State of the Art in Hepatic Dysfunction in Pregnancy

Hepatic dysfunction in pregnant women is always challenging for the obstetrician, as the spectrum of hepatic abnormalities can be very large and have various implications, both for mother and fetus. There is a diagnostic and therapeutic polymorphism of hepatic dysfunction in pregnancy and insufficie...

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Autores principales:	Valentin Nicolae Varlas, Roxana Bohîlțea, Gina Gheorghe, Georgiana Bostan, Gabriela Anca Angelescu, Ovidiu Nicolae Penes, Roxana Georgiana Bors, Eliza Cloțea, Nicolae Bacalbasa, Camelia Cristina Diaconu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pregnancy liver dysfunction hyperemesis gravidarum HELLP syndrome acute fatty liver intrahepatic cholestasis Medicine R
Acceso en línea:	https://doaj.org/article/d59c210e3683464baf8d97c6b473d3fa
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spelling	oai:doaj.org-article:d59c210e3683464baf8d97c6b473d3fa2021-11-25T17:44:34ZState of the Art in Hepatic Dysfunction in Pregnancy10.3390/healthcare91114812227-9032https://doaj.org/article/d59c210e3683464baf8d97c6b473d3fa2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1481https://doaj.org/toc/2227-9032Hepatic dysfunction in pregnant women is always challenging for the obstetrician, as the spectrum of hepatic abnormalities can be very large and have various implications, both for mother and fetus. There is a diagnostic and therapeutic polymorphism of hepatic dysfunction in pregnancy and insufficient knowledge related to the etiopathogenesis and epidemiology of this disease. The clinical forms of hepatic dysfunction encountered in pregnancy can vary from liver diseases related to pregnancy (e.g., HELLP syndrome, intrahepatic cholestasis, hyperemesis gravidarum, or acute fatty liver of pregnancy) to de novo ones occurring in pregnancy, and pre-existing liver disease (cholelithiasis, Budd–Chiari syndrome, and cirrhosis). We performed a systematic literature search over 10 years. The review protocol assumed a search of two databases (PubMed<sup>®</sup>/MEDLINE and Web of Science Core Collection). The strategy regarding the management of these diseases involves multidisciplinary teams composed of different specialists (obstetricians, gastroenterologists and anesthetists) from specialized tertiary centers. Despite the improving prognosis of pregnant women with liver diseases, the risk of maternal–fetal complications remains very high. Therefore, it is necessary to ensure careful monitoring by a multidisciplinary team and to inform the patients of the potential risks.Valentin Nicolae VarlasRoxana BohîlțeaGina GheorgheGeorgiana BostanGabriela Anca AngelescuOvidiu Nicolae PenesRoxana Georgiana BorsEliza CloțeaNicolae BacalbasaCamelia Cristina DiaconuMDPI AGarticlepregnancyliver dysfunctionhyperemesis gravidarumHELLP syndromeacute fatty liverintrahepatic cholestasisMedicineRENHealthcare, Vol 9, Iss 1481, p 1481 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pregnancy liver dysfunction hyperemesis gravidarum HELLP syndrome acute fatty liver intrahepatic cholestasis Medicine R
spellingShingle	pregnancy liver dysfunction hyperemesis gravidarum HELLP syndrome acute fatty liver intrahepatic cholestasis Medicine R Valentin Nicolae Varlas Roxana Bohîlțea Gina Gheorghe Georgiana Bostan Gabriela Anca Angelescu Ovidiu Nicolae Penes Roxana Georgiana Bors Eliza Cloțea Nicolae Bacalbasa Camelia Cristina Diaconu State of the Art in Hepatic Dysfunction in Pregnancy
description	Hepatic dysfunction in pregnant women is always challenging for the obstetrician, as the spectrum of hepatic abnormalities can be very large and have various implications, both for mother and fetus. There is a diagnostic and therapeutic polymorphism of hepatic dysfunction in pregnancy and insufficient knowledge related to the etiopathogenesis and epidemiology of this disease. The clinical forms of hepatic dysfunction encountered in pregnancy can vary from liver diseases related to pregnancy (e.g., HELLP syndrome, intrahepatic cholestasis, hyperemesis gravidarum, or acute fatty liver of pregnancy) to de novo ones occurring in pregnancy, and pre-existing liver disease (cholelithiasis, Budd–Chiari syndrome, and cirrhosis). We performed a systematic literature search over 10 years. The review protocol assumed a search of two databases (PubMed<sup>®</sup>/MEDLINE and Web of Science Core Collection). The strategy regarding the management of these diseases involves multidisciplinary teams composed of different specialists (obstetricians, gastroenterologists and anesthetists) from specialized tertiary centers. Despite the improving prognosis of pregnant women with liver diseases, the risk of maternal–fetal complications remains very high. Therefore, it is necessary to ensure careful monitoring by a multidisciplinary team and to inform the patients of the potential risks.
format	article
author	Valentin Nicolae Varlas Roxana Bohîlțea Gina Gheorghe Georgiana Bostan Gabriela Anca Angelescu Ovidiu Nicolae Penes Roxana Georgiana Bors Eliza Cloțea Nicolae Bacalbasa Camelia Cristina Diaconu
author_facet	Valentin Nicolae Varlas Roxana Bohîlțea Gina Gheorghe Georgiana Bostan Gabriela Anca Angelescu Ovidiu Nicolae Penes Roxana Georgiana Bors Eliza Cloțea Nicolae Bacalbasa Camelia Cristina Diaconu
author_sort	Valentin Nicolae Varlas
title	State of the Art in Hepatic Dysfunction in Pregnancy
title_short	State of the Art in Hepatic Dysfunction in Pregnancy
title_full	State of the Art in Hepatic Dysfunction in Pregnancy
title_fullStr	State of the Art in Hepatic Dysfunction in Pregnancy
title_full_unstemmed	State of the Art in Hepatic Dysfunction in Pregnancy
title_sort	state of the art in hepatic dysfunction in pregnancy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d59c210e3683464baf8d97c6b473d3fa
work_keys_str_mv	AT valentinnicolaevarlas stateoftheartinhepaticdysfunctioninpregnancy AT roxanabohiltea stateoftheartinhepaticdysfunctioninpregnancy AT ginagheorghe stateoftheartinhepaticdysfunctioninpregnancy AT georgianabostan stateoftheartinhepaticdysfunctioninpregnancy AT gabrielaancaangelescu stateoftheartinhepaticdysfunctioninpregnancy AT ovidiunicolaepenes stateoftheartinhepaticdysfunctioninpregnancy AT roxanageorgianabors stateoftheartinhepaticdysfunctioninpregnancy AT elizaclotea stateoftheartinhepaticdysfunctioninpregnancy AT nicolaebacalbasa stateoftheartinhepaticdysfunctioninpregnancy AT cameliacristinadiaconu stateoftheartinhepaticdysfunctioninpregnancy
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State of the Art in Hepatic Dysfunction in Pregnancy

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