RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

The E3 ligase RNF168 is essential for the signalling of DNA double strand break and its mutations are associated with the RIDDLE syndrome. Here the authors identify TOP2a as substrate for RNF168 and USP10; providing a link between the RNF168/USP10 axis, TOP2a and the response to anti-cancer drugs th...

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Autores principales:	Kiran Kumar Naidu Guturi, Miyuki Bohgaki, Toshiyuki Bohgaki, Tharan Srikumar, Deborah Ng, Ramya Kumareswaran, Samah El Ghamrasni, Justin Jeon, Parasvi Patel, Mohamed Saad Eldin, Rob Bristow, Peter Cheung, Grant S. Stewart, Brian Raught, Anne Hakem, Razqallah Hakem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d5a212c08e97474892af87b85618826a
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spelling	oai:doaj.org-article:d5a212c08e97474892af87b85618826a2021-12-02T17:31:51ZRNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation10.1038/ncomms126382041-1723https://doaj.org/article/d5a212c08e97474892af87b85618826a2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12638https://doaj.org/toc/2041-1723The E3 ligase RNF168 is essential for the signalling of DNA double strand break and its mutations are associated with the RIDDLE syndrome. Here the authors identify TOP2a as substrate for RNF168 and USP10; providing a link between the RNF168/USP10 axis, TOP2a and the response to anti-cancer drugs that target TOP2.Kiran Kumar Naidu GuturiMiyuki BohgakiToshiyuki BohgakiTharan SrikumarDeborah NgRamya KumareswaranSamah El GhamrasniJustin JeonParasvi PatelMohamed Saad EldinRob BristowPeter CheungGrant S. StewartBrian RaughtAnne HakemRazqallah HakemNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kiran Kumar Naidu Guturi Miyuki Bohgaki Toshiyuki Bohgaki Tharan Srikumar Deborah Ng Ramya Kumareswaran Samah El Ghamrasni Justin Jeon Parasvi Patel Mohamed Saad Eldin Rob Bristow Peter Cheung Grant S. Stewart Brian Raught Anne Hakem Razqallah Hakem RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation
description	The E3 ligase RNF168 is essential for the signalling of DNA double strand break and its mutations are associated with the RIDDLE syndrome. Here the authors identify TOP2a as substrate for RNF168 and USP10; providing a link between the RNF168/USP10 axis, TOP2a and the response to anti-cancer drugs that target TOP2.
format	article
author	Kiran Kumar Naidu Guturi Miyuki Bohgaki Toshiyuki Bohgaki Tharan Srikumar Deborah Ng Ramya Kumareswaran Samah El Ghamrasni Justin Jeon Parasvi Patel Mohamed Saad Eldin Rob Bristow Peter Cheung Grant S. Stewart Brian Raught Anne Hakem Razqallah Hakem
author_facet	Kiran Kumar Naidu Guturi Miyuki Bohgaki Toshiyuki Bohgaki Tharan Srikumar Deborah Ng Ramya Kumareswaran Samah El Ghamrasni Justin Jeon Parasvi Patel Mohamed Saad Eldin Rob Bristow Peter Cheung Grant S. Stewart Brian Raught Anne Hakem Razqallah Hakem
author_sort	Kiran Kumar Naidu Guturi
title	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation
title_short	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation
title_full	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation
title_fullStr	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation
title_full_unstemmed	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation
title_sort	rnf168 and usp10 regulate topoisomerase iiα function via opposing effects on its ubiquitylation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d5a212c08e97474892af87b85618826a
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RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

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