Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20

Abstract Human cytomegalovirus (HCMV) is a major human pathogen, causing serious diseases in immunocompromised populations and congenially infected neonates. One of the main immune cells acting against the virus are Natural Killer (NK) cells. Killing by NK cells is mediated by a small family of acti...

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Autores principales:	Yoav Charpak-Amikam, Tobias Kubsch, Einat Seidel, Esther Oiknine-Djian, Noemi Cavaletto, Rachel Yamin, Dominik Schmiedel, Dana Wolf, Giorgio Gribaudo, Martin Messerle, Luka Cicin-Sain, Ofer Mandelboim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d5c3b10de58544a8b38455e4e3f51e6b
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spelling	oai:doaj.org-article:d5c3b10de58544a8b38455e4e3f51e6b2021-12-02T15:06:19ZHuman cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US2010.1038/s41598-017-08866-22045-2322https://doaj.org/article/d5c3b10de58544a8b38455e4e3f51e6b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08866-2https://doaj.org/toc/2045-2322Abstract Human cytomegalovirus (HCMV) is a major human pathogen, causing serious diseases in immunocompromised populations and congenially infected neonates. One of the main immune cells acting against the virus are Natural Killer (NK) cells. Killing by NK cells is mediated by a small family of activating receptors such as NKp30 that interact with the cellular ligand B7-H6. The outcome of B7-H6-NKp30 interaction was, so far, mainly studied with regard to NK recognition and killing of tumors. Here, we demonstrated that the expression of B7-H6 is upregulated following HCMV infection and that HCMV uses two of its genes: US18 and US20, to interfere with B7-H6 surface expression, in a mechanism involving endosomal degradation, in order to evade NK cell recognition.Yoav Charpak-AmikamTobias KubschEinat SeidelEsther Oiknine-DjianNoemi CavalettoRachel YaminDominik SchmiedelDana WolfGiorgio GribaudoMartin MesserleLuka Cicin-SainOfer MandelboimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoav Charpak-Amikam Tobias Kubsch Einat Seidel Esther Oiknine-Djian Noemi Cavaletto Rachel Yamin Dominik Schmiedel Dana Wolf Giorgio Gribaudo Martin Messerle Luka Cicin-Sain Ofer Mandelboim Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
description	Abstract Human cytomegalovirus (HCMV) is a major human pathogen, causing serious diseases in immunocompromised populations and congenially infected neonates. One of the main immune cells acting against the virus are Natural Killer (NK) cells. Killing by NK cells is mediated by a small family of activating receptors such as NKp30 that interact with the cellular ligand B7-H6. The outcome of B7-H6-NKp30 interaction was, so far, mainly studied with regard to NK recognition and killing of tumors. Here, we demonstrated that the expression of B7-H6 is upregulated following HCMV infection and that HCMV uses two of its genes: US18 and US20, to interfere with B7-H6 surface expression, in a mechanism involving endosomal degradation, in order to evade NK cell recognition.
format	article
author	Yoav Charpak-Amikam Tobias Kubsch Einat Seidel Esther Oiknine-Djian Noemi Cavaletto Rachel Yamin Dominik Schmiedel Dana Wolf Giorgio Gribaudo Martin Messerle Luka Cicin-Sain Ofer Mandelboim
author_facet	Yoav Charpak-Amikam Tobias Kubsch Einat Seidel Esther Oiknine-Djian Noemi Cavaletto Rachel Yamin Dominik Schmiedel Dana Wolf Giorgio Gribaudo Martin Messerle Luka Cicin-Sain Ofer Mandelboim
author_sort	Yoav Charpak-Amikam
title	Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title_short	Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title_full	Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title_fullStr	Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title_full_unstemmed	Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20
title_sort	human cytomegalovirus escapes immune recognition by nk cells through the downregulation of b7-h6 by the viral genes us18 and us20
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d5c3b10de58544a8b38455e4e3f51e6b
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Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20

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