Sensitive detection of a bacterial pathogen using allosteric probe-initiated catalysis and CRISPR-Cas13a amplification reaction

The detection of pathogens in food and clinical samples remains a challenge. Here, Shen et al. present a detection system, involving a combination of nucleic acid-based allosteric probes and CRISPR-Cas13a components, that can detect very low numbers of a bacterial pathogen in milk and serum samples...

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Bibliographic Details
Main Authors: Jinjin Shen, Xiaoming Zhou, Yuanyue Shan, Huahua Yue, Ru Huang, Jiaming Hu, Da Xing
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/d5be5932d63d44d082e55efb605ab928
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