Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice

How boundary regions form in the epithelia of tissues, for example, the squamous–columnar junction is unclear. Here, the authors identify the transcription factors Sox2 and Gata4 as specifying the transitional epithelium in the murine squamous–columnar junction region in the stomach epithelia.

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Main Authors:	Nao Sankoda, Wataru Tanabe, Akito Tanaka, Hirofumi Shibata, Knut Woltjen, Tsutomu Chiba, Hironori Haga, Yoshiharu Sakai, Masaki Mandai, Takuya Yamamoto, Yasuhiro Yamada, Shinji Uemoto, Yoshiya Kawaguchi
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/d5b4d6d2648f4fb79f5c508bf941f035
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spelling	oai:doaj.org-article:d5b4d6d2648f4fb79f5c508bf941f0352021-12-02T13:57:53ZEpithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice10.1038/s41467-021-20906-02041-1723https://doaj.org/article/d5b4d6d2648f4fb79f5c508bf941f0352021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20906-0https://doaj.org/toc/2041-1723How boundary regions form in the epithelia of tissues, for example, the squamous–columnar junction is unclear. Here, the authors identify the transcription factors Sox2 and Gata4 as specifying the transitional epithelium in the murine squamous–columnar junction region in the stomach epithelia.Nao SankodaWataru TanabeAkito TanakaHirofumi ShibataKnut WoltjenTsutomu ChibaHironori HagaYoshiharu SakaiMasaki MandaiTakuya YamamotoYasuhiro YamadaShinji UemotoYoshiya KawaguchiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nao Sankoda Wataru Tanabe Akito Tanaka Hirofumi Shibata Knut Woltjen Tsutomu Chiba Hironori Haga Yoshiharu Sakai Masaki Mandai Takuya Yamamoto Yasuhiro Yamada Shinji Uemoto Yoshiya Kawaguchi Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
description	How boundary regions form in the epithelia of tissues, for example, the squamous–columnar junction is unclear. Here, the authors identify the transcription factors Sox2 and Gata4 as specifying the transitional epithelium in the murine squamous–columnar junction region in the stomach epithelia.
format	article
author	Nao Sankoda Wataru Tanabe Akito Tanaka Hirofumi Shibata Knut Woltjen Tsutomu Chiba Hironori Haga Yoshiharu Sakai Masaki Mandai Takuya Yamamoto Yasuhiro Yamada Shinji Uemoto Yoshiya Kawaguchi
author_facet	Nao Sankoda Wataru Tanabe Akito Tanaka Hirofumi Shibata Knut Woltjen Tsutomu Chiba Hironori Haga Yoshiharu Sakai Masaki Mandai Takuya Yamamoto Yasuhiro Yamada Shinji Uemoto Yoshiya Kawaguchi
author_sort	Nao Sankoda
title	Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
title_short	Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
title_full	Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
title_fullStr	Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
title_full_unstemmed	Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
title_sort	epithelial expression of gata4 and sox2 regulates specification of the squamous–columnar junction via mapk/erk signaling in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d5b4d6d2648f4fb79f5c508bf941f035
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Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice

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