Diabetes mellitus and the risk of multidrug resistant tuberculosis: a meta-analysis
Abstract The high prevalence of diabetes mellitus (DM) among multidrug resistant tuberculosis (MDR-TB) patients is a serious cause for concern. We conducted a meta-analysis to determine whether DM is an independent risk factor for MDR-TB. Electronic literature searches of the PubMed, Web of Science...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d5bae6ecf94b4573b0380787e7763daa |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d5bae6ecf94b4573b0380787e7763daa |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d5bae6ecf94b4573b0380787e7763daa2021-12-02T16:06:22ZDiabetes mellitus and the risk of multidrug resistant tuberculosis: a meta-analysis10.1038/s41598-017-01213-52045-2322https://doaj.org/article/d5bae6ecf94b4573b0380787e7763daa2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01213-5https://doaj.org/toc/2045-2322Abstract The high prevalence of diabetes mellitus (DM) among multidrug resistant tuberculosis (MDR-TB) patients is a serious cause for concern. We conducted a meta-analysis to determine whether DM is an independent risk factor for MDR-TB. Electronic literature searches of the PubMed, Web of Science and EMBASE databases up to July 12, 2016 were conducted. The pooled adjusted odds ratio (OR) and 95% confidence intervals (CIs) were calculated using the random effects model with STATA 12.0 software. In total 13 studies, including 9289 individuals with TB, were included in this meta-analysis. Significant association between DM and MDR-TB (OR = 1.71; 95% CI = 1.32, 2.22) was identified. Subgroup analyses showed that: 1) Pooled OR was 1.25 (95% CI: 0.82–1.91) for cross-sectional studies, and was 2.14 (95% CI: 1.51–3.02) for longitudinal studies; 2) The pooled OR was 1.69 (95% CI:1.09–2.62) for primary MDR-TB, 1.94 (95% CI:1.42–2.65) for any MDR-TB, and 0.85 for secondary MDR-TB (95% CI: 0.29–2.54); 3) DM was significantly associated with MDR-TB in both Caucasian (OR = 2.26, 95% CI: 1.66–3.07) and Asian (OR = 1.40, 95% CI: 1.01–1.95) subgroups. No evidence of publication bias was identified. In conclusion, the pooling analysis indicated that DM was an independent risk factor for MDR-TB, especially for primary MDR-TB.Qianqian LiuWenzhang LiMiao XueYunfeng ChenXinmiao DuChengdi WangLina HanYin TangYulin FengChuanmin TaoJian-Qing HeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Qianqian Liu Wenzhang Li Miao Xue Yunfeng Chen Xinmiao Du Chengdi Wang Lina Han Yin Tang Yulin Feng Chuanmin Tao Jian-Qing He Diabetes mellitus and the risk of multidrug resistant tuberculosis: a meta-analysis |
| description |
Abstract The high prevalence of diabetes mellitus (DM) among multidrug resistant tuberculosis (MDR-TB) patients is a serious cause for concern. We conducted a meta-analysis to determine whether DM is an independent risk factor for MDR-TB. Electronic literature searches of the PubMed, Web of Science and EMBASE databases up to July 12, 2016 were conducted. The pooled adjusted odds ratio (OR) and 95% confidence intervals (CIs) were calculated using the random effects model with STATA 12.0 software. In total 13 studies, including 9289 individuals with TB, were included in this meta-analysis. Significant association between DM and MDR-TB (OR = 1.71; 95% CI = 1.32, 2.22) was identified. Subgroup analyses showed that: 1) Pooled OR was 1.25 (95% CI: 0.82–1.91) for cross-sectional studies, and was 2.14 (95% CI: 1.51–3.02) for longitudinal studies; 2) The pooled OR was 1.69 (95% CI:1.09–2.62) for primary MDR-TB, 1.94 (95% CI:1.42–2.65) for any MDR-TB, and 0.85 for secondary MDR-TB (95% CI: 0.29–2.54); 3) DM was significantly associated with MDR-TB in both Caucasian (OR = 2.26, 95% CI: 1.66–3.07) and Asian (OR = 1.40, 95% CI: 1.01–1.95) subgroups. No evidence of publication bias was identified. In conclusion, the pooling analysis indicated that DM was an independent risk factor for MDR-TB, especially for primary MDR-TB. |
| format |
article |
| author |
Qianqian Liu Wenzhang Li Miao Xue Yunfeng Chen Xinmiao Du Chengdi Wang Lina Han Yin Tang Yulin Feng Chuanmin Tao Jian-Qing He |
| author_facet |
Qianqian Liu Wenzhang Li Miao Xue Yunfeng Chen Xinmiao Du Chengdi Wang Lina Han Yin Tang Yulin Feng Chuanmin Tao Jian-Qing He |
| author_sort |
Qianqian Liu |
| title |
Diabetes mellitus and the risk of multidrug resistant tuberculosis: a meta-analysis |
| title_short |
Diabetes mellitus and the risk of multidrug resistant tuberculosis: a meta-analysis |
| title_full |
Diabetes mellitus and the risk of multidrug resistant tuberculosis: a meta-analysis |
| title_fullStr |
Diabetes mellitus and the risk of multidrug resistant tuberculosis: a meta-analysis |
| title_full_unstemmed |
Diabetes mellitus and the risk of multidrug resistant tuberculosis: a meta-analysis |
| title_sort |
diabetes mellitus and the risk of multidrug resistant tuberculosis: a meta-analysis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/d5bae6ecf94b4573b0380787e7763daa |
| work_keys_str_mv |
AT qianqianliu diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis AT wenzhangli diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis AT miaoxue diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis AT yunfengchen diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis AT xinmiaodu diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis AT chengdiwang diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis AT linahan diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis AT yintang diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis AT yulinfeng diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis AT chuanmintao diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis AT jianqinghe diabetesmellitusandtheriskofmultidrugresistanttuberculosisametaanalysis |
| _version_ |
1718385057310179328 |