Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice

How boundary regions form in the epithelia of tissues, for example, the squamous–columnar junction is unclear. Here, the authors identify the transcription factors Sox2 and Gata4 as specifying the transitional epithelium in the murine squamous–columnar junction region in the stomach epithelia.

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Autores principales: Nao Sankoda, Wataru Tanabe, Akito Tanaka, Hirofumi Shibata, Knut Woltjen, Tsutomu Chiba, Hironori Haga, Yoshiharu Sakai, Masaki Mandai, Takuya Yamamoto, Yasuhiro Yamada, Shinji Uemoto, Yoshiya Kawaguchi
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d5b4d6d2648f4fb79f5c508bf941f035
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spelling oai:doaj.org-article:d5b4d6d2648f4fb79f5c508bf941f0352021-12-02T13:57:53ZEpithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice10.1038/s41467-021-20906-02041-1723https://doaj.org/article/d5b4d6d2648f4fb79f5c508bf941f0352021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20906-0https://doaj.org/toc/2041-1723How boundary regions form in the epithelia of tissues, for example, the squamous–columnar junction is unclear. Here, the authors identify the transcription factors Sox2 and Gata4 as specifying the transitional epithelium in the murine squamous–columnar junction region in the stomach epithelia.Nao SankodaWataru TanabeAkito TanakaHirofumi ShibataKnut WoltjenTsutomu ChibaHironori HagaYoshiharu SakaiMasaki MandaiTakuya YamamotoYasuhiro YamadaShinji UemotoYoshiya KawaguchiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nao Sankoda
Wataru Tanabe
Akito Tanaka
Hirofumi Shibata
Knut Woltjen
Tsutomu Chiba
Hironori Haga
Yoshiharu Sakai
Masaki Mandai
Takuya Yamamoto
Yasuhiro Yamada
Shinji Uemoto
Yoshiya Kawaguchi
Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
description How boundary regions form in the epithelia of tissues, for example, the squamous–columnar junction is unclear. Here, the authors identify the transcription factors Sox2 and Gata4 as specifying the transitional epithelium in the murine squamous–columnar junction region in the stomach epithelia.
format article
author Nao Sankoda
Wataru Tanabe
Akito Tanaka
Hirofumi Shibata
Knut Woltjen
Tsutomu Chiba
Hironori Haga
Yoshiharu Sakai
Masaki Mandai
Takuya Yamamoto
Yasuhiro Yamada
Shinji Uemoto
Yoshiya Kawaguchi
author_facet Nao Sankoda
Wataru Tanabe
Akito Tanaka
Hirofumi Shibata
Knut Woltjen
Tsutomu Chiba
Hironori Haga
Yoshiharu Sakai
Masaki Mandai
Takuya Yamamoto
Yasuhiro Yamada
Shinji Uemoto
Yoshiya Kawaguchi
author_sort Nao Sankoda
title Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
title_short Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
title_full Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
title_fullStr Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
title_full_unstemmed Epithelial expression of Gata4 and Sox2 regulates specification of the squamous–columnar junction via MAPK/ERK signaling in mice
title_sort epithelial expression of gata4 and sox2 regulates specification of the squamous–columnar junction via mapk/erk signaling in mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d5b4d6d2648f4fb79f5c508bf941f035
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