Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop

Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop

The authors show that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response. These data suggest that NDR1 has an important role in controlling viral infections.

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Detalles Bibliográficos
Autores principales: Zhiyong Liu, Qiang Qin, Cheng Wu, Hui Li, Jia’nan Shou, Yuting Yang, Meidi Gu, Chunmei Ma, Wenlong Lin, Yan Zou, Yuanyuan Zhang, Feng Ma, Jihong Sun, Xiaojian Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/d59c6d3a9c14437cb40ab25d20d919d7
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Descripción
Sumario:The authors show that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response. These data suggest that NDR1 has an important role in controlling viral infections.

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