In situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation

Zheng Wang,1 Yan Sun,1 Dongzhou Wang,2 Hong Liu,2 Robert I Boughton31Department of Cardiology, Heilongjiang Provincial Hospital, Haerbin, Heilongjiang, People’s Republic of China; 2State Key Laboratory of Crystal Materials, Shandong University, Jinan, People’s Republic of China;...

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Autores principales:	Wang Z, Sun Y, Wang DZ, Liu H, Boughton RI
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d5bea14a3123466da939581e88a2d7e6
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spelling	oai:doaj.org-article:d5bea14a3123466da939581e88a2d7e62021-12-02T06:46:36ZIn situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation1176-91141178-2013https://doaj.org/article/d5bea14a3123466da939581e88a2d7e62013-08-01T00:00:00Zhttp://www.dovepress.com/in-situ-fabrication-of-silver-nanoparticle-filled-hydrogen-titanate-na-a13934https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Zheng Wang,1 Yan Sun,1 Dongzhou Wang,2 Hong Liu,2 Robert I Boughton31Department of Cardiology, Heilongjiang Provincial Hospital, Haerbin, Heilongjiang, People’s Republic of China; 2State Key Laboratory of Crystal Materials, Shandong University, Jinan, People’s Republic of China; 3Department of Physics and Astronomy, Bowling Green State University, Bowling Green, OH, USAAbstract: A silver nanoparticle (AgNP)-filled hydrogen titanate nanotube layer was synthesized in situ on a metallic titanium substrate. In the synthesis approach, a layer of sodium titanate nanotubes is first prepared on the titanium surface by using a hydrothermal method. Silver nitrate solution is absorbed into the nanotube channels by immersing a dried nanotube layer in silver nitrate solution. Finally, silver ions are reduced by glucose, leading to the in situ growth of AgNPs in the hydrogen titanate nanotube channels. Long-term silver release and bactericidal experiments demonstrated that the effective silver release and effective antibacterial period of the titanium foil with a AgNP-filled hydrogen titanate nanotube layer on the surface can extend to more than 15 days. This steady and prolonged release characteristic is helpful to promote a long-lasting antibacterial capability for the prevention of severe infection after surgery. A series of antimicrobial and biocompatible tests have shown that the sandwich nanostructure with a low level of silver loading exhibits a bacteriostatic rate as high as 99.99%, while retaining low toxicity for cells and possessing high osteogenic potential. Titanium foil with a AgNP-filled hydrogen titanate nanotube layer on the surface that is fabricated with low-cost surface modification methods is a promising implantable material that will find applications in artificial bones, joints, and dental implants.Keywords: titanium implant, silver nanoparticle filling, ion substitution, bacteriostasis, cytocompatibilityWang ZSun YWang DZLiu HBoughton RIDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 2903-2916 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wang Z Sun Y Wang DZ Liu H Boughton RI In situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation
description	Zheng Wang,1 Yan Sun,1 Dongzhou Wang,2 Hong Liu,2 Robert I Boughton31Department of Cardiology, Heilongjiang Provincial Hospital, Haerbin, Heilongjiang, People’s Republic of China; 2State Key Laboratory of Crystal Materials, Shandong University, Jinan, People’s Republic of China; 3Department of Physics and Astronomy, Bowling Green State University, Bowling Green, OH, USAAbstract: A silver nanoparticle (AgNP)-filled hydrogen titanate nanotube layer was synthesized in situ on a metallic titanium substrate. In the synthesis approach, a layer of sodium titanate nanotubes is first prepared on the titanium surface by using a hydrothermal method. Silver nitrate solution is absorbed into the nanotube channels by immersing a dried nanotube layer in silver nitrate solution. Finally, silver ions are reduced by glucose, leading to the in situ growth of AgNPs in the hydrogen titanate nanotube channels. Long-term silver release and bactericidal experiments demonstrated that the effective silver release and effective antibacterial period of the titanium foil with a AgNP-filled hydrogen titanate nanotube layer on the surface can extend to more than 15 days. This steady and prolonged release characteristic is helpful to promote a long-lasting antibacterial capability for the prevention of severe infection after surgery. A series of antimicrobial and biocompatible tests have shown that the sandwich nanostructure with a low level of silver loading exhibits a bacteriostatic rate as high as 99.99%, while retaining low toxicity for cells and possessing high osteogenic potential. Titanium foil with a AgNP-filled hydrogen titanate nanotube layer on the surface that is fabricated with low-cost surface modification methods is a promising implantable material that will find applications in artificial bones, joints, and dental implants.Keywords: titanium implant, silver nanoparticle filling, ion substitution, bacteriostasis, cytocompatibility
format	article
author	Wang Z Sun Y Wang DZ Liu H Boughton RI
author_facet	Wang Z Sun Y Wang DZ Liu H Boughton RI
author_sort	Wang Z
title	In situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation
title_short	In situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation
title_full	In situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation
title_fullStr	In situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation
title_full_unstemmed	In situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation
title_sort	in situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/d5bea14a3123466da939581e88a2d7e6
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In situ fabrication of silver nanoparticle-filled hydrogen titanate nanotube layer on metallic titanium surface for bacteriostatic and biocompatible implantation

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