Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is caused by a respiratory virus with a wide range of manifestations, varying from asymptomatic to fatal cases, with a generally short outcome. However, some individuals present long-term viral shedding. We monitored 38 indiv...

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Autores principales:	Marielton dos Passos Cunha, Ana Paula Pessoa Vilela, Camila Vieira Molina, Stephanie Maia Acuña, Sandra Marcia Muxel, Vinícius de Morais Barroso, Sabrina Baroni, Lilian Gomes de Oliveira, Yan de Souza Angelo, Jean Pierre Schatzmann Peron, Luiz Gustavo Bentim Góes, Angélica Cristine de Almeida Campos, Paola Minóprio
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	SARS-CoV-2 prolonged RNA viral shedding immune response coronavirus intra-host evolution Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d5ae3daca7f64103b8a2fe631a803309
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spelling	oai:doaj.org-article:d5ae3daca7f64103b8a2fe631a8033092021-12-01T06:25:19ZAtypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient2296-858X10.3389/fmed.2021.760170https://doaj.org/article/d5ae3daca7f64103b8a2fe631a8033092021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.760170/fullhttps://doaj.org/toc/2296-858XThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is caused by a respiratory virus with a wide range of manifestations, varying from asymptomatic to fatal cases, with a generally short outcome. However, some individuals present long-term viral shedding. We monitored 38 individuals who were mildly affected by the SARS-CoV-2 infection. Out of the total studied population, three (7.9%) showed atypical events regarding the duration of positivity for viral RNA detection. In one of these atypical cases, a previously HIV-positive male patient presented a SARS-CoV-2 RNA shedding and subgenomic RNA (sgRNA) detected from the upper respiratory tract, respectively, for 232 and 224 days after the onset of the symptoms. The SARS-CoV-2 B.1.1.28 lineage, one of the most prevalent in Brazil in 2020, was identified in this patient in three serial samples. Interestingly, the genomic analyses performed throughout the infectious process showed an increase in the genetic diversity of the B.1.1.28 lineage within the host itself, with viral clearance occurring naturally, without any intervention measures to control the infection. Contrasting widely spread current knowledge, our results indicate that potentially infectious SARS-CoV-2 virus might be shed by much longer periods by some infected patients. This data call attention to better adapted non-pharmacological measures and clinical discharge of patients aiming at preventing the spread of SARS-CoV-2 to the population.Marielton dos Passos CunhaAna Paula Pessoa VilelaCamila Vieira MolinaStephanie Maia AcuñaSandra Marcia MuxelSandra Marcia MuxelVinícius de Morais BarrosoVinícius de Morais BarrosoSabrina BaroniLilian Gomes de OliveiraYan de Souza AngeloJean Pierre Schatzmann PeronJean Pierre Schatzmann PeronLuiz Gustavo Bentim GóesLuiz Gustavo Bentim GóesAngélica Cristine de Almeida CamposPaola MinóprioPaola MinóprioFrontiers Media S.A.articleSARS-CoV-2prolonged RNA viral sheddingimmune responsecoronavirusintra-host evolutionMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 prolonged RNA viral shedding immune response coronavirus intra-host evolution Medicine (General) R5-920
spellingShingle	SARS-CoV-2 prolonged RNA viral shedding immune response coronavirus intra-host evolution Medicine (General) R5-920 Marielton dos Passos Cunha Ana Paula Pessoa Vilela Camila Vieira Molina Stephanie Maia Acuña Sandra Marcia Muxel Sandra Marcia Muxel Vinícius de Morais Barroso Vinícius de Morais Barroso Sabrina Baroni Lilian Gomes de Oliveira Yan de Souza Angelo Jean Pierre Schatzmann Peron Jean Pierre Schatzmann Peron Luiz Gustavo Bentim Góes Luiz Gustavo Bentim Góes Angélica Cristine de Almeida Campos Paola Minóprio Paola Minóprio Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient
description	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is caused by a respiratory virus with a wide range of manifestations, varying from asymptomatic to fatal cases, with a generally short outcome. However, some individuals present long-term viral shedding. We monitored 38 individuals who were mildly affected by the SARS-CoV-2 infection. Out of the total studied population, three (7.9%) showed atypical events regarding the duration of positivity for viral RNA detection. In one of these atypical cases, a previously HIV-positive male patient presented a SARS-CoV-2 RNA shedding and subgenomic RNA (sgRNA) detected from the upper respiratory tract, respectively, for 232 and 224 days after the onset of the symptoms. The SARS-CoV-2 B.1.1.28 lineage, one of the most prevalent in Brazil in 2020, was identified in this patient in three serial samples. Interestingly, the genomic analyses performed throughout the infectious process showed an increase in the genetic diversity of the B.1.1.28 lineage within the host itself, with viral clearance occurring naturally, without any intervention measures to control the infection. Contrasting widely spread current knowledge, our results indicate that potentially infectious SARS-CoV-2 virus might be shed by much longer periods by some infected patients. This data call attention to better adapted non-pharmacological measures and clinical discharge of patients aiming at preventing the spread of SARS-CoV-2 to the population.
format	article
author	Marielton dos Passos Cunha Ana Paula Pessoa Vilela Camila Vieira Molina Stephanie Maia Acuña Sandra Marcia Muxel Sandra Marcia Muxel Vinícius de Morais Barroso Vinícius de Morais Barroso Sabrina Baroni Lilian Gomes de Oliveira Yan de Souza Angelo Jean Pierre Schatzmann Peron Jean Pierre Schatzmann Peron Luiz Gustavo Bentim Góes Luiz Gustavo Bentim Góes Angélica Cristine de Almeida Campos Paola Minóprio Paola Minóprio
author_facet	Marielton dos Passos Cunha Ana Paula Pessoa Vilela Camila Vieira Molina Stephanie Maia Acuña Sandra Marcia Muxel Sandra Marcia Muxel Vinícius de Morais Barroso Vinícius de Morais Barroso Sabrina Baroni Lilian Gomes de Oliveira Yan de Souza Angelo Jean Pierre Schatzmann Peron Jean Pierre Schatzmann Peron Luiz Gustavo Bentim Góes Luiz Gustavo Bentim Góes Angélica Cristine de Almeida Campos Paola Minóprio Paola Minóprio
author_sort	Marielton dos Passos Cunha
title	Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient
title_short	Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient
title_full	Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient
title_fullStr	Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient
title_full_unstemmed	Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient
title_sort	atypical prolonged viral shedding with intra-host sars-cov-2 evolution in a mildly affected symptomatic patient
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d5ae3daca7f64103b8a2fe631a803309
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Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient

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