Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals utilized in various industrial settings and include products such as flame retardants, artificial film-forming foams, cosmetics, and non-stick cookware, among others. Epidemiological studies suggest a link between increased blood PFA...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ozan Berk Imir, Alanna Zoe Kaminsky, Qian-Ying Zuo, Yu-Jeh Liu, Ratnakar Singh, Michael J. Spinella, Joseph Irudayaraj, Wen-Yang Hu, Gail S. Prins, Zeynep Madak Erdogan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prostate cancer high-fat diet PFAS metabolism Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/d5a3a6ac6a5247f4b3b8824544cdb761
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d5a3a6ac6a5247f4b3b8824544cdb761
record_format	dspace
spelling	oai:doaj.org-article:d5a3a6ac6a5247f4b3b8824544cdb7612021-11-25T18:35:07ZPer- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression10.3390/nu131139022072-6643https://doaj.org/article/d5a3a6ac6a5247f4b3b8824544cdb7612021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3902https://doaj.org/toc/2072-6643Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals utilized in various industrial settings and include products such as flame retardants, artificial film-forming foams, cosmetics, and non-stick cookware, among others. Epidemiological studies suggest a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism through which PFAS impact cancer development is unclear. To investigate the link between PFAS and prostate cancer, we evaluated the impact of metabolic alterations resulting from a high-fat diet combined with PFAS exposure on prostate tumor progression. We evaluated in vivo prostate cancer xenograft models exposed to perfluorooctane sulfonate (PFOS), a type of PFAS compound, and different diets to study the effects of PFAS on prostate cancer progression and metabolic activity. Metabolomics and transcriptomics were used to understand the metabolic landscape shifts upon PFAS exposure. We evaluated metabolic changes in benign or tumor cells that lead to epigenomic reprogramming and altered signaling, which ultimately increase tumorigenic risk and tumor aggressiveness. Our studies are the first in the field to provide new and clinically relevant insights regarding novel metabolic and epigenetic states as well as to support the future development of effective preventative and therapeutic strategies for PFAS-induced prostate cancers. Our findings enhance understanding of how PFAS synergize with high-fat diets to contribute to prostate cancer development and establish an important basis to mitigate PFAS exposure.Ozan Berk ImirAlanna Zoe KaminskyQian-Ying ZuoYu-Jeh LiuRatnakar SinghMichael J. SpinellaJoseph IrudayarajWen-Yang HuGail S. PrinsZeynep Madak ErdoganMDPI AGarticleprostate cancerhigh-fat dietPFASmetabolismNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3902, p 3902 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer high-fat diet PFAS metabolism Nutrition. Foods and food supply TX341-641
spellingShingle	prostate cancer high-fat diet PFAS metabolism Nutrition. Foods and food supply TX341-641 Ozan Berk Imir Alanna Zoe Kaminsky Qian-Ying Zuo Yu-Jeh Liu Ratnakar Singh Michael J. Spinella Joseph Irudayaraj Wen-Yang Hu Gail S. Prins Zeynep Madak Erdogan Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression
description	Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals utilized in various industrial settings and include products such as flame retardants, artificial film-forming foams, cosmetics, and non-stick cookware, among others. Epidemiological studies suggest a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism through which PFAS impact cancer development is unclear. To investigate the link between PFAS and prostate cancer, we evaluated the impact of metabolic alterations resulting from a high-fat diet combined with PFAS exposure on prostate tumor progression. We evaluated in vivo prostate cancer xenograft models exposed to perfluorooctane sulfonate (PFOS), a type of PFAS compound, and different diets to study the effects of PFAS on prostate cancer progression and metabolic activity. Metabolomics and transcriptomics were used to understand the metabolic landscape shifts upon PFAS exposure. We evaluated metabolic changes in benign or tumor cells that lead to epigenomic reprogramming and altered signaling, which ultimately increase tumorigenic risk and tumor aggressiveness. Our studies are the first in the field to provide new and clinically relevant insights regarding novel metabolic and epigenetic states as well as to support the future development of effective preventative and therapeutic strategies for PFAS-induced prostate cancers. Our findings enhance understanding of how PFAS synergize with high-fat diets to contribute to prostate cancer development and establish an important basis to mitigate PFAS exposure.
format	article
author	Ozan Berk Imir Alanna Zoe Kaminsky Qian-Ying Zuo Yu-Jeh Liu Ratnakar Singh Michael J. Spinella Joseph Irudayaraj Wen-Yang Hu Gail S. Prins Zeynep Madak Erdogan
author_facet	Ozan Berk Imir Alanna Zoe Kaminsky Qian-Ying Zuo Yu-Jeh Liu Ratnakar Singh Michael J. Spinella Joseph Irudayaraj Wen-Yang Hu Gail S. Prins Zeynep Madak Erdogan
author_sort	Ozan Berk Imir
title	Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression
title_short	Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression
title_full	Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression
title_fullStr	Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression
title_full_unstemmed	Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression
title_sort	per- and polyfluoroalkyl substance exposure combined with high-fat diet supports prostate cancer progression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d5a3a6ac6a5247f4b3b8824544cdb761
work_keys_str_mv	AT ozanberkimir perandpolyfluoroalkylsubstanceexposurecombinedwithhighfatdietsupportsprostatecancerprogression AT alannazoekaminsky perandpolyfluoroalkylsubstanceexposurecombinedwithhighfatdietsupportsprostatecancerprogression AT qianyingzuo perandpolyfluoroalkylsubstanceexposurecombinedwithhighfatdietsupportsprostatecancerprogression AT yujehliu perandpolyfluoroalkylsubstanceexposurecombinedwithhighfatdietsupportsprostatecancerprogression AT ratnakarsingh perandpolyfluoroalkylsubstanceexposurecombinedwithhighfatdietsupportsprostatecancerprogression AT michaeljspinella perandpolyfluoroalkylsubstanceexposurecombinedwithhighfatdietsupportsprostatecancerprogression AT josephirudayaraj perandpolyfluoroalkylsubstanceexposurecombinedwithhighfatdietsupportsprostatecancerprogression AT wenyanghu perandpolyfluoroalkylsubstanceexposurecombinedwithhighfatdietsupportsprostatecancerprogression AT gailsprins perandpolyfluoroalkylsubstanceexposurecombinedwithhighfatdietsupportsprostatecancerprogression AT zeynepmadakerdogan perandpolyfluoroalkylsubstanceexposurecombinedwithhighfatdietsupportsprostatecancerprogression
_version_	1718410980693639168

Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression

Ejemplares similares