Escaping ESKAPE: A chalcone perspective

High burden of antimicrobial resistance among critical priority pathogens is a major challenge facing humankind. In particular, ESKAPE pathogens - which includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp....

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Autores principales:	Ashwini Uchil, Thokur Sreepathy Murali, Roopa Nayak
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Antibacterial Antibiofilm Antibiotic resistance Chalcone ESKAPE pathogens Hybrid chalcones Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d5c38f689038439b9cc427f63a099636
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spelling	oai:doaj.org-article:d5c38f689038439b9cc427f63a0996362021-11-12T04:32:08ZEscaping ESKAPE: A chalcone perspective2211-715610.1016/j.rechem.2021.100229https://doaj.org/article/d5c38f689038439b9cc427f63a0996362021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221171562100134Xhttps://doaj.org/toc/2211-7156High burden of antimicrobial resistance among critical priority pathogens is a major challenge facing humankind. In particular, ESKAPE pathogens - which includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. - have received wide attention due to their immense clinical importance. Several studies indicate that the biofilm mediated infections associated with these bacteria serve to increase their resistance towards antibiotics, necessitating the urgent need to develop more efficacious and safer drugs. Naturally occurring chalcones, which are precursors of flavonoids, have received wider attention for their potent antibacterial and antibiofilm activity. The ease of synthesis of diverse array of chalcones make them ideal candidates in drug screening programs while chalcone-based derivates and hybrids have been shown to have improved bioactivity, potency and functionality. Future prospects include designing novel chalcones using methods such as bioisosterism as well as developing large-scale screening methods to screen natural and synthetic chalcone libraries for potent antibiofilm activity against ESKAPE pathogens.Ashwini UchilThokur Sreepathy MuraliRoopa NayakElsevierarticleAntibacterialAntibiofilmAntibiotic resistanceChalconeESKAPE pathogensHybrid chalconesChemistryQD1-999ENResults in Chemistry, Vol 3, Iss , Pp 100229- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antibacterial Antibiofilm Antibiotic resistance Chalcone ESKAPE pathogens Hybrid chalcones Chemistry QD1-999
spellingShingle	Antibacterial Antibiofilm Antibiotic resistance Chalcone ESKAPE pathogens Hybrid chalcones Chemistry QD1-999 Ashwini Uchil Thokur Sreepathy Murali Roopa Nayak Escaping ESKAPE: A chalcone perspective
description	High burden of antimicrobial resistance among critical priority pathogens is a major challenge facing humankind. In particular, ESKAPE pathogens - which includes Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. - have received wide attention due to their immense clinical importance. Several studies indicate that the biofilm mediated infections associated with these bacteria serve to increase their resistance towards antibiotics, necessitating the urgent need to develop more efficacious and safer drugs. Naturally occurring chalcones, which are precursors of flavonoids, have received wider attention for their potent antibacterial and antibiofilm activity. The ease of synthesis of diverse array of chalcones make them ideal candidates in drug screening programs while chalcone-based derivates and hybrids have been shown to have improved bioactivity, potency and functionality. Future prospects include designing novel chalcones using methods such as bioisosterism as well as developing large-scale screening methods to screen natural and synthetic chalcone libraries for potent antibiofilm activity against ESKAPE pathogens.
format	article
author	Ashwini Uchil Thokur Sreepathy Murali Roopa Nayak
author_facet	Ashwini Uchil Thokur Sreepathy Murali Roopa Nayak
author_sort	Ashwini Uchil
title	Escaping ESKAPE: A chalcone perspective
title_short	Escaping ESKAPE: A chalcone perspective
title_full	Escaping ESKAPE: A chalcone perspective
title_fullStr	Escaping ESKAPE: A chalcone perspective
title_full_unstemmed	Escaping ESKAPE: A chalcone perspective
title_sort	escaping eskape: a chalcone perspective
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d5c38f689038439b9cc427f63a099636
work_keys_str_mv	AT ashwiniuchil escapingeskapeachalconeperspective AT thokursreepathymurali escapingeskapeachalconeperspective AT roopanayak escapingeskapeachalconeperspective
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Escaping ESKAPE: A chalcone perspective

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