Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors

The prevalence of diabetes is growing at an alarming rate with increased disability, morbidity, and often premature mortality because of the various complications of this disorder. Chronic hyperglycemia, dyslipidemia, and other metabolic alterations lead to the development and progression of macro-...

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Autores principales:	Elham Hasheminasabgorji, Jay C. Jha
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes atherosclerosis dyslipidemia inflammation redox sensitive factors Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d5bf0b39bcbc43c7979cd8078e26cf61
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id	oai:doaj.org-article:d5bf0b39bcbc43c7979cd8078e26cf61
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spelling	oai:doaj.org-article:d5bf0b39bcbc43c7979cd8078e26cf612021-11-25T16:49:30ZDyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors10.3390/biomedicines91116022227-9059https://doaj.org/article/d5bf0b39bcbc43c7979cd8078e26cf612021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1602https://doaj.org/toc/2227-9059The prevalence of diabetes is growing at an alarming rate with increased disability, morbidity, and often premature mortality because of the various complications of this disorder. Chronic hyperglycemia, dyslipidemia, and other metabolic alterations lead to the development and progression of macro- and microvascular complications of diabetes including cardiovascular, retinal and kidney disease. Despite advances in glucose and lipid lowering treatments, a large number of diabetic individuals develop one or more types of these complications, ultimately leading to end-organ damage over the time. Atherosclerosis is the major macro-vascular complications of diabetes and the primary underlying cause of cardiovascular disease (CVD) posing heavy burden on the health care system. In this review, we discuss the involvement of dyslipidemia in the progression of atherosclerosis by activating the pro-inflammatory cytokines and oxidative stress-related factors. In addition, we also provide information on various pharmacological agents that provides protection against diabetic atherosclerosis by reducing inflammation and oxidative stress.Elham HasheminasabgorjiJay C. JhaMDPI AGarticlediabetesatherosclerosisdyslipidemiainflammationredox sensitive factorsBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1602, p 1602 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes atherosclerosis dyslipidemia inflammation redox sensitive factors Biology (General) QH301-705.5
spellingShingle	diabetes atherosclerosis dyslipidemia inflammation redox sensitive factors Biology (General) QH301-705.5 Elham Hasheminasabgorji Jay C. Jha Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors
description	The prevalence of diabetes is growing at an alarming rate with increased disability, morbidity, and often premature mortality because of the various complications of this disorder. Chronic hyperglycemia, dyslipidemia, and other metabolic alterations lead to the development and progression of macro- and microvascular complications of diabetes including cardiovascular, retinal and kidney disease. Despite advances in glucose and lipid lowering treatments, a large number of diabetic individuals develop one or more types of these complications, ultimately leading to end-organ damage over the time. Atherosclerosis is the major macro-vascular complications of diabetes and the primary underlying cause of cardiovascular disease (CVD) posing heavy burden on the health care system. In this review, we discuss the involvement of dyslipidemia in the progression of atherosclerosis by activating the pro-inflammatory cytokines and oxidative stress-related factors. In addition, we also provide information on various pharmacological agents that provides protection against diabetic atherosclerosis by reducing inflammation and oxidative stress.
format	article
author	Elham Hasheminasabgorji Jay C. Jha
author_facet	Elham Hasheminasabgorji Jay C. Jha
author_sort	Elham Hasheminasabgorji
title	Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors
title_short	Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors
title_full	Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors
title_fullStr	Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors
title_full_unstemmed	Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors
title_sort	dyslipidemia, diabetes and atherosclerosis: role of inflammation and ros-redox-sensitive factors
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d5bf0b39bcbc43c7979cd8078e26cf61
work_keys_str_mv	AT elhamhasheminasabgorji dyslipidemiadiabetesandatherosclerosisroleofinflammationandrosredoxsensitivefactors AT jaycjha dyslipidemiadiabetesandatherosclerosisroleofinflammationandrosredoxsensitivefactors
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Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and ROS-Redox-Sensitive Factors

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