Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.

<h4>Background</h4>Fetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally, demonstrate any abnormality in the...

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Autores principales: Silvia Pisaneschi, Francesca A L Strigini, Angel M Sanchez, Silvia Begliuomini, Elena Casarosa, Andrea Ripoli, Paolo Ghirri, Antonio Boldrini, Bruno Fink, Andrea R Genazzani, Flavio Coceani, Tommaso Simoncini
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spelling oai:doaj.org-article:d59bbcc8bcc74fe3a09003051b2691e22021-11-18T07:04:12ZCompensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.1932-620310.1371/journal.pone.0045294https://doaj.org/article/d59bbcc8bcc74fe3a09003051b2691e22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23028913/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Fetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally, demonstrate any abnormality in the nitric oxide system.<h4>Methods</h4>Prenatal assessment of feto-placental vascular function was combined with measurement of nitric oxide (in the form of S-nitrosohemoglobin) and its nitrite byproduct, and of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine. Umbilical vein endothelial cells were also harvested to determine their gene profile. The study comprised term pregnancies with normal (n = 40) or small-for-gestational-age (n = 20) newborns, small-for-gestational-age preterm pregnancies (n = 15), and bi-chorial, bi-amniotic twin pregnancies with discordant fetal growth (n = 12).<h4>Results</h4>Umbilical blood nitrite (p<0.001) and S-nitrosohemoglobin (p = 0.02) rose with fetal growth restriction while asymmetric dimethylarginine decreased (p = 0.003). Nitrite rise coincided with an abnormal Doppler profile from umbilical arteries. Fetal growth restriction umbilical vein endothelial cells produced more nitrite and also exhibited reciprocal changes in vasodilator (upwards) and vasoconstrictor (downwards) transcripts. Elevation in blood nitrite and S-nitrosohemoglobin persisted postnatally in the fetal growth restriction offspring.<h4>Conclusion</h4>Fetal growth restriction is typified by increased nitric oxide production during pregnancy and after birth. This response is viewed as an adaptative event to sustain placental blood flow. However, its occurrence may modify the endothelial phenotype and may ultimately represent an element of risk for cardiovascular disease in adult life.Silvia PisaneschiFrancesca A L StriginiAngel M SanchezSilvia BegliuominiElena CasarosaAndrea RipoliPaolo GhirriAntonio BoldriniBruno FinkAndrea R GenazzaniFlavio CoceaniTommaso SimonciniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e45294 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Silvia Pisaneschi
Francesca A L Strigini
Angel M Sanchez
Silvia Begliuomini
Elena Casarosa
Andrea Ripoli
Paolo Ghirri
Antonio Boldrini
Bruno Fink
Andrea R Genazzani
Flavio Coceani
Tommaso Simoncini
Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.
description <h4>Background</h4>Fetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally, demonstrate any abnormality in the nitric oxide system.<h4>Methods</h4>Prenatal assessment of feto-placental vascular function was combined with measurement of nitric oxide (in the form of S-nitrosohemoglobin) and its nitrite byproduct, and of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine. Umbilical vein endothelial cells were also harvested to determine their gene profile. The study comprised term pregnancies with normal (n = 40) or small-for-gestational-age (n = 20) newborns, small-for-gestational-age preterm pregnancies (n = 15), and bi-chorial, bi-amniotic twin pregnancies with discordant fetal growth (n = 12).<h4>Results</h4>Umbilical blood nitrite (p<0.001) and S-nitrosohemoglobin (p = 0.02) rose with fetal growth restriction while asymmetric dimethylarginine decreased (p = 0.003). Nitrite rise coincided with an abnormal Doppler profile from umbilical arteries. Fetal growth restriction umbilical vein endothelial cells produced more nitrite and also exhibited reciprocal changes in vasodilator (upwards) and vasoconstrictor (downwards) transcripts. Elevation in blood nitrite and S-nitrosohemoglobin persisted postnatally in the fetal growth restriction offspring.<h4>Conclusion</h4>Fetal growth restriction is typified by increased nitric oxide production during pregnancy and after birth. This response is viewed as an adaptative event to sustain placental blood flow. However, its occurrence may modify the endothelial phenotype and may ultimately represent an element of risk for cardiovascular disease in adult life.
format article
author Silvia Pisaneschi
Francesca A L Strigini
Angel M Sanchez
Silvia Begliuomini
Elena Casarosa
Andrea Ripoli
Paolo Ghirri
Antonio Boldrini
Bruno Fink
Andrea R Genazzani
Flavio Coceani
Tommaso Simoncini
author_facet Silvia Pisaneschi
Francesca A L Strigini
Angel M Sanchez
Silvia Begliuomini
Elena Casarosa
Andrea Ripoli
Paolo Ghirri
Antonio Boldrini
Bruno Fink
Andrea R Genazzani
Flavio Coceani
Tommaso Simoncini
author_sort Silvia Pisaneschi
title Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.
title_short Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.
title_full Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.
title_fullStr Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.
title_full_unstemmed Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.
title_sort compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/d59bbcc8bcc74fe3a09003051b2691e2
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