Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines

Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines

Immune response against tissue-specific antigens is a hallmark of autoimmunity. Here the authors show that a single autoantigen-based nanomedicine can ameliorate pathology in a broad range of liver autoimmunity models without impairing host defenses, suggesting organ-wide tolerization.

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Detalles Bibliográficos
Autores principales: Channakeshava Sokke Umeshappa, Santiswarup Singha, Jesus Blanco, Kun Shao, Roopa Hebbandi Nanjundappa, Jun Yamanouchi, Albert Parés, Pau Serra, Yang Yang, Pere Santamaria
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d597958e29974428be28085b0fd4c0ca
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