacopoeia Commission, Beijing, 3National Ins...

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Autores principales:	Li C, Sun C, Li S, Han P, Sun H, Ouahab A, Shen Y, Xu Y, Xiong Y, Tu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d591bf8e42e94527bb30ef3d7af373ed
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spelling	oai:doaj.org-article:d591bf8e42e94527bb30ef3d7af373ed2021-12-02T05:02:06ZNovel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery1178-2013https://doaj.org/article/d591bf8e42e94527bb30ef3d7af373ed2014-04-01T00:00:00Zhttp://www.dovepress.com/novel-designed-polyoxyethylene-nonionic-surfactant-with-improved-safet-a16578https://doaj.org/toc/1178-2013 Chang Li,1 Chunmeng Sun,1 Shasha Li,1 Peng Han,2 Huimin Sun,3 Ammar Ouahab,1 Yan Shen,1 Yourui Xu,1 Yerong Xiong,1 Jiasheng Tu11State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 2Chinese Pharmacopoeia Commission, Beijing, 3National Institute for Food and Drug Control, Beijing, People's Republic of ChinaAbstract: In order to limit the adverse reactions caused by polysorbate 80 in Taxotere®, a widely used formulation of docetaxel, a safe and effective nanocarrier for this drug has been developed based on micelles formed by a new class of well-defined polyoxyethylene sorbitol oleate (PSO) with sorbitol as the matrix in aqueous solution. The physicochemical properties of the amphiphilic surfactant and the resulting micelles can be easily fine-tuned by the homogeneous sorbitol matrix and pure oleic acid. Composition, critical micelle concentration, and entrapment efficiency were investigated by ultraviolet visible spectroscopy, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, fluorospectrophotometry, and high-performance liquid chromatography. In vitro and in vivo evaluation revealed that PSO had exceptionally low hemolysis and histamine release rates compared with commercial polysorbate 80. Moreover, the tumor targeting delivery of PSO was investigated by in vivo imaging in S180 tumor-bearing mice. The results suggest that this novel delivery system, PSO, provides an acceptable alternative to polysorbate 80 for delivery of docetaxel. Further, due to the hypoallergenic nature of PSO, the mechanism of pseudoallergy caused by the polyoxyethylene nonionic surfactant was investigated. Based on in vitro cell analysis, it was assumed that the initial contact of polyoxyethylene nonionic surfactant with mast cells provoked pseudoallergy via polyamine receptor-mediated endocytosis.Keywords: polyoxyethylene nonionic surfactant, sorbitol, isosorbide, pseudoallergy, docetaxelLi CSun CLi SHan PSun HOuahab AShen YXu YXiong YTu JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2089-2100 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Li C Sun C Li S Han P Sun H Ouahab A Shen Y Xu Y Xiong Y Tu J Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery
description	Chang Li,1 Chunmeng Sun,1 Shasha Li,1 Peng Han,2 Huimin Sun,3 Ammar Ouahab,1 Yan Shen,1 Yourui Xu,1 Yerong Xiong,1 Jiasheng Tu11State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 2Chinese Pharmacopoeia Commission, Beijing, 3National Institute for Food and Drug Control, Beijing, People's Republic of ChinaAbstract: In order to limit the adverse reactions caused by polysorbate 80 in Taxotere®, a widely used formulation of docetaxel, a safe and effective nanocarrier for this drug has been developed based on micelles formed by a new class of well-defined polyoxyethylene sorbitol oleate (PSO) with sorbitol as the matrix in aqueous solution. The physicochemical properties of the amphiphilic surfactant and the resulting micelles can be easily fine-tuned by the homogeneous sorbitol matrix and pure oleic acid. Composition, critical micelle concentration, and entrapment efficiency were investigated by ultraviolet visible spectroscopy, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, fluorospectrophotometry, and high-performance liquid chromatography. In vitro and in vivo evaluation revealed that PSO had exceptionally low hemolysis and histamine release rates compared with commercial polysorbate 80. Moreover, the tumor targeting delivery of PSO was investigated by in vivo imaging in S180 tumor-bearing mice. The results suggest that this novel delivery system, PSO, provides an acceptable alternative to polysorbate 80 for delivery of docetaxel. Further, due to the hypoallergenic nature of PSO, the mechanism of pseudoallergy caused by the polyoxyethylene nonionic surfactant was investigated. Based on in vitro cell analysis, it was assumed that the initial contact of polyoxyethylene nonionic surfactant with mast cells provoked pseudoallergy via polyamine receptor-mediated endocytosis.Keywords: polyoxyethylene nonionic surfactant, sorbitol, isosorbide, pseudoallergy, docetaxel
format	article
author	Li C Sun C Li S Han P Sun H Ouahab A Shen Y Xu Y Xiong Y Tu J
author_facet	Li C Sun C Li S Han P Sun H Ouahab A Shen Y Xu Y Xiong Y Tu J
author_sort	Li C
title	Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery
title_short	Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery
title_full	Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery
title_fullStr	Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery
title_full_unstemmed	Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery
title_sort	novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/d591bf8e42e94527bb30ef3d7af373ed
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Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery

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