Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop

Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop

The authors show that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response. These data suggest that NDR1 has an important role in controlling viral infections.

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Autores principales: Zhiyong Liu, Qiang Qin, Cheng Wu, Hui Li, Jia’nan Shou, Yuting Yang, Meidi Gu, Chunmei Ma, Wenlong Lin, Yan Zou, Yuanyuan Zhang, Feng Ma, Jihong Sun, Xiaojian Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d59c6d3a9c14437cb40ab25d20d919d7
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spelling oai:doaj.org-article:d59c6d3a9c14437cb40ab25d20d919d72021-12-02T14:40:54ZDownregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop10.1038/s41467-018-05176-72041-1723https://doaj.org/article/d59c6d3a9c14437cb40ab25d20d919d72018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05176-7https://doaj.org/toc/2041-1723The authors show that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response. These data suggest that NDR1 has an important role in controlling viral infections.Zhiyong LiuQiang QinCheng WuHui LiJia’nan ShouYuting YangMeidi GuChunmei MaWenlong LinYan ZouYuanyuan ZhangFeng MaJihong SunXiaojian WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhiyong Liu
Qiang Qin
Cheng Wu
Hui Li
Jia’nan Shou
Yuting Yang
Meidi Gu
Chunmei Ma
Wenlong Lin
Yan Zou
Yuanyuan Zhang
Feng Ma
Jihong Sun
Xiaojian Wang
Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop
description The authors show that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response. These data suggest that NDR1 has an important role in controlling viral infections.
format article
author Zhiyong Liu
Qiang Qin
Cheng Wu
Hui Li
Jia’nan Shou
Yuting Yang
Meidi Gu
Chunmei Ma
Wenlong Lin
Yan Zou
Yuanyuan Zhang
Feng Ma
Jihong Sun
Xiaojian Wang
author_facet Zhiyong Liu
Qiang Qin
Cheng Wu
Hui Li
Jia’nan Shou
Yuting Yang
Meidi Gu
Chunmei Ma
Wenlong Lin
Yan Zou
Yuanyuan Zhang
Feng Ma
Jihong Sun
Xiaojian Wang
author_sort Zhiyong Liu
title Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop
title_short Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop
title_full Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop
title_fullStr Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop
title_full_unstemmed Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop
title_sort downregulated ndr1 protein kinase inhibits innate immune response by initiating an mir146a-stat1 feedback loop
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d59c6d3a9c14437cb40ab25d20d919d7
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AT qiangqin downregulatedndr1proteinkinaseinhibitsinnateimmuneresponsebyinitiatinganmir146astat1feedbackloop
AT chengwu downregulatedndr1proteinkinaseinhibitsinnateimmuneresponsebyinitiatinganmir146astat1feedbackloop
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AT meidigu downregulatedndr1proteinkinaseinhibitsinnateimmuneresponsebyinitiatinganmir146astat1feedbackloop
AT chunmeima downregulatedndr1proteinkinaseinhibitsinnateimmuneresponsebyinitiatinganmir146astat1feedbackloop
AT wenlonglin downregulatedndr1proteinkinaseinhibitsinnateimmuneresponsebyinitiatinganmir146astat1feedbackloop
AT yanzou downregulatedndr1proteinkinaseinhibitsinnateimmuneresponsebyinitiatinganmir146astat1feedbackloop
AT yuanyuanzhang downregulatedndr1proteinkinaseinhibitsinnateimmuneresponsebyinitiatinganmir146astat1feedbackloop
AT fengma downregulatedndr1proteinkinaseinhibitsinnateimmuneresponsebyinitiatinganmir146astat1feedbackloop
AT jihongsun downregulatedndr1proteinkinaseinhibitsinnateimmuneresponsebyinitiatinganmir146astat1feedbackloop
AT xiaojianwang downregulatedndr1proteinkinaseinhibitsinnateimmuneresponsebyinitiatinganmir146astat1feedbackloop
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