Clinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis

Jiaqi Zhang, Yeye Chen, Lei Liu, Mengxin Zhou, Cheng Huang, Chao Guo, Shanqing Li Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of ChinaCorrespondence: Shanqing LiDepartm...

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Autores principales:	Zhang J, Chen Y, Liu L, Zhou M, Huang C, Guo C, Li S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	primary mediastinal malignant germ cell tumors surgery prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d5c5eb0a2648492bb2aa92f11ed43250
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spelling	oai:doaj.org-article:d5c5eb0a2648492bb2aa92f11ed432502021-11-14T19:00:30ZClinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis1179-1322https://doaj.org/article/d5c5eb0a2648492bb2aa92f11ed432502021-11-01T00:00:00Zhttps://www.dovepress.com/clinicopathological-features-and-prognosis-of-primary-mediastinal-mali-peer-reviewed-fulltext-article-CMARhttps://doaj.org/toc/1179-1322Jiaqi Zhang, Yeye Chen, Lei Liu, Mengxin Zhou, Cheng Huang, Chao Guo, Shanqing Li Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of ChinaCorrespondence: Shanqing LiDepartment of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing, 100730, People’s Republic of ChinaTel +86 13801388072Fax +86 1069152632Email lishanqing@pumch.cnBackground: Given the lack of evidence-supported guidance for therapeutic recommendations of primary mediastinal malignant germ cell tumors (PMMGCTs), our study aimed to investigate the clinicopathological features, treatment strategies, and prognostic factors of PMMGCTs.Methods: We carried out a consecutive retrospective evaluation on a series of patients diagnosed with PMMGCTs in Peking Union Medical College Hospital from January 2000 to August 2020.Results: A total of 58 patients were eligible, consisting of 51 males and seven females. There were 15 patients with seminomas, 39 with nonseminomatous germ cell tumors (NSGCTs), and four with mixed germ cell tumors (GCTs). The 5-year overall survival was 45%, with a median survival time of 32.37 months. Except for the lost follow-up of seven patients, a univariate analysis of overall survival on the remaining patients showed significant differences in pathological type (mixed GCTs were regarded as NSGCTs) (p=0.036), tumor size (> 11cm) (p=0.006), and other sites metastases (OSM) (p=0.001), respectively. Multivariate Cox regression analysis revealed that OSM and surgical resection were independently associated with overall survival in all kinds of PMMGCTs.Conclusion: OSM was an independent risk factor for patients with PMMGCTs. Surgery was proved to contribute to long-term survival. More in-depth clinical evidence is urgently needed to guide the treatment of PMMGCTs.Keywords: primary mediastinal malignant germ cell tumors, surgery, prognosisZhang JChen YLiu LZhou MHuang CGuo CLi SDove Medical Pressarticleprimary mediastinal malignant germ cell tumorssurgeryprognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Management and Research, Vol Volume 13, Pp 8527-8534 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	primary mediastinal malignant germ cell tumors surgery prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	primary mediastinal malignant germ cell tumors surgery prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zhang J Chen Y Liu L Zhou M Huang C Guo C Li S Clinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis
description	Jiaqi Zhang, Yeye Chen, Lei Liu, Mengxin Zhou, Cheng Huang, Chao Guo, Shanqing Li Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of ChinaCorrespondence: Shanqing LiDepartment of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing, 100730, People’s Republic of ChinaTel +86 13801388072Fax +86 1069152632Email lishanqing@pumch.cnBackground: Given the lack of evidence-supported guidance for therapeutic recommendations of primary mediastinal malignant germ cell tumors (PMMGCTs), our study aimed to investigate the clinicopathological features, treatment strategies, and prognostic factors of PMMGCTs.Methods: We carried out a consecutive retrospective evaluation on a series of patients diagnosed with PMMGCTs in Peking Union Medical College Hospital from January 2000 to August 2020.Results: A total of 58 patients were eligible, consisting of 51 males and seven females. There were 15 patients with seminomas, 39 with nonseminomatous germ cell tumors (NSGCTs), and four with mixed germ cell tumors (GCTs). The 5-year overall survival was 45%, with a median survival time of 32.37 months. Except for the lost follow-up of seven patients, a univariate analysis of overall survival on the remaining patients showed significant differences in pathological type (mixed GCTs were regarded as NSGCTs) (p=0.036), tumor size (> 11cm) (p=0.006), and other sites metastases (OSM) (p=0.001), respectively. Multivariate Cox regression analysis revealed that OSM and surgical resection were independently associated with overall survival in all kinds of PMMGCTs.Conclusion: OSM was an independent risk factor for patients with PMMGCTs. Surgery was proved to contribute to long-term survival. More in-depth clinical evidence is urgently needed to guide the treatment of PMMGCTs.Keywords: primary mediastinal malignant germ cell tumors, surgery, prognosis
format	article
author	Zhang J Chen Y Liu L Zhou M Huang C Guo C Li S
author_facet	Zhang J Chen Y Liu L Zhou M Huang C Guo C Li S
author_sort	Zhang J
title	Clinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis
title_short	Clinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis
title_full	Clinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis
title_fullStr	Clinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis
title_full_unstemmed	Clinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis
title_sort	clinicopathological features and prognosis of primary mediastinal malignant germ cell tumors: a retrospective single-institution analysis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/d5c5eb0a2648492bb2aa92f11ed43250
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Clinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis

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