Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines

Immune response against tissue-specific antigens is a hallmark of autoimmunity. Here the authors show that a single autoantigen-based nanomedicine can ameliorate pathology in a broad range of liver autoimmunity models without impairing host defenses, suggesting organ-wide tolerization.

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Autores principales:	Channakeshava Sokke Umeshappa, Santiswarup Singha, Jesus Blanco, Kun Shao, Roopa Hebbandi Nanjundappa, Jun Yamanouchi, Albert Parés, Pau Serra, Yang Yang, Pere Santamaria
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d597958e29974428be28085b0fd4c0ca
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spelling	oai:doaj.org-article:d597958e29974428be28085b0fd4c0ca2021-12-02T17:33:22ZSuppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines10.1038/s41467-019-09893-52041-1723https://doaj.org/article/d597958e29974428be28085b0fd4c0ca2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09893-5https://doaj.org/toc/2041-1723Immune response against tissue-specific antigens is a hallmark of autoimmunity. Here the authors show that a single autoantigen-based nanomedicine can ameliorate pathology in a broad range of liver autoimmunity models without impairing host defenses, suggesting organ-wide tolerization.Channakeshava Sokke UmeshappaSantiswarup SinghaJesus BlancoKun ShaoRoopa Hebbandi NanjundappaJun YamanouchiAlbert ParésPau SerraYang YangPere SantamariaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Channakeshava Sokke Umeshappa Santiswarup Singha Jesus Blanco Kun Shao Roopa Hebbandi Nanjundappa Jun Yamanouchi Albert Parés Pau Serra Yang Yang Pere Santamaria Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines
description	Immune response against tissue-specific antigens is a hallmark of autoimmunity. Here the authors show that a single autoantigen-based nanomedicine can ameliorate pathology in a broad range of liver autoimmunity models without impairing host defenses, suggesting organ-wide tolerization.
format	article
author	Channakeshava Sokke Umeshappa Santiswarup Singha Jesus Blanco Kun Shao Roopa Hebbandi Nanjundappa Jun Yamanouchi Albert Parés Pau Serra Yang Yang Pere Santamaria
author_facet	Channakeshava Sokke Umeshappa Santiswarup Singha Jesus Blanco Kun Shao Roopa Hebbandi Nanjundappa Jun Yamanouchi Albert Parés Pau Serra Yang Yang Pere Santamaria
author_sort	Channakeshava Sokke Umeshappa
title	Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines
title_short	Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines
title_full	Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines
title_fullStr	Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines
title_full_unstemmed	Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines
title_sort	suppression of a broad spectrum of liver autoimmune pathologies by single peptide-mhc-based nanomedicines
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d597958e29974428be28085b0fd4c0ca
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Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines

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