Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice

Abstract Alliin (S-allyl cysteine sulfoxide) is a bioactive sulfoxide compound derived from garlic. To evaluate the preventive effect of alliin against metabolic risk factors in diet induced obese (DIO) mice, we treated the C57BL/6J DIO mice with drinking water with or without alliin (0.1 mg/ml) for...

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Autores principales:	Baiqiang Zhai, Chuanhai Zhang, Yao Sheng, Changhui Zhao, Xiaoyun He, Wentao Xu, Kunlun Huang, Yunbo Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d592d012eaf440e78649dd72c1c0a851
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id	oai:doaj.org-article:d592d012eaf440e78649dd72c1c0a851
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spelling	oai:doaj.org-article:d592d012eaf440e78649dd72c1c0a8512021-12-02T11:40:36ZHypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice10.1038/s41598-018-21421-x2045-2322https://doaj.org/article/d592d012eaf440e78649dd72c1c0a8512018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21421-xhttps://doaj.org/toc/2045-2322Abstract Alliin (S-allyl cysteine sulfoxide) is a bioactive sulfoxide compound derived from garlic. To evaluate the preventive effect of alliin against metabolic risk factors in diet induced obese (DIO) mice, we treated the C57BL/6J DIO mice with drinking water with or without alliin (0.1 mg/ml) for 8 weeks. Results showed that alliin had no significant effect on the body weight, adiposity or energy balance. However, alliin treatment enhanced glucose homeostasis, increased insulin sensitivity and improved the lipid profile in the DIO mice. This was, at least partly, attributable to alliin induced modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae. From above, we conclude that alliin has nutraceutical or even medicinal potential in prevention of diabetes and lipid metabolic disorders.Baiqiang ZhaiChuanhai ZhangYao ShengChanghui ZhaoXiaoyun HeWentao XuKunlun HuangYunbo LuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Baiqiang Zhai Chuanhai Zhang Yao Sheng Changhui Zhao Xiaoyun He Wentao Xu Kunlun Huang Yunbo Luo Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice
description	Abstract Alliin (S-allyl cysteine sulfoxide) is a bioactive sulfoxide compound derived from garlic. To evaluate the preventive effect of alliin against metabolic risk factors in diet induced obese (DIO) mice, we treated the C57BL/6J DIO mice with drinking water with or without alliin (0.1 mg/ml) for 8 weeks. Results showed that alliin had no significant effect on the body weight, adiposity or energy balance. However, alliin treatment enhanced glucose homeostasis, increased insulin sensitivity and improved the lipid profile in the DIO mice. This was, at least partly, attributable to alliin induced modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae. From above, we conclude that alliin has nutraceutical or even medicinal potential in prevention of diabetes and lipid metabolic disorders.
format	article
author	Baiqiang Zhai Chuanhai Zhang Yao Sheng Changhui Zhao Xiaoyun He Wentao Xu Kunlun Huang Yunbo Luo
author_facet	Baiqiang Zhai Chuanhai Zhang Yao Sheng Changhui Zhao Xiaoyun He Wentao Xu Kunlun Huang Yunbo Luo
author_sort	Baiqiang Zhai
title	Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice
title_short	Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice
title_full	Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice
title_fullStr	Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice
title_full_unstemmed	Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice
title_sort	hypoglycemic and hypolipidemic effect of s-allyl-cysteine sulfoxide (alliin) in dio mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d592d012eaf440e78649dd72c1c0a851
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Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice

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